The CMMC research areas
The three CMMC research areas enhance and strengthen innovative molecular research with clinical reference
The CMMC fosters interdisciplinary collaboration from the laboratory to the clinic as well as offers an exceptional training ground for the next generation of scientists and clinicians having a strong interest in and firm commitment to biomedical research. The research projects supported by the different funding programs are grouped within three CMMC core research areas:
Research Area A
Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion
- Bazzi, Hisham - A 01
The mitotic surveillance pathway in stem cells - Bergami, Matteo | Motori, Elisa - A 02
Role of synaptic hijacking in SCLC brain metastatic growth - Bozek, Katarzyna - assoc. RG 33
Data Science of Bioimages - Brägelmann, Johannes - CAP 18
Dissecting the molecular mechanisms of tumor evolution and therapy resistance - Büttner, Reinhard | Kondylis, Evangelos - A 03
Systematic mapping of the p62-KEAP1-NRF2 axis and co-regulated pathways across human cancers - Escobar-Henriques, Mafalda - CAP 14
Role of mitofusin 2 in health and disease - Fischer, Matthias - A 04
Elucidating the mechanisms of spontaneous regression and differentiation in neuroblastoma using genetically engineered mouse models - Frenzel, Lukas | Hallek, Michael - A 05
The dialogue of CLL cells with the tumor microenvironment as a mediator of treatment resistance against targeted inhibitor combinations - Grüll, Holger - assoc. RG 41
Experimental Imaging and Image-Guided Therapy - Hillmer, Axel | Büttner, Reinhard - A 06
Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma - Jachimowicz, Ron - assoc. RG 36
- Kath-Schorr, Stephanie - assoc. RG 42
Nucleic Acid Chemistry - von Karstedt, Silvia - A 07
Targeting the Necroptosis Pathway in Pancreatic Cancer - Kurian, Leo - A 08
Engineering mRNA translation specialization modules to ameliorate pathological cardiac hypertrophy: from pathomechanisms to clinical targets, and off-the-shelf therapeutic strategies - Leidecker, Orsolya - CAP 30
Maintenance of Genome Stability and Nuclear Integrity - Motori, Elisa - assoc. JRG 10
Mitochondrial regulation of cellular function - Nguyen, Phuong-Hien | Renata Stripecke | Alessandro Annibaldi - A 09
Understanding the multifaceted regulation of T cell immunity in B cell lymphoma for improved immunotherapy - Nguyen, Phuong-Hien - CAP 19
Deciphering the functional relevance and signal transduction network of protein kinases in the tumor microenvironment - Niemann, Catherin - assoc. RG 14
Stem cell and cancer biology - Notara, Maria - assoc. RG 47
Effects of UV irradiation on corneal angiogenic privilege: pterygium as a UV-induced stem cell disease model: The limbal niche and corneal avascularity - Pallasch, Christian P | Heidenreich, Axel - assoc. RG 15
Exploiting tumor heterogeneity and tumor microenvironment interactions in Testicular Germ Cell Tumors (TGCT) impacting metastasis and therapy response - Peifer, Martin - assoc. RG 16
Computational cancer genomics - Peltzer, Nieves - assoc. RG 46
Cell death and inflammation in health and disease - Pöpsel, Simon - JRG 11
Chromatin Biochemistry - Schumacher, Björn - A 10
Bypassing hotspot mutated p53 - Schweiger, Michal-Ruth assoc. RG 35
Epigenetic mechanisms of cancer development, progression and resistance to therapy - Thomas, Roman - assoc. RG 22
Lung Cancer Genomics - Ullrich, Roland T. - assoc. RG 23
Targeting tumor angiogenesis - Wodarz, Andreas - assoc. RG 24
Molecular control of cell polarity in epithelia and stem cells - Wunderlich, Thomas - A 11
The crosstalk between marginal zone B cells and female hormonal state in the development of benign liver cancer - Grosskopf-Kroiher, Debora | Mauch, Cornelia - PP 1
Cancer Prevention Project: Die Sonne und Wir
Research Area B
Principles of immunity, inflammation and infection
- Annibaldi, Alessandro - JRG 12
Understanding the role of cell death in health and disease - Baldus, Stephan - assoc. RG 01
Inflammatory pathways in ischemia- and chemotherapy-induced heart failure - the role of extracellular vesicles as carriers of leukocyte-derived peroxidases - Bock, Felix - assoc. RG 04
Local Immune Modulation in Experimental Ophthalmology - Brähler, Sebastian - CAP 17
Immunobiology of glomerular diseases - Brinkkötter, Paul | Brähler, Sebastian - B 01
Inflammatory signaling in the PDSS2-model of metabolic podocyte damage – from mouse models to human biopsy analysis - Cabreiro, Filipe | Corrado, Mauro | Solagna, Francesca - B 02
Role of gut microbiota on the onset of sarcopenia - Chmielewski, Markus - assoc. RG 30
High efficient and safe CAR T cells for treatment of tumors - Cornely, Oliver A - assoc. RG 28
Translational research in compromised immunity and immune responses - Corrado, Mauro - CAP 21
Investigating the metabolic determinants of T cell immunological memory - Corrado, Mauro - B 03
Epigenetic-metabolic crosstalk in the development of T cell immunological memory - Cursiefen, Claus | Hadrian, Karina | Hos, Deniz - B 04
Targeting the osmosensitive transcription factor NFAT5 in acute and chronic corneal edema - Hombach, Andreas - assoc. RG 29
Designing smart CAR T cells for improved clinical efficiency - Hoyer, Friedrich F - CAP 22
Myeloid Leukocytes in Cardiovascular and Systemic Inflammation - Ising, Christina - CAP 29
Microglia Cell Death and Senescence in Tauopathies - Jantsch, Jonathan - B 05
Endothelial cells and pericytes in cutaneous leishmaniasis - Kashkar, Hamid - B 06
Role of IAPs in TNF-induced vasculature alteration and their therapeutic value in inflammatory diseases - Klein, Florian - assoc. RG 10
Antibody-mediated therapy and prevention of infectious pathogens - Krönke, Martin - SRG 03
Metabolic Virulence of Staphylococcus aureus - Langmann, Thomas | Wolf, Anne - B 07
Retinal microglia and their immunological effects in AAV-based ocular gene therapy - Liccardi, Gianmaria - assoc. RG 43
- Maier, Berenike | Higgins, Paul - B 08
Correlating biofilm structure with antibiotic tolerance - Neumann-Haefelin, Christoph - assoc. RG 49
- Pasparakis, Manolis - B 09
Role of autophagy in the regulation of ZBP1-mediated cell death and inflammation - Rybniker, Jan | Theobald, Sebastian - B 10
Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination - Schlößer, Hans A - assoc. RG 45 (former CAP 12)
Tumor-specific endogenous immune response and immune escape in gastrointestinal Cancer - Schommers, Philipp - assoc. RG 48
Laboratory of Antiviral Immunity - Simonis, Alexander - assoc. JRG 09 and CAP 27
Translational Immunology in Infectious Diseases - Trifunovic, Aleksandra - B 11
Role of mitochondria in the regulation of innate immunity responses - Winkels, Holger | Mollenhauer, Martin - B 12
Olfr2-mediated macrophage activation in obesity induced endothelial dysfunction - Wolf, Anne - CAP 34
Investigation of the Mechanisms and Triggers leading to a Detrimental Retinal Immune Response during AAV-based Retinal Gene Therapy
Research Area C
Molecular mechanisms and metabolic control of tissue degeneration and regeneration
- Alejandre Alcázar, Miguel A - assoc. RG 38
Deciphering early aberrant morphogenic programming of lung and heart as determinant of risk for disease - Antczak, Philipp - assoc. JRG 06 and CAP 20
Understanding the molecular basis of stress, longevity, and aging - Beck, Bodo | Erger, Florian - assoc. RG 03
Rare and herediatry kidney diseases - Benzing, Thomas - C 01
Pressure-dependent proteostasis regulation in podocytes at the kidney filtration barrier and the pathogenesis of albuminuria - Beyer, Andreas | Hänsel-Hertsch, Robert - C 02
Detecting transcriptional mistakes of RNA Polymerase-II at the single-cell level - Brachvogel, Bent - assoc. RG 50
Mitochondrial dysfunction in skeletal diseases - Brüning, Jens C - C 03
Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity - Clahsen, Thomas - assoc. RG 05
Identification of novel endogenous modulators of developmental and inflammatory lymphangiogenesis by analyzing mouse strain-specific differences - Eming, Sabine | Fabri, Mario - C 04
Unlocking tissue protective and regenerative functions of myeloid cells by metabolic reprograming - Fischer, Dietmar - assoc. RG 44
Validation of a new natural class of compounds for therapeutic use in nerve regeneration - Gehring, Niels - C 05
Function of nonsense-mediated mRNA decay in brain development and neurological disease - Hammerschmidt, Matthias - C 06
Novel pathomechanisms of spine abnormalities and intervertebral disc degeneration caused by mutations in the fatty acid synthase gene - Hänsel-Hertsch, Robert - JRG 10
(Epi)Genome structure and stability - Hoppe, Thorsten - C 07
Understanding the pathomechanism of spinocerebellar ataxia caused by inherited mutations in the ubiquitin ligase CHIP - Isbrandt, Dirk - assoc. RG 39
- Kloppenburg, Peter - assoc. RG 11
Modulation of motivation regulating neurocircuits - Krieg, Thomas - SRG 02
The role of activated fibroblasts in fibrosis – scleroderma as a model disease - Kononenko, Natalia - C 08
Dissecting the role of Alzheimer’s disease-associated endocytosis risk factors in regulating cell cycle events in neuronal cells - Korotkova, Tatiana | Schaefer, Anne - C 09
Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology - Krüger, Marcus - assoc. RG 40
Quantitative Proteomics - Lemberg, Marius | Schiavinato, Alvise | Nüchel, Julian - C 10
Triaging of secretory cargo by interplay of TANGO1 and ERAD-R - Liebau, Max C | Schermer, Bernhard - C 11
Understanding the mechanisms underlying early kidney failure in ARPKD - Maleki, Hajar - assoc. JRG 08 and CAP 35
Functional Bio-inspired Porous Materials - Müller, Roman-Ulrich - assoc. RG 13
Hypoxia-signaling at the crossroads of cellular stress resistance and tumorigenesis - Niessen, Carien M | Hanßen, Ruth - C 12
Skin insulin resistance in type II diabetes and its associated diseases - Nüchel, Julian - CAP 31
- Pfannkuche, Kurt P - assoc. RG 17
Cardiac tissue engineering - Piano, Valentina - CAP 32
Uncovering the mechanisms regulating mitochondrial dynamics during cell division - Rosenkranz, Stephan | Vantler, Marius - C 13
Role of TNF-mediated inflammatory signaling in heart failure with preserved ejection fraction (HFpEF) and associated pulmonary hypertension (PH) - Rugarli, Elena I - C 14
Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways - Schwarz, Günter - C 15
Development of treatments for molybdenum cofactor and sulfite oxidase deficiency - Sengle, Gerhard - assoc. RG 21
New molecular mechanisms of fibrosis - Stoffel, Wilhelm - SRG 01
Antagonistic pleiotropy of the Δ6-fatty acid desaturase (fads2) gene in disease and senescence. ω3- and ω6-Polyunsaturated fatty acids in Δ6-fatty acid desaturase (fads2-/-) deficiency - Trentini Schmidt, Débora B - assoc. JRG 05 and CAP 33
Protein quality control and stress response - Vilchez, David - C 16
Correction of alterations in the ubiquitinated proteome to prevent age-related neurodegenerative diseases - Vogt, Johannes | Kepser, Lara-Jane - C 17
Bioactive lipid signaling in adult neurogenesis and metabolic modulation - Wirth, Brunhilde | Piano, Valentina - C 18
Vesicular trafficking and axonal local translation in health and motor neuron disease - Zempel, Hans - CAP 28
Molecular Mechanisms and Gene Therapy approaches for Genetic and Sporadic Neurodegenerative Diseases
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