Center for Molecular Medicine Cologne


Dear CMMC Members

It is a great pleasure for us to welcome you and your group members to the CMMC Annual Retreat taking place from Jan. 26 - 27, 2017 at the Tagungsstätte „Park-Hotel Nümbrecht“. The retreat starts on Thursday - Jan. 26, 2017 at 11 a.m. and ends on Friday - Jan. 27, 2017 presumably at 1.00 p.m.

We are looking forward to a highly interactive meeting.

With best regards

Thomas Benzing
Chair of the CMMC and the EC Members

Program: short talks and poster presentation

Over 46 research groups, five core facilities, the IPMM program complemented by additional research related activities are supported and integrated in the CMMC.

Based on a rotation system every year, a limited number of project groups are invited to present a progress report. To further facilitate the scientific exchange within the CMMC all CMMC project leaders and heads of the core facilities are invited to present a poster during the CMMC poster sessions. The poster sessions will take place during the coffee and lunch breaks at the foyer directly in front of the seminar room.

Key Note Lecture: Prof. Dr. Klaus-Armin Nave - MPI for Exp. Medicine, Göttingen, DE

We are delighted to announce that Prof. Dr. Klaus-Armin Nave (MPI for Exp. Medicine, Göttingen) accepted our invitation to participate in the Annual Retreat as honoary key note lecturer. The Key Note Lecture with following title: Powering Axons: a Novel Function of Oligodendrocytes will take place on Jan. 26, 2017 at 6.00 p.m.

Short Curriculum Vitae and Publications

Program - Annual Retreat 2017

9.45 - 11.10. a.m.

Meeting of the CMMC Executive Board (for members of the EC Board only)

11.20 - 11.40 a.m.

Welcome Address and General Assembly

Thomas Benzing    Chair - Center for Molecular Medicine Cologne

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Chair: Sandra Iden - CECAD Cologne

11.40 - 12.00 a.m.

A 02 - The functional and therapeutic significance of activated telomerase in neuroblastoma
Matthias Fischer - Dept. of Children and Adolescent Medicine

12.00 - 12.20 p.m.

A 03 - Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies Phoung-Hien Nguyen / Michael Hallek - Dept. I of Internal Medicine

12.20 - 12.40 p.m.

A 05 - Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias
Elena Vasyutina / Marco Herling - Dept. I of Internal Medicine

12.40 - 2.20 p.m.

Lunch Break with Poster Session

Chair: Catherin Nieman - Institute II for Biochemistry and CMMC

2.20 - 2.40 p.m.

B 4 - The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation
Hamid Kashkar - Institute for Medical Microbiology, Immunology and Hygiene

2.40 - 3.00 p.m.

A11 - Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer
Martin Sos - Institute for Pathology and Dept. of Translational Genomics

3.00 - 3.20 p.m.

A 12 - Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis
Mirka Uhlirova - Institute for Genetics and CECAD Cologne

3.20 - 3.40 p.m.

Coffee Break with Poster Session

Research Area B: Principles of immunity, inflammation and infection

Chair: Claus Cursiefen - Dept. of Ophtalmology

3.40 - 4.00 p.m.

B 3 - Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency
Deniz Hos / Claus Cursiefen / Felix Bock - Dept. of Ophthalmology

4.00 - 4.20 p.m.

B 5 - Chronic inflammatory responses to persistent cytoplasmic DNA
Ashley Williams / Björn Schumacher - Institute for Genome Stability in Aging & Disease, CECAD

4.20 - 4.40 p.m.

Coffee Break with Poster Session

Junior Research Groups

Chair: Martin Krönke - CMMC Vice Chair, Inst. for Med. Microbiology, Immunology and Hygiene

4.40 - 5.00 p.m.

JRG - Functional annotation of vertebrate genomes in development and disease
Alvaro Rada-Iglesias - Lab. of Developmental Genomics, CMMC

5.00 - 5.20 p.m.

JRG - Changes in 3D chromatin organization upon cellular senescence
Argyris Papantonis - Lab. of Systems Biology of Chromatin, CMMC

5.20 - 5.40 p.m.

Centriole integrity is essential for Drosophila male germline stem cells development
Jay Gopalakrishnan - Lab. of Centrosome and Cytoskeleton Biology, CMMC

5.40 - 6.00 p.m.

Coffee Break with Poster Session

6.00 - 7.00 p.m. - Key Note Lecture

Powering axons: a novel function of oligodendrocytes
Klaus-Armin Nave - Max Planck Institute for Experimental Medicine, Göttingen

Laudatio: Wilhelm Stoffel - Lab. for Laboratory of Mol. Neuroscience, Inst. for Biochemistry

at 8.00 p.m. - CMMC Dinner

Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Chair: Bernhard Schermer - Dept. of Internal Medicine

9.00 - 9.20 a.m.

C 1 - Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney
Bodo Beck1 / Janine Altmülller2 - Institute for Human Genetics1 / Cologne Center for Genomics2

9.20 - 9.40 a.m.

C 3 - Role of astrocytes in microvasculature remodeling following brain injury
Matteo Bergami - CECAD Cologne

9.40 - 10.00 a.m.

C 4 - Contribution of deteriorating RNA biosynthesis to cellular ageing
Andreas Beyer1 / Argyris Papantonis2 - CECAD Cologne1 and CMMC2

10.00 - 10.20 a.m.

Coffee Break with Poster Session

Chair: Brunhilde Wirth - Inst. for Human Genetics

10.20 - 10.40 a.m.

C 8 - Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex
Dirk Isbrandt1 / Adele M Rüger2 / Michael Schroeter2 / Igor Jakovcevski1
Institute for Molecular and Behavioral Neuroscience1 / Dept. of Neurology2

10.40 - 11.00 a.m.

C 10 - Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration
Carien Niessen - Dept. of Dermatology and CECAD Cologne

11.00 - 11.20 a.m.

C 15 - Manipulation of CLPP protease to complement mitochondrial respiratory deficiency
Aleksandra Trifunovic - Institute for Mitochondrial Diseases and Ageing and CECAD Cologne

11.20 - 11.40 a.m.

Coffee Break with Poster Session

Career Advancement and Junior Research Groups (part II)

Chair: Guenter Schwarz - Vice Chair of the CMMC, Inst. for Biochemistry

11.40 - 12.00 p.m.

CAP 2 - Modelling the activity of transcription factors
Mathieu Clement-Ziza - CECAD Cologne and CMMC

12.00 - 12.20 p.m.

CAP 3 - Mechanisms of axonal injury in neuroinflammation and neurotoxicity
Helmar Lehman - Dept. of Neurology and CMMC

12.20 - 12.40 p.m.

JRG - Translational approaches to Muscular Dystrophy
Sebahattin Cirak - Dept. for Pediatrics and Adolescent Medicine and CMMC

12.40 - 1.00 p.m.

Final discussion and leave-taking
Thomas Benzing - Chair, Center for Molecular Medicine Cologne


Park-Hotel Nümbrecht
Parkstr. 3 - 51588 Nümbrecht

Bus Shuttle

The conference site - located 50 km east of Cologne in the Oberberg area - is difficult to reach by public transport.

Time table of the bus shuttle:
February 06, 2019: 9:00 a.m. - Departure from the CMMC-Research Building, Robert-Koch-Str. 21

February 07, 2019: 2:00 p.m. - Departure from the Park-Hotel Nümbrecht to Cologne

Directions by car

Please visit following link:

Please note: destination address for navigation system: Weiherstrasse, 51588 Nümbrecht