Krüger, Marcus - assoc. RG 40

Quantitative Proteomics

Prof. Dr. Marcus Krüger
Prof. Dr. Marcus Krüger

Institute for Genetics - CECAD Research Center

CMMC - PI - assoc. RG 40

Head - CECAD / CMMC Proteomics Facility

Institute for Genetics - CECAD Research Center

Joseph-Stelzmann-Str. 26

50931 Cologne

Introduction

The research focus of our group is the development and application of quantitative proteomics methods in various biological fields. The aim of our study is to analyze protein dynamics and post-translational modifications (PTMs) in cellular networks under regular and pathological conditions, such as type 2 diabetes mellitus, muscle weakness and neurodegenerative diseases. We are also interested in using stable isotope incorporation in living animals to study protein dynamics by mass spectrometry.

For information about Prof. Krüger's research and work, please visit the following page: Krüger Lab

2024 (up to June)
  • Das A, Thapa P, Santiago U, Shanmugam N, Banasiak K, Dązbrowska K, Nolte H, Szulc NA, Gathungu RM, Cysewski D, Krüeger M, Dadlez M, Nowotny M, Camacho CJ, Hoppe T, Pokrzywa W. Author Correction: A heterotypic assembly mechanism regulates CHIP E3 ligase activity. EMBO J. 2024 Mar;43(6):1110-1111. doi: 10.1038/s44318-024-00042-3. Erratum for: EMBO J. 2022 Aug 1;41(15):e109566. doi: 10.15252/embj.2021109566. PMID: 38388749; PMCID: PMC10943065.
     
  • Veronese M, Kallabis S, Kaczmarek AT, Das A, Robers L, Schumacher S, Lofrano A, Brodesser S, Muller S, Hofmann K, Kruger M, and Rugarli EI (2024). ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway. Life Sci Alliance7. doi:10.26508/lsa.202402620.
2023
  • Shi F, de Fatima Silva F, Liu D, Patel HU, Xu J, Zhang W, Turk C, Kruger M, and Collins S (2023). Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning. Mol Metab 74, 101753. doi:10.1016/j.molmet.2023.101753.
     
  • Stachelscheid J, Jiang Q, Aszyk C, Warner K, Bley N, Muller T, Vydzhak O, Symeonidis K, Crispatzu G, Mayer P, Blakemore SJ, Goehring G, Newrzela S, Hippler S, Robrecht S, Kreuzer KA, Pallasch C, Kruger M, Lechner A, Fischer K, Stilgenbauer S, Beutner D, Hallek M, Auguin D, Huttelmaier S, Bloehdorn J, Vasyutina E, and Herling M (2023). The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL. Blood 141, 1425-1441. doi:10.1182/blood.2022015494.
     
  • van der Wal E, Iuliano A, In 't Groen SLM, Bholasing AP, Priesmann D, Sharma P, den Hamer B, Saggiomo V, Kruger M, Pijnappel W, and de Greef JC (2023). Highly contractile 3D tissue engineered skeletal muscles from human iPSCs reveal similarities with primary myoblast-derived tissues. Stem Cell Reports 18, 1954-1971. doi:10.1016/j.stemcr.2023.08.014.
     
  • Zhu M, Metzen F, Hopkinson M, Betz J, Heilig J, Sodhi J, Imhof T, Niehoff A, Birk DE, Izu Y, Kruger M, Pitsillides AA, Altmuller J, van Osch G, Straub V, Schreiber G, Paulsson M, Koch M, and Brachvogel B (2023). Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation. iScience 26, 107225. doi:10.1016/j.isci.2023.107225.