Korotkova, Tatiana | Schaefer, Anne - C 09
Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology
Prof. Dr. Tatiana Korotkova
Institute of Vegetative Physiology
CMMC - PI - C 09
Executive Board Member
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Institute of Vegetative Physiology
Robert-Koch-Str. 39
50931 Cologne
Professorin Dr. Anne Schaefer
Max Planck Institute for Biology of Ageing
CMMC - Co-PI - C 09
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Max Planck Institute for Biology of Ageing
Joseph-Stelzmann-Str. 9b
50931 Cologne
Introduction
The group of Tatiana Korotkova investigates neuronal mechanisms of innate behaviors, including feeding, social interactions and voluntary locomotion, in health and pathology. The overall goal of our group is to unravel functions of hypothalamic neuronal circuits in health and disease. We aim to decode neuronal mechanisms of neuropsychiatric disorders, associated with dysfunctions of hypothalamus, including eating disorders. To reveal and decode influence of various neuronal groups and their inputs on innate behaviors, we combine state-of-the-art technologies including multisite high-density neuronal recordings in transgenic behaving mice, calcium imaging, optogenetics, chemogenetics, subsecond behavioral analysis as well as novel computational and engineering approaches.
For information about Prof. Korotkova's and Prof. Schaefer's research and work, please visit the following pages: Korotkova Lab and Schaefer Lab
Affiliations - Anne Schaefer
Publications generated during 1/2023-12/2025 with CMMC affiliation
2024 (up to June)
- Chen C, Altafi M, Corbu MA, Trenk A, van den Munkhof H, Weineck K, Bender F, Carus-Cadavieco M, Bakhareva A, Korotkova T, and Ponomarenko A (2024). The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions. Nat Neurosci. doi:10.1038/s41593-024-01598-3.
2023
- Knierim E, Vogt J, Kintscher M, Ponomarenko A, Baumgart J, Beed P, Korotkova T, Trimbuch T, Panzer A, Steinlein OK, Stephani U, Escayg A, Koko M, Liu Y, Lerche H, Schmitz D, Nitsch R, and Schuelke M (2023). Mutations in plasticity-related-gene-1 (PRG-1) protein contribute to hippocampal seizure susceptibility and modify epileptic phenotype. Cereb Cortex 33, 7454-7467. doi:10.1093/cercor/bhad051.
- Lubomirov LT, Mantke R, Enzmann T, Metzler D, Korotkova T, Hescheler J, Pfitzer G, and Grisk O (2023). ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries. J Hypertens 41, 1201-1214. doi:10.1097/HJH.0000000000003450.
- Petzold A, van den Munkhof HE, Figge-Schlensok R, and Korotkova T (2023). Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs. Cell Metab 35, 456-471 e456. doi:10.1016/j.cmet.2023.02.008.