Center for Molecular Medicine Cologne

CMMC Annual Retreat 2021 goes hybrid

Dear CMMC Members,
Dear Members of the Medical Faculty, the Science Faculty and associated Research Institutions at the University of Cologne,

It is a great pleasure for us to invite you to the CMMC Annual Retreat 2021 held in a hybrid format taking place on February 03 and February 04, 2021. The Hybrid Program of the CMMC Annual Retreat 2021 integrates

  • 1st day (Feb. 03, 2021): the CMMC Report (General Assembly), 12 short talks of CMMC Principal Investigators and the CMMC Lecture
  • 2nd day (Feb. 04, 2021): three workshops organized by the CMMC Junior Research Group Leaders with the on-site participation of the roundtable workshop group and followed by a general CMMC meeting, where the outcomes of the three workshops will be presented

Following formats will be provided:

  • online participation
  • live streaming of the on-site events taking place in the CMMC Seminar Room
  • live Q&A during the sessions and workshops
  • breakout channels and group chats to further promote the scientific exchange and networking
  • virtual poster session - further information will follow shortly

We are looking forward to a highly interactive hybrid meeting.

With best regards

Thomas Benzing
Chair of the CMMC and the EC Members

We are delighted to announce that Prof. Dr. Anja Schneider (Dept. for Neurodegenerative Diseases and Geriatric Psychiatry, Univ. Hospital Bonn & DZNE, Bonn) has accepted our invitation to participate in the Annual Retreat as honorary lecturer of the CMMC Lecture 2021.

The CMMC Lecture "Extracellular Vesicles in Neurodegeneration and Diseases" presented by Prof. Dr. Anja Schneider will take place on February 03, 2021 at 5.00 p.m.

Anja Schneider and her research group investigate the role of extracellular vesicles (EVs) in neurodegenerative diseases: We are especially interested in EV mediated release of toxic, aggregated proteins, such as tau and alpha-Synuclein, the determinants of their sorting into EVs and the contribution of their release to toxicity and propagation of disease pathology throughout the brain. Biosketch - Prof. Dr. Schneider

9.30 - 10.45 a.m.

Meeting of the CMMC Executive Board

(for members of the EC Board only)

Seminar Room

Scientific Program - CMMC Annual Retreat 2021

11.00 - 11.20 a.m.

Welcome address and CMMC Progress Report
Thomas Benzing - Chair of the Center for Molecular Medicine Cologne

Research Area A - Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Chair: pending

11.20 - 11.40 a.m.

B 08  - The role of antigen-presenting cell subtypes in anti-Leishmania immunity
Esther von Stebut-Borschitz | Nir Yogev
Clinic & Polyclinic of Dermatology and Venerology

11.40 a.m - 12.00 p.m.

A 03 - The role of MAP2K7 inactivation in malignant transformation of neuroblastoma
Matthias Fischer
Department of Experimental Pediatric Oncology

12.00 - 12.20 p.m

A 04 - Understanding the impact of the lymphoid microenvironment in B cell malignancies by single-cell analysis
Michael Hallek | Phuong-Hien Nguyen | Rocio Rebollido-Rios
Clinic I of Internal Medicine

12.20 - 12.40 p.m.

A 06 - Elucidation of ferroptosis-inducing therapy (FIT) for the treatment of pancreatic cancer
Silvia von Karstedt
Department for Translational Genomics

12.40 - 1.40 p.m.

Lunch Break with
Breakout Rooms for Discussions

Research Area B - Principles of immunity, inflammation and infection

Chair - pending

1.40 - 2.00 p.m.

B 02 - Mechanism of the “Abscopal Effect” upon Radiation Therapy (RT)
Grit Herter-Sprie1 | Jan Herter2 | Roland Ullrich1
1Clinic I of Internal Medicine - 2Dept. of Radiation Therapy, Radiooncology and Cyberknife

2.00 - 2.20 p.m.

B 05 - Microglia modulation as target for diabetic retinopathy
Thomas Langmann
Clinic of General Ophthalmology

2.20 - 2.40 p.m.

A 02 - Role of MFN2 in CMT2A neurodegeneration and in NAFLD liver disease
Mafalda Escobar-Henriques1 | Margarete Odenthal2 
1Institute for Genetics - 2Institute for Pathology

2.40 - 3.00 p.m.

B 06 - Correlating biofilm structure with antibiotic tolerance
Berenike Maier1 | Paul Higgins2
1Inst. for Biological Physics - 2Inst. for Med. Microbiology, Immunology and Hygiene

3.00 - 3.20 p.m.

Coffee Break with
Breakout Rooms for Discussions

Research Area C - Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Chair: pending

3.20 - 3.40 p.m.

C 01 - Netrin-1 as a new target to treat chronic lung disease: Identification of agonists and antagonists by artificial intelligence
Miguel A Alejandre Alcazar1 | Manuel Koch2
1Clinic & Polyclinic for Paediatric and Adolescent Medicine - 2Inst. for Oral and Musculoskeletal Biology

3.40 - 4.00 p.m.

C 07 - Molecular mechanism of X-linked intellectual disability caused by mutations in the UPF3B gene
Niels Gehring
Institute for Genetics

4.00 - 4.20 p.m.

C 10 - Regulation of feeding in health and pathology by glucagon-like peptide-1 receptor-expressing cells in the lateral hypothalamus and the lateral septum
Tatiana Korotkova
Institute of Vegetative Physiology

4.20 - 4.40 p.m.

C 13 - Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways
Elena Rugarli
Institute for Genetics / CECAD Research Center

4.40 - 5.00 p.m.

Coffee Break

5.00 - 6.00 p.m.   

CMMC Lecture

Laudatio - pending
Extracellular vesicles in neurodegenerative diseases
Anja Schneider
Clinic for Neurodegenerative Diseases and Geriatric Psychiatry | Univ. Hospital Bonn & German Center for Neurodegenerative Diseases (DZNE) - Bonn

CMMC Workshop Sessions

  • organized by the CMMC Junior Research Group Leaders
  • livestreaming of the on-site roundtable discussions with the organizers and the on-site participants in the CMMC Seminar Room
  • interactive digital participation for all CMMC members and scientists of the Life Science Campus at the University of Cologne
8.30 - 11.00 a.m.

Workshop 1 
Integrative data handling for improved human health research
Katarzyna Bozek1and Philipp Antczak2
1CMMC-Lab. of Data Science of Bioimages and 2CMMC-Lab. of Computational Biology of Aging

University Hospital Cologne is a large and diverse hub for biomedical research. Integrative analysis of the vast amounts of data generated on the campus can provide means for improved personalized medicine, offer the potential to extract novel understanding of biology, improve patient stratification and welfare. The goal of this workshop is to devise an integrated analytical system encompassing the diverse clinical and experimental data flows. Inherent to our discussion will be the removal of boundaries throughout the organization to inspire new integrative research projects and comprehensive (re)use of the rich biomedical datasets generated on the campus.
On-site - CMMC Seminar Room: Organizers and 10 invited participants (pending)

11.00 - 1.30 p.m.

Workhop 2
Assembly, regulation and dynamics of multi-subunit complexes in cellular signaling

Alessandro Annibaldi1  -  Débora B Trentini2  -  Simon Pöpsel3
1CMMC-Lab. of Cell Death, Inflammation and Immunity  - CMMC Lab. Protein Quality Control and Stress Response 3CMMC-Lab. of Structure and Biochemistry of Epigenetic Regulators

Proteins exert their function as part of larger, multi-subunit assemblies. The analysis of such assemblies is of crucial importance to understand their function at a larger scale, although often challenging due to the limitations of individual approaches.

We will discuss the strengths and limitations of our experimental approaches, and how collaborative efforts could help us drawing a more detailed picture of our favorite biological systems. We will particularly focus on i) Cryo-EM, ii) Cross-linking mass spectrometry and iii) Single Cell Imaging to study the dynamics & molecular details of multi-subunit protein complexes.
On-site participants for the roundtable discussions - CMMC Seminar Room:
Kay Hofmann (Institute for Genetics) - Ron Jachimowicz (Clinic I for Internal Medicine, MPI for Biology of Ageing and CMMC) - Hamid Kashkar (Inst. for Med. Microbiology, Immunology & Hygiene and CMMC) - Natalia Kononenko (CECAD) - Ana Garcia Saez (Inst. for Geentics and CECAD) - Guenter Schwarz (Institute for Biochemistry and CMMC) - Gerhard Sengle (Center for Biochemistry, Med. Faculty-and CMMC) NNs (pending) and the Organizer

2.00 - 4.30 p.m.

Workhop 3
Targeted treatment of patients through single-cell multi-OMICs Profiling

Robert Hänsel-Hertsch1and Philipp Antczak2
1CMMC-Lab. of Genome Biology and 2 CMMC-Lab. of Computational Biology of Aging

Human wellbeing is governed by the individual's (epi)genetic background, their molecular complexity & their interaction with the environment both internal and external. Improving personalized medicine requires not only identifying the molecular causes but also conceptualizing these. Here we explore how cellular composition reflects on disease predisposition, state and outcome; how multi-OMICs profiling may help in conceptualizing human disease; and how we can make use of frameworks in translational clinical applications. We aim to highlight the use of single-cell Seq and integration to improve diagnosis and treatment.
On-site - CMMC Seminar Room: Organizers and 10 invited participants (pending)

4.30 - 5.30 p.m.

General CMMC Assembly

Reports from the workshops 1-3 presented by the organizers

Final discussion and leave-taking
Thomas Benzing - Chair of the CMMC

prel. Program - CMMC Annual Retreat 2021

CMMC Lecture

Feb. 03, 2021 at 5.00 p.m.
Prof. Dr. Anja Schneider (DZNE, Bonn)
Extracellular Vesicles in Neurodegeneration and Diseases

Online registration

For organizational details we kindly ask you to register as soon as possible:

Overview of the Workshops

Feb. 04, 2021:

8.30 - 11.00 a.m.

WP 1  Integrative data handling for improved human health research
Katarzyna Bozek and Philipp Antczak

11.00 - 1.30 p.m.

WP 2 Assembly, regulation and dynamics of multi-subunit complexes in cellular signaling
Alessandro Annibaldi and Simon Pöpsel

2.00 - 4.30 p.m.

WP 3 Targeted treatment of patients through single-cell multi-OMICs Profiling
Robert Hänsel-Hertsch and Philipp Antczak