Pasparakis, Manolis - B 09
Role of autophagy in the regulation of ZBP1-mediated cell death and inflammation
Prof. Dr. Manolis Pasparakis
Institute for Genetics - CECAD
CMMC - PI - B 09
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Institute for Genetics - CECAD
Joseph-Stelzmann-Str. 26
50931 Cologne
Introduction
For information about Prof. Pasparkis' research and work, please visit the following page: Pasparkis Lab
Affiliations
Publications generated during 1/2023-12/2025 with CMMC affiliation
2024 (up to June)
- Eren RO, Kaya GG, Schwarzer R, and Pasparakis M (2024). IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun15, 130. doi:10.1038/s41467-023-44372-y.
- Imai T, Lin J, Kaya GG, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, and Pasparakis M (2024). The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. doi:10.1016/j.immuni.2024.04.016.
- Injarabian L, Willenborg S, Welcker D, Sanin DE, Pasparakis M, Kashkar H, and Eming SA (2024). FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6C(high) Wound Macrophages from Damaged Tissue. J Invest Dermatol144, 152-164 e157. doi:10.1016/j.jid.2023.06.203.
- Koerner L, Wachsmuth L, Kumari S, Schwarzer R, Wagner T, Jiao H, and Pasparakis M (2024). ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death Differ. doi:10.1038/s41418-024-01321-6.
- Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Kruger M, Frezza C, Heeren J, Trifunovic A, and Pasparakis M (2024). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature625, 385-392. doi:10.1038/s41586-023-06857-0.
2023
- Imanishi T, Unno M, Yoneda N, Motomura Y, Mochizuki M, Sasaki T, Pasparakis M, and Saito T (2023). RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Sci Adv 9, eadd6097. doi:10.1126/sciadv.add6097.
- Injarabian L, Willenborg S, Welcker D, Sanin DE, Pasparakis M, Kashkar H, and Eming SA (2024). FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6C(high) Wound Macrophages from Damaged Tissue. J Invest Dermatol 144, 152-164 e157. doi:10.1016/j.jid.2023.06.203.
- Koerner L, Schmiel M, Yang TP, Peifer M, Buettner R, and Pasparakis M (2023). NEMO- and RelA-dependent NF-kappaB signaling promotes small cell lung cancer. Cell Death Differ 30, 938-951. doi:10.1038/s41418-023-01112-5.
- Schorn F, Werthenbach JP, Hoffmann M, Daoud M, Stachelscheid J, Schiffmann LM, Hildebrandt X, Lyu SI, Peltzer N, Quaas A, Vucic D, Silke J, Pasparakis M, and Kashkar H (2023). cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J 42, e113614. doi:10.15252/embj.2023113614.