Center for Molecular Medicine Cologne

Senior Research Groups

The CMMC has provided support since 2008 to outstanding, officially retired senior scientists, who demonstrate a sustained high level of productivity and whose expertise and research accomplishments have been and will continue to be crucial to the CMMC. In line with this, the CMMC awarded Professor Wilhelm Stoffel (Emeritus, Lab. for Molecular Neurobiology) and Professor Thomas Krieg  (Translational Matrix Biology) a SRG Leader position for the current funding period 2020 - 2020.

CMMC SRG I - Antagonistic pleiotropy of the Δ6-fatty acid desaturase (fads2) gene in disease and senescence. ω3- and ω6-Polyunsaturated fatty acids in Δ6-fatty acid desaturase (fads2-/-) deficiency

Wilhelm Stoffel

Laboratory of Molecular Neuroscience | Institute for Biochemistry

We generated an unbiased mammalian model, the fads2-/- mouse, deprived of ω3- and ω6-PUFA synthesis.

The fads2-/- mouse is auxotrophic and an ideal experimental platform for deciphering the molecular basis underlying the role of PUFAs in cell biology, membrane and nutritional research and altered lipid homeostasis in related pathologies.

Fads2 is an antagonistic pleiotropic gene.

CMMC - Project Profile
Link to PubMed
Curriculum Vitae (CV)

CMMC SRG II - The role of activated fibroblasts in fibrosis – scleroderma as a model disease

Thomas Krieg