Workshop 2
Organizers
Alessandro Annibaldi - CMMC-Lab. of Cell Death, Inflammation and Immunity
Débora B Trentini Schmidt - CMMC-Lab. Protein Quality Control and Stress Response
Simon Pöpsel - CMMC-Lab. of Structure and Biochemistry of Epigenetic Regulators
Proteins exert their function in the context of dynamic interactions with other biomolecules, typically as part of larger, multi-subunit assemblies. Interaction partners may serve as substrates, regulatory cofactors, scaffold or partners of enzymatic cross-talk. The analysis of molecular interactions and their dynamics becomes of crucial importance to study larger scale processes at the basis of cellular signaling. Available experimental approaches, however, often reveal limitations that preclude a comprehensive and mechanistic exploration of complex functions. Changing our perspective is needed to identify larger scale implications or finer mechanistic details of observed interactions. Therefore, multi-faceted strategies, bringing together scientists with different areas of expertise, are needed to fully characterize such complexes.
For example, the composition of many chromatin associated complexes has been known for decades, but the interplay of subunits and their role within the cell remain enigmatic. Similarly, cell death-mediating complexes have been increasingly characterized in terms of participating proteins and their roles. However, the three-dimensional architecture and mechanistic details of interactions within these death-promoting complexes have remained elusive to date.
Our workshop is designed to explore and exchange where we encounter such boundaries in our own research, and how, through interactions and collaborations, we could facilitate breaking such barriers. We will discuss the strengths and limitations of our experimental approaches, and how collaborative efforts could help us draw a bigger or a more detailed picture of our favorite biological systems. To analyze and visualize the dynamics and molecular details of multi-subunit protein complexes we will particularly focus on
Covering a number of biological processes, we aim to exchange different perspectives and approaches to identifying and assaying the dynamic action of proteins as they change the fate of a cell.
Digital interactive workshop via Zoom-Meeting
Alessandro Annibaldi, Débora B Trentini Schmidt and Simon Pöpsel (organizers) are pleased to welcome the on-site workshop participants (see below) and the participants who will join the workshop via Go-To-Meeting.
Participants of the roundtable discussions - digital format:
Background information:
A) General publications introducing the topic
B) Interesting publications of the organizers
Feb. 04, 2021:
8.30 - 11.00 a.m.
WP 1 Integrative data handling for improved human health research
Katarzyna Bozek and Philipp Antczak
11.00 - 1.30 p.m.
WP 2 Assembly, regulation and dynamics of multi-subunit complexes in cellular signaling
Alessandro Annibaldi, Débora B Trentini Schmidt and Simon Pöpsel
2.00 - 4.30 p.m.
WP 3 Targeted treatment of patients through single-cell multi-OMICs Profiling
Robert Hänsel-Hertsch and Philipp Antczak