Aggregation into colonies and biofilms can protect bacteria from antibiotic treatment. Treatment of biofilm-related infections requires a detailed understanding of the molecular mechanisms of antibiotic tolerance. This project aims at understanding how colony formation protects the human pathogen Neisseria gonorrhoeae from antibiotic treatment. We will focus on the interplay between the physical properties of gonococcal colonies and antibiotic susceptibility.
According to WHO, gonorrhea is currently the second most common STI worldwide. Vaccination is not available and the probability of failure of treatment with antibiotics is rising rapidly (1). Due to its rapid acquisition of antibiotic resistance, (multi-) drug resistant N. gonorrhoeae have been termed an urgent threat by the US Center for Disease Control. Some aspects of drug resistance are understood at the genetic level, but the effect of biofilm formation and its properties on efficiency of treatment remains poorly understood. This project aims at elucidating potential mechanisms of antibiotic tolerance in gonococcal biofilms.
Institute for Biological Physics - Center for Molecular Biosciences
CMMC - PI - B 08show more…
Dr. Marc Hennes
Dr. Stephan Wimmi
Dr. Melih Yüksel
Institute for Medical Microbiology, Immunology and Hygiene
CMMC - Co-PI - B 08show more…
Dr. Kyriaki Xanthopoulou
Dr (med) Annika Y. Claßen
Rocío Arazo del Pino