Krüger, Marcus - assoc. RG 40
Quantitative Proteomics
Prof. Dr. Marcus Krüger
Institute for Genetics | CECAD Research Center
CMMC - PI - assoc. RG 40
Head - CECAD / CMMC Proteomics Facility
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Institute for Genetics | CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Cologne
Introduction
The research focus of our group is the development and application of quantitative proteomics methods in various biological fields. The aim of our study is to analyze protein dynamics and post-translational modifications (PTMs) in cellular networks under regular and pathological conditions, such as type 2 diabetes mellitus, muscle weakness and neurodegenerative diseases. We are also interested in using stable isotope incorporation in living animals to study protein dynamics by mass spectrometry.
For information about Prof. Krüger's research and work, please visit the following page: Krüger Lab
Affiliations
Publications generated during 1/2023-12/2025 with CMMC affiliation
2025
- Joaquim M, Altin S, Bulimaga MB, Simões T, Nolte H, Bader V, Franchino CA, Plouzennec S, Szczepanowska K, Marchesan E, Hofmann K, Krüger M, Ziviani E, Trifunovic A, Chevrollier A, Winklhofer KF, Motori E, Odenthal M, Escobar-Henriques M. Mitofusin 2 displays fusion-independent roles in proteostasis surveillance. Nat Commun. 2025 Feb 10;16(1):1501. doi: 10.1038/s41467-025-56673-5. PMID: 39929801; PMCID: PMC11811173.
- Holtzhausen C, Heil L, Klingel K, Fox H, Gummert J, Gärtner A, Schmidt A, Krüger M, Kirfel G, van der Ven PFM, Milting H, Clemen CS, Schröder R, Fürst DO, Tiesmeier J. Sudden cardiac death, arrhythmogenic cardiomyopathy and intercalated disc pathology due to reduced filamin C protein levels: a matter of life and death. Hum Mol Genet. 2025 Feb 3:ddaf014. doi: 10.1093/hmg/ddaf014. Epub ahead of print. PMID: 39895064.
- Schmidt L, Antczak P, Krüger M. Protocol for generating protein profiles and distance-based network analysis of murine tissue slices. STAR Protoc. 2025 Jan 17;6(1):103578. doi: 10.1016/j.xpro.2024.103578. Epub ahead of print. PMID: 39826117.
2024
- Beielstein AC, Izquierdo E, Blakemore S, Nickel N, Michalik M, Chawan S, Brinker R, Bartel HH, Vorholt D, Albert L, Nolte JL, Linke R, Costa Picossi CR, Sáiz J, Picard F, Florin A, Meinel J, Büttner R, Diefenhardt P, Brähler S, Villaseñor A, Winkels H, Hallek M, Krüger M, Barbas C, Pallasch CP. Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition. Cell Rep Med. 2024 Dec 17;5(12):101830. doi: 10.1016/j.xcrm.2024.101830. Epub 2024 Nov 26. PMID: 39603243; PMCID: PMC11722127.
- Chopra S, Kadiri OL, Ulke J, Hauffe R, Jonas W, Cheshmeh S, Schmidt L, Bishop CA, Yagoub S, Schell M, Rath M, Krüger J, Lippert RN, Krüger M, Kappert K, Kleinridders A. DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways. Cell Rep. 2024 Dec 24;43(12):114984. doi: 10.1016/j.celrep.2024.114984. Epub 2024 Nov 26. PMID: 39589923.
- Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dązbrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüeger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W. Author Correction: A heterotypic assembly mechanism regulates CHIP E3 ligase activity. EMBO J. 2024 Mar;43(6):1110-1111. doi: 10.1038/s44318-024-00042-3. Erratum for: EMBO J. 2022 Aug 1;41(15):e109566. doi: 10.15252/embj.2021109566. PMID: 38388749; PMCID: PMC10943065.
- In 't Groen SLM, Franken M, Bock T, Kruger M, de Greef JC and Pijnappel W (2024). A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle. Skelet Muscle 14(1): 3.
- Veronese M, Kallabis S, Kaczmarek AT, Das A, Robers L, Schumacher S, Lofrano A, Brodesser S, Muller S, Hofmann K, Kruger M, and Rugarli EI (2024). ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway. Life Sci Alliance7. doi:10.26508/lsa.202402620.
- Zeinert I, Schmidt L, Baar T, Gatto G, De Giuseppe A, Korb-Pap A, Pap T, Mahabir E, Zaucke F, Brachvogel B, Krüger M, Krieg T, Eckes B. Matrix-mediated activation of murine fibroblast-like synoviocytes. Exp Cell Res. 2025 Feb 1;445(1):114408. doi: 10.1016/j.yexcr.2025.114408. Epub 2025 Jan 5. PMID: 39765309.
2023
- Shi F, de Fatima Silva F, Liu D, Patel HU, Xu J, Zhang W, Turk C, Kruger M, and Collins S (2023). Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning. Mol Metab 74, 101753. doi:10.1016/j.molmet.2023.101753.
- Stachelscheid J, Jiang Q, Aszyk C, Warner K, Bley N, Muller T, Vydzhak O, Symeonidis K, Crispatzu G, Mayer P, Blakemore SJ, Goehring G, Newrzela S, Hippler S, Robrecht S, Kreuzer KA, Pallasch C, Kruger M, Lechner A, Fischer K, Stilgenbauer S, Beutner D, Hallek M, Auguin D, Huttelmaier S, Bloehdorn J, Vasyutina E, and Herling M (2023). The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL. Blood 141, 1425-1441. doi:10.1182/blood.2022015494.
- van der Wal E, Iuliano A, In 't Groen SLM, Bholasing AP, Priesmann D, Sharma P, den Hamer B, Saggiomo V, Kruger M, Pijnappel W, and de Greef JC (2023). Highly contractile 3D tissue engineered skeletal muscles from human iPSCs reveal similarities with primary myoblast-derived tissues. Stem Cell Reports 18, 1954-1971. doi:10.1016/j.stemcr.2023.08.014.
- Zhu M, Metzen F, Hopkinson M, Betz J, Heilig J, Sodhi J, Imhof T, Niehoff A, Birk DE, Izu Y, Kruger M, Pitsillides AA, Altmuller J, van Osch G, Straub V, Schreiber G, Paulsson M, Koch M, and Brachvogel B (2023). Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation. iScience 26, 107225. doi:10.1016/j.isci.2023.107225.