Center for Molecular Medicine Cologne

Dear Members of the CMMC Community
dear Members of the Life Science Campus at the University of Cologne,

It gives us pleasure to welcome you and your group members as well as interested members of the Medical Faculty and Science Faculty to the CMMC Annual Retreat 2024 at the Tagungszentrum - Erzbistum Köln in Siegburg. The retreat starts on Thursday - Feb. 29, 2024 at 10 a.m. and ends on Friday - March 01, 2024 at 2.30 p.m.

We are delighted that the Vice Rector for Research of the University of Cologne - Prof. Dr. Claus Cursiefen, will be opening the CMMC Annual Retreat with a welcome address.

As in previous years, the program of the CMMC Annual Retreat 2024 will be organized by members of the CMMC Junior Faculty. Many thanks to the organizers RobertHänsel-Hertsch - Felix Hoyer - Hien Nguyen - Simon Pöpsel for their great commitment.

As in previous years, the CMMC Annual Retreat 2024 program is once again organized by members of the CMMC Junior Faculty. Thanks to the organizers, Robert Hänsel-Hertsch, Felix Hoyer, Hien Nguyen, and Simon Pöpsel for puttting togeather such a great program that strengthens scienctific exchange and networking. We also extend a warm thank you to all the CMMC scientists for their participation in the short or flash talk sessons or at their posters.

The organizers are thrilled to announce that Professor Dr. Anna Köttgen from the Medical Center - University of Freiburg will be our honorary speaker for the CMMC Lecture. Her presentation is titled 'The value of population studies for translational research'.

We are looking forward to a highly interactive meeting.

With best regards

Thomas Benzing (Chair of the CMMC) and the Members of the CMMC Executive Board

We are thrilled to announce that Professor Dr. Anna Köttgen (University of Freiburg) will be our honorary speaker for the CMMC Lecture. Her talk is titled 'The value of population studies for translational research`.
Anna Köttgen is a physician and epidemiologist who directs the Institute of Genetic Epidemiology at the Medical Center - University of Freiburg. She is also the spokesperson of the DFG-funded CRC 1453 (“Nephrogenetics”).
Her research focuses on complex genetic traits and diseases, particularly kidney and metabolic diseases. Anna Köttgen has done an amazing job linking genetic, molecular, and clinical data from participants in large patient and population studies.
Her work has led to important scientific contributions to the understanding of physiological kidney function. She has also identified a large number of previously unknown risk genes for kidney disease and metabolic disorders such as gout. Anna leads several large research collaborations, for example the international CKDGen Consortium Meta Analysis Data."

 

 

 

Program

9.00 - 10.20 a.m.

Meeting of the CMMC Executive Board (for members of the EC Board only)
 

10.30 - 10.45 a.m.

Welcome Address - CMMC Annual Retreat 2024

Claus Cursiefen - Vice Rector for Research, University of Cologne

Thomas Benzing - Chair of the Center for Molecular Medicine Cologne

Brief introduction of the program

Robert Hänsel-Hertsch - Felix Hoyer - Hien Nguyen - Simon Pöpsel
The organizers of the scientific program - CMMC Annual Retreat 2024

 

Short Talks Session I

CMMC Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control
of cell proliferation and tissue invasion
Chairs: Axel Hillmer and Hien Nguyen

10.45 - 11.00 p.m.

Genetic determinants of clinical outcome in neuroblastoma
Matthias Fischer
Department of Exp. Pediatric Oncology - Clinic of Pediatric and Adolescent Medicine

11.00 - 11.15 a.m.

Overactive Akt and Notch signaling in MZ B cells causes liver cancer
F Thomas Wunderlich
Clinic for Endocrinology, Diabetology and Preventive Medicine & Max Planck Institute for Metabolism Research

11.15 - 11.30 a.m. .

Targeting the necroptosis pathway in pancreatic cancer
Silvia von Karstedt
Department of Translational Genomics

11.30 - 11.45 a.m.

Nrf2 signaling: a decision between death and life
Reinhard Büttner and Vangelis Kondylis
Institute for General Pathology and Pathological Anatomy

11.45 - 12.00 p.m.

Long noncoding repetitive RNAs and their role in therapy resistance
Michal R Schweiger

Institute for Translational Epigenetics

12.00 - 1.30 p.m.
Lunch Break

Flash Talks Session I

CMMC Junior Research groups
Chairs - Felix Hoyer and Thomas Benzing

1.30 - 2.30 p.m.

P 07 - Serum proteomics from the 3H-study suggests a role of complement activation for the lower risk of cardiovascular disease in hemodiafiltration patients over hemodialysis
Konstantin Bunte - member of the RG P Antczak

P 09 - Apoptotic keratinocytes regulate adipocyte lipolysis and dWAT dynamic during skin tissue regeneration
Deborah Delbue da Silva - member of the RG C Niemann

P 25 - Understanding the role of ribosome UFMylation in translation-arrested protein degradation
Schinya Ibrahim
- member of the RG D Trentini

P 27 - AKR1C3 enhances radioresistance in esophageal adenocarcinoma cells via inhibiting ferroptosis
Feng Ju - member of the RG Y Zhao / C Bruns

P 31 - Regulation of cell death and inflammatory response through proteolytic events
Ina Lisewski
- member of the RG A Annibaldi

P 35 - The mitotic surveillance pathway in stem cells
Charlotte Meyer-Gerards
- member of the RG H Bazzi

P 37 - SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency
Thibaut Molinie
- member of the RG E Rugarli  

P 39 - Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination
Julie Mudler
- member of the RG J Rybniker

P 41 - OXPHOS deficiency causes activation of the immune system through increase in heme flux
Nidhi Nair
- member of the RG A Trifunovic

P 45 - Activation of automethylated PRC2 by dimerization on chromatin
Egor Pavlenko
- member of RG S Pöpsel

P 49 - Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma
Marta Pistone
- member of the RG A Hillmer

P 59 - Structural and functional characterization of the regulatory cascade controlling mitochondrial fission in mitosis
Hirak Naitik Tailor
- member of the RG V Piano

P 61 - Investigating the potential regulatory effects of protein kinases Lyn and Csk in the tumor-supportive macrophages of non-small cell lung cancers
Thanh Tung Truong
- member of the RG H Nguyen

P 67 - GDF15 as a potential target for overcoming cancer-associated fibroblast mediated treatment resistance in esophageal adenocarcinoma
Yue Zhao - head of the RG Y Zhao / C Bruns

2.30 - 4.15 p.m.        Poster Session I

Short Talk Session II

Chair - Thomas Benzing

4.15 - 4.30 p.m.

Cell death regulation during tissue repair
Alessandro Annibaldi
Center for Molecuar Medicine Cologne

4.30 - 4.45 p.m.

Unraveling the complex mechanisms of polycomb regulation
Simon Pöpsel
Center for Molecuar Medicine Cologne

4.45 - 5.00 p.m.

Accelerated progerin-driven aging causes G-quadruplex DNA breakage
Robert Hänsel-Hertsch
Center for Molecuar Medicine Cologne

5.00 - 5.30 p.m.

Coffee Break

CMMC Key Note Lecture

5.30 - 6.30 p.m.

The value of population studies for translational research
Anna Köttgen
Institute of Genetic Epidemiology - Medical Center, University Freiburg

Moderation Hien Ngyuen - Clinic I of Internal Medicine

7.00 p.m.

CMMC Dinner

9.00 - 10.30 a.m.

Short Talk Session III

CMMC Research Areas B: Principles of immunity, inflammation and infection
Chairs: Nieves Peltzer and Robert Hänsel-Hertsch

9.00 - 9.15 a.m.

Targeting the immune checkpoint molecule BTLA in glomerulonephritis
Bastian Trinsch I Sebastian Brähler I Paul Brinkkötter
Clinic II of Internal Medicine

9.15 - 9.30 a.m.

Antigenic variation impacts gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces
Berenike Maier1I Paul Higgins2
Institute for Biological Physics1 andInstitute for Medical Microbiology, Immunology and Hygiene2

9.30 - 9.45 a.m.

Retinal microglia and their immunological effects in AAV-based ocular gene therapy
Thomas Langmann
Lab. for Experimental Immunology of the Eye - Clinic of General Ophthalmology -

9.45 - 10.15 a.m.

CMMC Report I General Assembly
Thomas Benzing
Chair - Center for Molecular Medicine Cologne

10.15 - 10.30  a.m.

Coffee Break

Poster Flash Talk Session II

Chairs - tba

10.30 - 11.15 a.m.

P 02 - Methylation pattern association with epigenetic signature of Peripartum Depression
Khawla Abualia
- member of the RG P Antczak

P 04 - Title pending
Salim Caglar Avci
- member of the RG B Wirth

P 20 - Designing of multifunctional 3D printed biomimetic theragenerative aerogel scaffold via mussel-Inspired chemistry
Demidov, Yan
- member of the RG H Maleki

P 22 - I’m still standing: Exploring ribosome stalling in protein quality control at the ER
Tom Eisenack
- member of the RG D Trentini

P 30 - Physiological causes of genome instability in aging: Identification and evaluation of G-loop-binding proteins
Anna E Koch
- member of the RG R Hänsel-Hertsch

P 42 - Understanding the Regulation of T Cell Immunity in B Cell Lymphoma
Mila Lobastova
- member of the RG H Nguyen

P 48 - The mt-mRNA-stabilizing protein LRPPRC regulates mitochondrial structure and function in skeletal muscle
Tang C P Pham
- member of the RG R Wiesner

P 56 - Uncovering the mechanisms regulating mitochondrial dynamics during cell division
Sebastian Voß
- member of the RG V Piano

CMMC Information
D Grosskopf-Kroiher - Claudia Herr - Simon Pöpsel
 

11.15 - 1.15 p.m.
Poster Session II with Fingerfood
 

1.15 - 2.15 p.m.
Short Talk Session IV

CMMC Research Area C: Molecular mechanisms &ánd metabolic control of tissue degeneration and regeneration
Chair: Mauro Corrado and Simon Pöpsel

1.15 - 1.30 p.m.

Mechanochemical control of skin stem cell dynamics in health and disease
Matthis Rübsam I Carien M Niessen
Department Cell Biology of the Skin

1.30 - 1.45 p.m.

Deciphering the pathomechanisms underlying spine deformities and intervertebral disc degeneration upon disrupted lipid anabolism in cells of the Nucleus pulposus
Hans-Martin Pogoda I Matthias Hammerschmidt
Dev. Biology - Institute of Zoology, Biocenter Cologne

1.45 - 2.00 p.m.

Treatments for ultra-rare metabolic disorders: a blessing and a curse
Guenter Schwarz
Institute for Biochemistry - Department Chemistry

2.00 - 2.15 p.m.

Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology
Tatiana Korotkova1I Anne Schaefer2
Institute for Vegetative Physiology1 I Max Planck Institute for Biology of Ageing2
 

2.15 - 2.30 p.m.

Final discussion and leave taking

Overview of the poster presenter(s) and poster title (Flash Talks indicated with FT)

P 01 - Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice
Al Kabbani, Aghyad - Member of RG H Zempel

P 03 - Exploring the utility of serum proteomics for outcome prediction of autosomal polycystic kidney disease (ADPKD)
Aydogan Balaban, Hande Ö - Member of the RG P Antczak

P 05 - Investigating spine abnormalities and intervertebral disc degeneration in a new teleost model lacking functional fatty-acid-synthase
Bassett, Fiona - Member of the RG M Hammerschmidt

P 07 & FT - Serum proteomics from the 3H-study suggests a role of complement activation for the lower risk of cardiovascular disease in Hemodiafiltration patients over Hemodialysis
Bunte, Konstantin - Member of the RG P Antczak

P 09 & FT - Apoptotic keratinocytes regulate adipocyte lipolysis and dWAT dynamic during skin tissue regeneration
Delbue da Silva, Deborah - Member of the RG C Niemann

P 11 - Stabilized analogues of Z-RNA and their interaction with Z-nucleic acid binding immune response proteins
Dicke, Finn - Member of the RG S Kath-Schorr

P 13 - The role of cytosolic phospholipase A 2 α in modulation of ferroptosis sensitivity
Edenhofer, Anna - Member of the RG S Karstedt

P 15 - The regulation of the lncRNA HSATIII during heat shock in Huntington's disease models
Fahad, Dewan Al - Member of the RG M R Schweiger

P 17 - Multi-effector cell targeting using bispecific single-chain variable fragments for B Cell Lymphoma
Freihammer, Max - Member of the RG S Borchmann

P 19 - Role of synaptic lipid-modulated cortical excitability in motor control - Importance for brain disorders
Götz, Jan - Member of the RG J Vogt

P 21 - Retinal microglia and their immunological effects in AAV-based ocular gene therapy
Gröger, Anna - Member of the RG T Langmann

P 23 - Linear ubiquitination in metabolic inflammation
Hyoubi, Armel - Member of the RG N Peltzer

P 25 & FT - Understanding the role of ribosome UFMylation in translation-arrested protein degradation
Ibrahim, Schinya - Member of the RG Trentini Schmidt

P 27 - AKR1C3 enhances radioresistance in esophageal adenocarcinoma cells via inhibiting ferroptosis
Ju, Feng - Member of the RG C Bruns

P 29 - Functional role of tumor-specific B-cells and tertiary-lymphoid structures in preclinical models of immune checkpoint therapy
Lehmann, Jonas - Member of the RG H Schlößer

P 31 & FT - Regulation of cell death and inflammatory response through proteolytic events
Lisewski, Ina - Member of the RG A Annibaldi

P 33 - Cytokine profiling in health and diseases
Mahabir-Brenner, Esther - PI

P 35 & FT - The mitotic surveillance pathway in stem cells
Meyer-Gerards, Charlotte - Member of the RG H Bazzi

P 37 & FT - SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency
Molinie, Thibaut - Member of the RG E Rugarli

P 39 & FT - Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination
Mudler, Julie - Member of the RG J Rybniker

P 41 & FT - OXPHOS deficiency causes activation of the immune system through increase in heme flux
Nair, Nidhi - Member of the RG A Trifunovic

P 43 - Transcript quality effects of RNAPII speed variation
Papadakis, Antonios - Member of the RG A Beyer

P 45 & FT- Activation of automethylated PRC2 by dimerization on chromatin
Pavlenko, Egor - Member of the RG S Pöpsel

P 47 - Loss of SIRT7 promotes G-quadruplex DNA mediated genome instability in the Hutchinson Gilford Progeria Syndrome
Piccirillo, Priscilla - Member of the RG R Hänsel-Hertsch

P 49 - Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma
Pistone, Marta - Member of the RG A Hillmer

P 51 - Structure and regulatory interactions of human histone demethylase KDM5B
Rüngeler, Till - Member of the RG S Pöpsel

P 53 - Deciphering the contribution of inflammatory macrophages in focal segmental glomerulosclerosis
Sierra-Gonzalez, Claudio - Member of the RG S Brähler

P 55 - Title pending
Solagna, Francesca - Member of the RG F Cabreiro

P 57 - Development and synthesis of artificial nucleotide signals to target immunometabolism in plants
Strippel, Julian - Member of the RG S Kath-Schorr

P 59 & FT - Structural and functional characterisation of the regulatory cascade controlling mitochondrial fission in mitosis
Tailor, Hirak Naitik - Member of RG V Piano

P 61 & FT - Investigating the potential regulatory effects of protein kinases Lyn and Csk in the tumor-supportive macrophages of non-small cell lung cancer
Truong, Thanh Tung - Member of the RG P-H Nguyen

P 63 - Investigating the role of Par3B in podocyte polarity in the kidney
Vaddavalli, Pavana Lakshmin - Member of the RG P T Brinkkötter

P 65 - 3D Printing of biocompatible and antibacterial silica-silk-based hybrid aerogel scaffolds incorporated with propolis
Vaseghi, Akbar - Member of the RG H Maleki

P 67 & FT - GDF15 as a potential target for overcoming cancer-associated fibroblast mediated treatment resistance in esophageal adenocarcinoma
Zhao, Yue - Member of the RG C Bruns

P 69 - Pathobiological characterization of pulmonary hypertension associated with heart failure with preserverd ejection fraction
Zimmermann, Lea - Member of the RG S Rosenkranz

P 71 - Effects of the AIS proteins Ankyrin G and TRIM46 on TAU sorting
Zempel, Hans - PI

 

Overview of the poster presenter(s) and poster title (Flash Talks inidcated with FT)

P 02 & FT - Methylation pattern association with epigenetic signature of peripartum depression
Abualia, Khawla - Member of the RG P Antczak

P 04 & FT - Title pending
Avci, Salim Caglar - Member of the RG V Piano

P 06 - Understanding the role of cFLIP in the pathogenesis of Diffuse Large B Cell Lymphoma (DLBCL)
Bariboloka, Kristie - Member of the RG A Annibaldi

P 08 - Changing the game: Next-Generation DNAzymes for antiviral therapies
Behn, Tobias - Member of the RG S Kath-Schorr 

P 10 - The TAU isoform 1N4R mediates Amyloid beta-induced neuronal dysfunction in human neurons
Benitez, David - Member of the RG H Zempel

P 12 - Functional analysis of nuclear stress body formation and SATIII RNA response after HPV E2 related alteration
Bergmann, Larissa - Member of The RG M R Schweiger

P 14 - ERBB2 signalling inhibits MHC Class I antigen presentation pathway and enables immune cell evasion in Small Cell Lung Cancer
Bouchez, Cyrielle - Member of the RG R Ullrich

P 16 - A preclinical study with patient-derived fibroblasts to develop clinically translatable therapies for Alpers/ POLG-spectrum disorders and related mitochondriopathies
Cakmak, Cagla - Member of the RG H Zempel

P 18 - Bi2S3 nanobelts or MXene-integrated silk fibroin-based self-assembly-driven 3D-Printed theragenerative scaffolds for remotely photothermal anti-osteosarcoma ablation and bone regeneration
Chen, Shiyi - Member of the RG H Maleki

P 20 & FT - Multifunctional 3D printed biomimetic theragenerative scaffold with anti-bacterial, anti-Osteosarcoma and osteoinductive properties
Demidov, Yan - Member of RG H Maleki

P 22 & FT - I’m still standing: Exploring ribosome stalling in protein quality control at the ER
Eisenack, Tom - Member of the RG D B Trentini Schmidt

P 24 - Addition of Durvalumab to neoadjuvant chemoradiotherapy (CROSS) in esophageal adenocarcinoma is feasible and safe - first results from the prospective Phase-II RICE trial
Garcia-Marquez, Maria A - Member of the RG H A Schlößer

P 26 - Transcriptomic profiling in chronic lymphocytic leukemia
Grimm, Christina - Member of the RG M R Schweiger

P 28 - Towards 3D human cardiac tissues - identification of a human epicardial biomarker
Junghof, Julia - Member of RG K P Pfannkuche

P 30 & FT  - Physiological causes of genome Iistability in aging: Identification and evaluation of G-loop-binding Proteins
Koch, Anna Eva - Member of the RG Hänsel-Hertsch

P 32 - Detecting transcriptional mistakes from single-cell RNA-seq data
Koubele, Jakub - Member of the RG A Beyer

P 34 - Which modification provides a higher translation efficiency of mRNA?
Kulko, Ekaterina - Member of the RG Kath-Schorr

P 36 - The role of ferroptosis in diffuse large B-cell lymphoma (DLBCL) subtypes
Langpape, Anuschka - Member of RG S Karstedt

P 38 - lncRNA in pathogenesis of focal segmental glomerulosclerosis
Lemsara, Amira - Member of the RG  Antczak

P 40 - A translational approach to study Autosomal Recessive Polycystic Kidney Disease
Liebau, Max C - PI

P 42 & FT - Understanding the regulation of T Cell Immunity in B Cell Lymphoma
Lobastova, Mila - Member of the RG P-H Nguyen

P 44 - A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
Müller, Leonie - Member of the RG T  Hoppe

P 46 - Assessing the role of olfactory receptor 2 in diet-induced obesity animal model
Park, Yein I Ruhlmann, Jonathan - Member of the RG H Winkels

P 48 & FT - The mt-mRNA-stabilizing protein LRPPRC regulates mitochondrial structure and function in skeletal muscle
Pham, Tang Cam Phung - Member of the RG R Wiesner

P 50 - Mitochondrial ROS sensitize podocytes to insulin resulting in mTOR activation
Reitmeier, Katrin - Member of the RG P T Brinkkötter

P 52 - Mechanochemical control of skin stem cell dynamics in health and disease
Rübsam, Matthias - Member of the RG C M Niessen

P 54  Ultrasensitive ctDNA-Seq in PCNSL
Schneider, Jessica - Member of the RG of S Borchmann

P 56 - Developing and testing a single cell hapatocyte damage score
Unger Avila, Paula - Member of the RG A Beyer

P 58 & FT - Uncovering the mechanisms regulating mitochondrial dynamics during cell division
Voß, Sebastian - Member of the RG V Piano

P 60 - Tertiary lymphoid structures in pancreatic cancer resemble lymphoid follicles in secondary lymphoid organs as sites for initiation and maintenance of anti-tumor T- and B-cell responses
Wennhold, Kerstin - Member of the RG H A  Schlößer

P 62 - Gonococcal aggregation causes differential expression of genes involved in antibiotic tolerance
Wielert, Isabelle - Member of the RG B Maier

P 64 - Evaluation of the efficiency and reliability of artificial intelligence (AI) for endoscopic diagnosis of Esophageal Squamous Cell Carcinoma (ESCC): A systematic review and Meta-analysis
Xu, Yinan - Member of the RG Y Zhao

P 66 - Expanding the repertoire of cleavable and uncleavable bifunctional linker systems for applications in targeted RNA delivery
Zips, Niclas - Member of the RG S Kath-Schorr

P 68 - Proximity based interactomes of HSF1 under distinct stress conditions
Zirden, Linda - Member of the RG S Pöpsel

P 70 - Role of cFLIP in cell death suppression to maintain tissue homeostasis
Zrilic, Matea - Member of the RG A  Annibaldi

P 72 - D-Aspartate treatment of B6N spermatozoa increases male fertility by ROS production
Peltier, Manon - Member of the RG E Mahabir-Brenner

 

 

Tagungszentrum des Erzbistums Köln
Bergstr. 26
53721 Siegburg

https://www.ksi-institut.de/start/

 

The conference site is located 45 km east of Cologne. For your convenience we will offer a shuttle service.

Time table for the bus shuttle:
Feb. 29, 2024: 9:00 a.m. - departure from the CMMC-Research Building, Robert-Koch-Str. 21
Mar. 01, 2024: 2:30 p.m. - departure from KSI Siegburg to Cologne

From Cologne Hbf / main train station oder Köln Messe/Deutz you can take S12 or S19 to Siegburg Bahnhof. From there it is a short walk up the hill to KSI, Bergstrasse 26, 53721 Siegburg.

For directions please visit the following link:

http://tinyurl.com/CMMC-KSI

Please note: destination address for navigation system: Bergstrasse 26, 53721 Siegburg

Parking garage on site

The participation in the CMMC Annual Retreat is free. The CMMC will finance the CMMC Annual Retreat 2024 from central CMMC accounts.

Please note that your registration is a binding commitment, and we kindly request that you consider this when registering.

Registration is closed and no more rooms available!

Poster - CMMC Annual Retreat 2024

CMMC Lecture

Feb. 29, 2024 at 5:30 - 6:30 p.m.
The value of population studies for translational research
Prof. Dr. Anna Köttgen
Institute of Genetic Epidemiology -  Medical Center, University Freiburg