The CMMC research areas
The three CMMC research areas enhance and strengthen innovative molecular research with clinical reference
The CMMC fosters interdisciplinary collaboration from the laboratory to the clinic as well as offers an exceptional training ground for the next generation of scientists and clinicians having a strong interest in and firm commitment to biomedical research. The research projects supported by the different funding programs are grouped within three CMMC core research areas:
Research Area A
Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion
- Balke-Want, Hyatt - CAP 36
T cell and Genome Engineering - Fischer, Matthias - A 01
Tracing Determinants of Malignant Transformation in Neuroblastic Tumors on the Single Cell Level - Frezza, Christian | Schatton, Désirée - A 02
Dietary Interventions for Renal Cancer in Hereditary Leiomyomatosis and Renal Cell Carcinoma - Fritsch, Melanie - assoc. RG
Role of Death Receptors in CAR-T cell therapy - Hillmer, Axel | Büttner, Reinhard - A 03
Developing New Treatment Concepts for "KEAP1"-Mutated Lung Adenocarcinoma - Jachimowicz, Ron D. - A 04
Targeting UBQLN1-Driven Oncogenesis in Lung Adenocarcinoma - von Karstedt, Silvia - A 05
Modelling KRAS Inhibitor Resistance Driven by Acquired KRAS Mutations in Pancreatic Cancer - Leidecker, Orsolya - CAP 30
Maintenance of Genome Stability and Nuclear Integrity - Motori, Elisa - assoc. JRG 10
Mitochondrial regulation of cellular function - Motori, Elisa | Kreuzaler, Peter - A 06 (TP)
Neuro-Metabolic Priming in Breast Cancer: Uncovering Innervation-Induced Mechanisms of Brain Metastatic Competence - Nguyen, Phuong-Hien - assoc. RG
Laboratory for Tumor-Host Interdependence - Niemann, Catherin - assoc. RG 14
Stem cell and cancer biology - Notara, Maria - assoc. RG 47
Effects of UV irradiation on corneal angiogenic privilege: pterygium as a UV-induced stem cell disease model: The limbal niche and corneal avascularity - Pöpsel, Simon - assoc. RG
Chromatin Biochemistry - Schweiger, Michal-Ruth assoc. RG 35
Epigenetic mechanisms of cancer development, progression and resistance to therapy - Stangherlin, Alessandra | assoc. RG
Circadian Control of Cellular Homeostasis in Health and Disease - Stripecke, Renata - assoc. RG
Stripecke Lab - Walczak, Henning - A 07
Evaluation of Novel Pro-Apoptotic Combination Therapies to Overcome Therapy Resistance in Haematological Malignancies - Winkels, Holger - assoc. RG
Immune Cell Interactions in Cardiovascular Disease - Grosskopf-Kroiher, Debora | Mauch, Cornelia - PP 1
Cancer Prevention Project: Die Sonne und Wir
Research Area B
Principles of immunity, inflammation and infection
- Annibaldi, Alessandro - JRG 12
Understanding the role of cell death in health and disease - Baldus, Stephan - assoc. RG 01
Inflammatory pathways in ischemia- and chemotherapy-induced heart failure - the role of extracellular vesicles as carriers of leukocyte-derived peroxidases - Brinkkötter, Paul | Brähler, Sebastian - B 01
Plexin Signaling in Podocyte Disease – Linking Inflammation and Actin Cytoskeleton Remodeling - Corrado, Mauro - CAP 21
Investigating the metabolic determinants of T cell immunological memory - Cursiefen, Claus - assoc. RG
Targeting the osmosensitive transcription factor NFAT5 in acute and chronic corneal edema - Ernst, Christoph - assoc. RG
Persistence and evolution of bacterial infections - Hadrian, Karina - assoc. RG
Improving corneal graft survival in a murine aniridia model - Howaldt, Antonia - CAP 38
Innate viral immune response and cell death mechanisms in HSV-1 keratitis - Hoyer, Friedrich F - CAP 22
Myeloid Leukocytes in Cardiovascular and Systemic Inflammation - Ising, Christina - CAP 29
Microglia Cell Death and Senescence in Tauopathies - Jantsch, Jonathan - assoc. RG
- Kashkar, Hamid - B 02
Role of IAPs in Gastrointestinal Inflammatory Diseases and Therapeutic Interventions - Klein, Florian | Rohde, Malena - B 03
HIV-1 Post-Treatment Control by Autologous Neutralizing Antibodies - Krönke, Martin - SRG 03
Metabolic Virulence of Staphylococcus aureus - Liccardi, Gianmaria - B 04
The Role of Necroptosis in the Pathogenesis and Treatment of STING Associated Vasculopathy with Onset in Infancy (SAVI) - Maier, Berenike - assoc. RG
Physics of bacterial systems - Mathur, Sanjay | Hallek, Michael - B 05 (TP)
Stimuli-responsive Nanocarriers for Precision Drug Delivery and Tumor Microenvironment - Neumann-Haefelin, Christoph | Meli-Lang, Julia - B 06
Impact of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) on Immune Control of Chronic Hepatitis B Virus Infection - Pasparakis, Manolis - B 07
Role of Cell Death in Regulating the cGAS-STING-Dependent Interferonopathy Caused by TREX1 Deficiency - Rybniker, Jan | Theobald, Sebastian - B 08
Comparative Analysis of Cross-Protective Trained Innate Immunity Induced by Different Vaccine Platforms - Schlereth, Simona - CAP 40
Therapeutic regulation of innate immune responses in ocular allergy - Schlößer, Hans A - B 09
Elucidating IFN-γ-related Immune Escape as Mechanism of Resistance to Immunotherapy in Human Gastric Cancer and Orthotopic Mouse Models of Genomically Stable and Chromosomally Instable Gastric Adenocarcinoma - Schommers, Philipp - B 10
Engineering Novel Multi-Specific HIV Antibodies to Overcome Viral Resistance - Simonis, Alexander - assoc. JRG 09 and CAP 27
Translational Immunology in Infectious Diseases - Wolf, Anne - CAP 34
Investigation of the Mechanisms and Triggers leading to a Detrimental Retinal Immune Response during AAV-based Retinal Gene Therapy - Zehner, Matthias - CAP 41
Antibody-Based Strategies for Targeting HCMV: From Mechanistic Insights to Therapeutic Applications - Zehner, Matthias - B 11
Investigation of HCMV Resistance and Immune Escape Pathways – HCMV-RISE
Research Area C
Molecular mechanisms and metabolic control of tissue degeneration and regeneration
- Alejandre Alcázar, Miguel - assoc. RG
Deciphering intergenerational aberrant morphogenic programming of lung and heart as determinant of risk for disease across life span - Antczak, Philipp - assoc. JRG 06 and CAP 20
Understanding the molecular basis of stress, longevity, and aging - Beck, Bodo - assoc. RG
Rare and herediatry kidney diseases - Benzing, Thomas | Gather, Malte - C 01 (TP)
Biophysics of Podocyte Machanoregulation and Contractility - Bergami, Matteo - C 02
Mechanisms Underlying Epileptic Phenotypes by the Mitochondrial Transport Adaptor Protein TRAK1 - Brachvogel, Bent - C 03
Reductive Imbalances as Driver of Cartilage Degeneration in Aging and Mitochondrial Disease - Brüning, Jens C - assoc. RG
Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity - Cabreiro, Filipe | Struble, Sebastian | Solagna, Francesca - C 04
Role of the Gut Microbiota in Polycystic Kidney Disease - Eming, Sabine | Reznick, Jane - C 05 (TP)
Investigating Molecular Mechanisms Controlling Regenerative Plasticity and Scar-free Healing in Mammals - Fenech, Emma - CAP 37
Defining specificity of homologous machineries resident in the secretory pathway - Gatto, Graziana - C 06
Unlocking the Prodromal Code: Early Signs of Sensory Dysfunctions in Diabetic Neuropathy - Gehring, Niels - assoc. RG
Post-Transcriptional Gene Regulation by RNA-binding proteins - Hammerschmidt, Matthias - C 07
Analysis of the Molecular Mechanisms Underlying Scar-free Healing of Cutaneous Wounds in the Zebrafish - Hänsel-Hertsch, Robert - JRG 10
(Epi)Genome structure and stability - Hanßen, Ruth - assoc. RG
Translational Metabolism - Isbrandt, Dirk | Tsortouktzidis, Despina - C 08
Precision Therapies for HCN1-DEE - Korotkova, Tatiana - C 09
Neuronal Mechanisms of Hunger Resistance: Functional Roles of Cholecystokinin (CCK)-expressing Lateral Hypothalamic Neurons in Obesity and Anorexia Nervosa - Krieg, Thomas - SRG 02
The role of activated fibroblasts in fibrosis – scleroderma as a model disease - Maleki, Hajar - assoc. JRG 08 and CAP 35
Functional Bio-inspired Porous Materials - Niessen, Carien M - assoc. RG
Skin insulin resistance in type II diabetes and its associated diseases - Nüchel, Julian - CAP 31
- Piano, Valentina - CAP 32
Uncovering the mechanisms regulating mitochondrial dynamics during cell division - Riffelmacher, Thomas - assoc. RG
Metabolic Control of Innate-like T cells - Rosenkranz, Stephan - assoc. RG
Growth factor signaling in cardiovascular diseases - Rugarli, Elena I - C 10
The Role of the Integrated Stress Response and of Paraplegin-specific Substrates in Neurodegeneration Caused by Mutations in SPG7 - Schermer, Bernhard | Ebert, Lena - C 11
Next-Generation Cilia Proximity Labeling to Decipher the Pathomechanisms of Human Ciliopathies - Schwarz, Günter | Köhler, Felix - C 12
MBK2910 to Treat Acute Kidney Injury: From Molecular Mechanism to Clinical Application - Trentini Schmidt, Débora B - assoc. JRG 05 and CAP 33
Protein quality control and stress response - Trifunovic, Aleksandra | Riemer, Jan - C 13 (TP)
Turning Over Complex I: A Redox-Guided Route to Mitochondrial Resilience in Metabolic Disease - Vilchez, David - C 14
Defining Cold-induced Pathways to Prevent Aging and Age-related Diseases - Vogt, Johannes | Kepser, Lara-Jane | Endle, Heiko - C 15
Lipid Signaling in the Regulation of Circuit Integration and Cell Death During Adult Neurogenesis - Wirth, Brunhilde - assoc. RG
Vesicular trafficking and axonal local translation in health and motor neuron disease - Zempel, Hans - CAP 28
Molecular Mechanisms and Gene Therapy approaches for Genetic and Sporadic Neurodegenerative Diseases
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