Wunderlich, Thomas F - assoc. RG 73

Obesity is a steadily increasing health burden that currently affects 30% of the western population. Recently, obesity has been recognized to not only cause predisposition to classical obesity-associated disorders, such as the development of T2DM and insulin resistance, but also increase the incidence of numerous cancer entities.

Obesity is known to result in a chronic low grade pro-inflammatory state as a consequence of immune cells infiltrating white adipose tissue and liver. Moreover, this so-called metabolic inflammation in turn results in elevated circulating concentrations of cytokines such as TNFa and IL-6. Therefore, obesity-associated metabolic inflammation provides a potential link between obesity and cancer. Our group investigates these and other links in mouse models of hepatocellular and colorectal cancer.

Please find more information about Prof. Wunderlich´s research and work here.

• Center for Molecular Medicine Cologne (CMMC)
• MPI for Metabolism Research
• CECAD Cologne
• SFB1607