News

Prof. Klußmann Elected to DKG Certification Commission

08/04/2026 | ENT specialist assumes co-chair of certification program for head and neck cancer centers

New Molecular Target Identified in High-Risk Neuroblastoma

06/04/2026 | Study Indicates Potential Efficacy of FGFR Inhibitors in Tumors with FGFR1 Mutation

New Hope for Small Cell Lung Cancer: Advances in CAR-T Cell Therapy

02/04/2026 | An international research team led by the University Hospital and Medical Faculty of Cologne has made significant progress in fighting a particularly aggressive form of lung cancer: small cell lung cancer (SCLC). The project is funded by North Rhine-Westphalia and the EU with two million euros.

Protein complex protects central RNA quality control from disruption

31/03/2026 | Researchers at the University of Cologne show that three different proteins work together as a complex to maintain the cell’s quality control / publication in “Nucleic Acid Research”

Three Research Track Project Awards presented

09/03/2026 | Promising doctoral theses honored - On March 4, 2026, doctoral students Anna-Maria Baleff, Jule Müller, and Ellen Weber were honored with the Research Track Project Award from the Faculty of Medicine.

A new “molecular switch” for inborn immunity identified

06/03/2026 | Researchers have discovered a previously unknown signalling cascade that determines how powerful our innate immune system responds to virus infections. This discovery has broad implications for inflammatory diseases, cancer, and neurodegeneration

How faulty mRNA is destroyed

06/03/2026 | Researchers from the University of Cologne and the Max Planck Institute of Biochemistry show that the targeted interaction of two proteins ensures that a key control mechanism in the formation of proteins functions with precision

1.06 million for joint project on salivary gland carcinomas

25/02/2026 | MoSaic project investigates molecular resistance mechanisms / German Cancer Aid is funding a joint project on salivary gland carcinomas with €1.06 million. The funds are being granted as part of the 12th call for proposals (2025) for the “Translational Oncology” funding priority.

BMFTR funds Advanced Cologne Clinician Scientist Program (AdCCSP)

25/02/2026 | Focus on progress in age-related diseases / The Federal Ministry of Research, Technology, and Space (BMFTR) is providing a total of €11.8 million over 10 years to fund a program focused on age-related diseases for clinically active specialists with research ambitions at the Faculty of Medicine.

Artificial DNA base pair developed based on halogen bonds

20/02/2026 | A research team at the University of Cologne has developed an artificial DNA base pair that works according to a new chemical principle. In contrast to natural bases, the novel artificial base pairs use halogen bonds that are enzymatically incorporated into DNA / publication in the ‘Journal of the American Chemical Society’

Novel HIV antibody identified

18/02/2026 | New prospects for vaccine and therapeutic development against HIV-1 - An international research team has identified a novel HIV antibody that attacks the virus at a particularly vulnerable site, overcoming the limitations of known antibodies.

False alarm in newborn screening: how zebrafish can prevent unnecessary SMA therapies

13/02/2026 | Studies show for the first time how functional tests can clarify genetic false alarms and protect families from irreversible therapies and substantial costs

New drug reduces tumor volume in mouse model for aggressive lung cancer

06/02/2026 | Deltafluorine shows initial success in treating difficult-to-treat form of cancer

Rita Schmutzler appointed new president of German Cancer Aid

30/01/2026 | Physician and scientist succeeds Anne-Sophie Mutter - The Board of Trustees and Executive Board of German Cancer Aid have elected Prof. Rita Schmutzler as the new president of the non-profit organization.

Jane Reznick receives ‘Proof of Concept’ grant from the European Research Council

28/01/2026 | The NEWHEART projects develop a new treatment option after heart attacks. ERC funding of 150,000 euros over 18 months allows researchers to explore the commercial or societal potential of their work

New joint project approved in SFB 1607

19/01/2026 | Cooperation with anesthesiology in new glaucoma project on iron metabolism in the eye - The Collaborative Research Center (SFB) 1607, which focuses on age-related blinding eye diseases, is the only SFB in Germany's field of ophthalmology funded by the German Research Foundation (DFG).

Inflammation fuels one of the most aggressive forms of cancer

23/12/2025 | Researchers at the University of Cologne discovered a new mechanism used by one of the most aggressive forms of lung cancer to escape treatment, paving the way for more efficient future therapies

Over €5 million for Innovative Therapy Against Hospital Germs - GO-Bio Next Funding for Cologne Research Team

18/12/2025 | The Cologne-based research project, INNOPAK, aims to develop innovative, precise antibodies to fight infections caused by antibiotic-resistant "Pseudomonas aeruginosa" bacteria.

Prof. Cursiefen Receives Bjerrum Medal - Honor from the Danish Ophthalmological Society

15/12/2025 | During its winter meeting at the Reichshospital in Copenhagen, the Danish Ophthalmological Society (DOS) awarded the prestigious Bjerrum Medal to University Professor Dr. Claus Cursiefen,

STOP PKD - Study investigates a new treatment option for people with the most common form of genetic kidney disease

12/12/2025 | Scientists have initiated a study to investigate whether dapagliflozin, an already approved drug from the SGLT2 inhibitors group, can positively affect the course of autosomal dominant polycystic kidney disease (ADPKD)

Animal behaviour: AI can help fill the gap

05/12/2025 | Researchers from Cologne developed an AI method to recover missing data from animal movement recordings and to efficiently quantify behaviour / publication in “Nature Methods”

Prof. Baldus receives award from the Fritz Acker Foundation

04/12/2025 | Outstanding achievements in medical research for the Director of the Department of Cardiology at the Heart Center of Cologne University Hospital and Executive Board Member at the Center for Molecular Medicine Cologne

Possible therapeutic approach to treat diabetic nerve damage discovered

28/11/2025 | Researchers have decoded the signalling pathway that inhibits nerve regeneration in diabetes and have developed a therapeutic peptide that could transform the treatment - and possibly even the prevention - of diabetic nerve damage / published in Science Translational Medicine.

Patients and Cologne University Hospital work hand in hand on research

19/11/2025 | The University Hospital Cologne has partnered with the patient organizations "ALK Positive Europe" and "ZIELGENAU" to pioneer research into a rare form of lung cancer.

University of Cologne and CMMC scientists among the most highly cited researchers worldwide

13/11/2025 | The University of Cologne is once again represented in the international ranking of ‘Highly Cited Researchers’, which is published annually by Clarivate Analytics based on information from the ‘Web of Science’ publication database.

Blood-based immunological signatures for extrapulmonary tuberculosis decoded

11/11/2025 | First biomarkers for rapid diagnosis and targeted therapy / Tuberculosis (TB) is one of the world's leading infectious diseases. Infection with the bacterium "Mycobacterium tuberculosis" primarily affects the lungs, but in up to 25 percent of all infected individuals, it also affects other parts of the body, such as the lymph nodes, bones, or brain.

ERC Synergy Grant for virologist Florian Klein and physicist Michael Lässig

06/11/2025 | In a joint project, the two University of Cologne scientists are investigating mutations of viral pathogens in connection with the immune response. The European Research Council awards ERC Synergy Grants to interdisciplinary groups of two to four excellent researchers.

Over half a million euros in DFG funding for Miguel Alejandre Alcazar & Julian Wagner

05/11/2025 | Over half a million euros in funding from the German Research Foundation (DFG) goes to Prof. Dr. Miguel Alejandre Alcazar (Translational Experimental Pediatrics, Department of Pediatrics, associated to the CMMC, University Hospital Cologne Institute for Lung Health, Justus Liebig University Giessen) and Dr. Julian Wagner (Institute of Cardiovascular Regeneration, Goethe University Frankfurt)

Research into alternatives to antibiotics wins award in the category of basic research

04/11/2025 | Antibodies against virulence factors of "Pseudomonas aeruginosa" could become an alternative to antibiotics in the future. A team from Cologne University Hospital has been awarded the 2025 "Galenus von Pergamon Prize" for basic research for its work in this field.

From food to fuel: How leucine enhances mitochondrial energy production

03/11/2025 | Researchers from the University of Cologne discovered how a specific dietary amino acid increases cellular energy, opening new possibilities for treating metabolic diseases

Researchers Establish a New Standard for Studying Leukemia – Macrophage Interactions in vitro

31/10/2025 | A research team from the UKK and the CMMC has developed and systematically compared macrophage co-culture systems in chronic lymphocytic leukemia (CLL). The study provides the first comprehensive analysis of these models and proposes a new experimental standard for reproducible investigations into leukemia-microenvironment interactions.

Leptin-sensing brain circuit helps overcome anxiety to meet vital needs

21/10/2025 | A research team at the University of Cologne and University Hospital Cologne identifies a circuit in the brain that counteracts anxiety and helps to restore balanced behaviour. The result could contribute to developing treatment options for anorexia nervosa, one of the deadliest mental illnesses.

Prof. Schommers Receives EACS Research Prize at European AIDS Conference

17/10/2025 | This year's Prize for European HIV Research (ANRS MIE Award for the Best Basic/Translational Paper on HIV) goes to Prof. Dr. Dr. Philipp Schommers, Clinic I for Internal Medicine at Cologne University Hospital and associated to the Center of Molecular Medicine Cologne (CMMC).

Researchers identify clues that link mechanism to the most common hereditary neurological disease

14/10/2025 | A new study shows that disease-causing changes in the MFN2 gene in Charcot-Marie-Tooth syndrome trigger programmed cell death – a potential key to understanding the incurable nerve disease / publication in “Journal of Cell Science”

Clinical development of drugs for antibiotic resistance begins

09/10/2025 | Additional €1.55 million from the Else Kröner-Fresenius-Stiftung - Antibiotic resistance is one of the greatest medical challenges of our time. Infections with multi-resistant pathogens are increasingly leading to severe disease progression, long hospital stays, and rising mortality rates.

Immunomodulation: A Promising Therapy for Diabetic Retinopathy

07/10/2025 | A new study by the Laboratory for Experimental Immunology of the Eye at Cologne University Hospital and the Faculty of Medicine reveals new, promising methods for preventing eye damage in diabetic retinopathy (DR) by targeting the immune response within the retina.

Antibody discovered that blocks almost all known HIV variants in neutralization assays

07/10/2025 | A Cologne-led research team has discovered the antibody 04_A06, which neutralizes the human immunodeficiency virus (HIV) in almost all tested variants in vitro and even overcomes typical resistance mechanisms. The discovery potentially opens up new perspectives for the prevention and treatment of HIV infections.

Prof. Klein receives Hamburg Science Award 2025

06/10/2025 | University Professor Florian Klein, Director of the Institute of Virology at Cologne University Hospital, Executive Board Member at the Center for Molecular Medicine Cologne (CMMC) and a leading international expert in human immunodeficiency virus (HIV), has been awarded the 2025 Hamburg Science Prize for his work on immunomodulation.

A quiet ally: a ubiquitin precursor promotes stress resistance and longevity

02/10/2025 | In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and neurodegenerative diseases

How synapses stick together

22/09/2025 | Scientists in Cologne offer a molecular perspective on the architecture of a synapse. They have discovered that a protein in the brain forms flexible filaments, thereby acting as an essential building block of inhibitory synapses.

Fat cells have a natural defence system against diabetes, liver disease and ageing

18/09/2025 | A molecular protective mechanism keeps fat cells healthy, protects against metabolic diseases and plays an important role during the ageing process / These findings could contribute to better early detection and treatment in the future / Publication in ‘Science Advances’

Microbial allies: Bacteria help fight against cancer

15/09/2025 | An international team of scientists have discovered that microbes associated with tumours produce a molecule, which can control cancer progression and boost the effectiveness of chemotherapy / publication in "Cell Systems".

Cellular quality control in humans decoded

11/09/2025 | A research team at the University of Cologne and the Max Delbrück Center in Berlin has deciphered in detail the rules behind an important mechanism of cellular quality control in humans / Publication in ‘Molecular Cell’

Wired to Grow: How Small Cell Lung Cancer Hijacks Neuronal Synapses

11/09/2025 | Researchers reveal that lung cancer cells form direct synapses with neurons to grow and proliferate, opening the door to new therapies that cut the communication lines / publication in ”Nature”

Carien Niessen elected new Vice-Rector for Research at the University of Cologne

09/09/2025 | On September 8, the University Election Assembly — consisting of an equal number of members of the Senate and members of the University of Cologne’s University Council — elected Professor Dr Carien Niessen as Vice-Rector for Research.

Cologne University Hospital implants novel mitral valve prosthesis for the first time

05/09/2025 | At the Heart Center of Cologne University Hospital, the team of doctors led by Prof. Stephan Baldus, Director of Department III for Internal Medicine, Matti Adam, and Dennis Mehrkens has successfully implanted a Sapien M3 mitral valve prosthesis for the first time in North Rhine-Westphalia.

How aging drives neurodegenerative diseases

03/09/2025 | A University of Cologne research team has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation

Inhibiting programmed cell death to treat a rare childhood disease

21/08/2025 | A preclinical study at the University of Cologne could open up new treatment options for STING-associated vasculopathy with onset in infancy (SAVI) and benefit a wide spectrum of other currently therapy-resistant genetic diseases

Summer fun with sun safety: UV-Schutz im Freibad by the Project DIE SONNE UND WIR, in collaboration with KölnBäder.

18/08/2025 | The Skin Cancer Prevention Project DIE SONNE UND WIR is running the "UV-Schutz im Freibad – Mach den Sonnencheck" campaign to raise awareness of UV protection, in collaboration with KölnBäder.

New Leadership for Young Immunologists

06/08/2025 | Dr. Sebastian Theobald and Louise M. Cremer take on key board roles at the Young Immunologists of the German Society for Immunology (DGfI).

Please find more CMMC news in our news archive.