9.45 - 11.10. a.m.

Meeting of the CMMC Executive Board (for members of the EC Board only)

11.20 - 11.40 a.m.

Welcome Address and General Assembly

Thomas Benzing    Chair - Center for Molecular Medicine Cologne

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Chair: Sandra Iden - CECAD Cologne

11.40 - 12.00 a.m.

A 02 - The functional and therapeutic significance of activated telomerase in neuroblastoma
Matthias Fischer - Dept. of Children and Adolescent Medicine

12.00 - 12.20 p.m.

A 03 - Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies Phoung-Hien Nguyen / Michael Hallek - Dept. I of Internal Medicine

12.20 - 12.40 p.m.

A 05 - Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias
Elena Vasyutina / Marco Herling - Dept. I of Internal Medicine

12.40 - 2.20 p.m.

Lunch Break with Poster Session

Chair: Catherin Nieman - Institute II for Biochemistry and CMMC

2.20 - 2.40 p.m.

B 4 - The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation
Hamid Kashkar - Institute for Medical Microbiology, Immunology and Hygiene

2.40 - 3.00 p.m.

A11 - Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer
Martin Sos - Institute for Pathology and Dept. of Translational Genomics

3.00 - 3.20 p.m.

A 12 - Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis
Mirka Uhlirova - Institute for Genetics and CECAD Cologne

3.20 - 3.40 p.m.

Coffee Break with Poster Session

Research Area B: Principles of immunity, inflammation and infection

Chair: Claus Cursiefen - Dept. of Ophtalmology

3.40 - 4.00 p.m.

B 3 - Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency
Deniz Hos / Claus Cursiefen / Felix Bock - Dept. of Ophthalmology

4.00 - 4.20 p.m.

B 5 - Chronic inflammatory responses to persistent cytoplasmic DNA
Ashley Williams / Björn Schumacher - Institute for Genome Stability in Aging & Disease, CECAD

4.20 - 4.40 p.m.

Coffee Break with Poster Session

Junior Research Groups

Chair: Martin Krönke - CMMC Vice Chair, Inst. for Med. Microbiology, Immunology and Hygiene

4.40 - 5.00 p.m.

JRG - Functional annotation of vertebrate genomes in development and disease
Alvaro Rada-Iglesias - Lab. of Developmental Genomics, CMMC

5.00 - 5.20 p.m.

JRG - Changes in 3D chromatin organization upon cellular senescence
Argyris Papantonis - Lab. of Systems Biology of Chromatin, CMMC

5.20 - 5.40 p.m.

Centriole integrity is essential for Drosophila male germline stem cells development
Jay Gopalakrishnan - Lab. of Centrosome and Cytoskeleton Biology, CMMC

5.40 - 6.00 p.m.

Coffee Break with Poster Session

6.00 - 7.00 p.m. - Key Note Lecture

Powering axons: a novel function of oligodendrocytes
Klaus-Armin Nave - Max Planck Institute for Experimental Medicine, Göttingen

Laudatio: Wilhelm Stoffel - Lab. for Laboratory of Mol. Neuroscience, Inst. for Biochemistry

at 8.00 p.m. - CMMC Dinner

Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Chair: Bernhard Schermer - Dept. of Internal Medicine

9.00 - 9.20 a.m.

C 1 - Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney
Bodo Beck¹ / Janine Altmülller² - Institute for Human Genetics¹ / Cologne Center for Genomics²

9.20 - 9.40 a.m.

C 3 - Role of astrocytes in microvasculature remodeling following brain injury
Matteo Bergami - CECAD Cologne

9.40 - 10.00 a.m.

C 4 - Contribution of deteriorating RNA biosynthesis to cellular ageing
Andreas Beyer¹ / Argyris Papantonis² - CECAD Cologne¹ and CMMC²

10.00 - 10.20 a.m.

Coffee Break with Poster Session

Chair: Brunhilde Wirth - Inst. for Human Genetics

10.20 - 10.40 a.m.

C 8 - Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex
Dirk Isbrandt¹ / Adele M Rüger² / Michael Schroeter² / Igor Jakovcevski¹
Institute for Molecular and Behavioral Neuroscience¹ / Dept. of Neurology²

10.40 - 11.00 a.m.

C 10 - Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration
Carien Niessen - Dept. of Dermatology and CECAD Cologne

11.00 - 11.20 a.m.

C 15 - Manipulation of CLPP protease to complement mitochondrial respiratory deficiency
Aleksandra Trifunovic - Institute for Mitochondrial Diseases and Ageing and CECAD Cologne

11.20 - 11.40 a.m.

Coffee Break with Poster Session

Career Advancement and Junior Research Groups (part II)

Chair: Guenter Schwarz - Vice Chair of the CMMC, Inst. for Biochemistry

11.40 - 12.00 p.m.

CAP 2 - Modelling the activity of transcription factors
Mathieu Clement-Ziza - CECAD Cologne and CMMC

12.00 - 12.20 p.m.

CAP 3 - Mechanisms of axonal injury in neuroinflammation and neurotoxicity
Helmar Lehman - Dept. of Neurology and CMMC

12.20 - 12.40 p.m.

JRG - Translational approaches to Muscular Dystrophy
Sebahattin Cirak - Dept. for Pediatrics and Adolescent Medicine and CMMC

12.40 - 1.00 p.m.

Final discussion and leave-taking
Thomas Benzing - Chair, Center for Molecular Medicine Cologne