Stangherlin, Alessandra | assoc. RG
Circadian Control of Cellular Homeostasis in Health and Disease
Dr. Alessandra Stangherlin
Institute for Mitochondrial Diseases and Ageing | CECAD
CMMC - PI - assoc. RG
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Institute for Mitochondrial Diseases and Ageing | CECAD
Joseph-Stelzmann-Str. 26
50931 Cologne
Introduction
Our group investigates how circadian (~24 h) clocks regulate cellular homeostasis and physiology, and how their disruption contributes to ageing and disease. We focus on the spatiotemporal dynamics of metal ions and their roles in metabolic regulation, protein homeostasis, and organelle function. By integrating chronobiology, cell biology, and quantitative elemental analysis, including organelle immunopurification and inductively coupled plasma mass spectrometry (ICP-MS), we develop innovative approaches to map ionic composition across subcellular compartments, tissues, and the extracellular environment. Our research ultimately aims to uncover fundamental mechanisms linking circadian timekeeping to ionic homeostasis in health and disease.
Figure
Fig.: Cellular ion rhythms support circadian regulation of cell function, while their disruption promotes disease and ageing.
Top: In healthy cells, coordinated rhythmic ion dynamics (wavy lines) across organelles and the cytosol are aligned in time, supporting rhythmic cellular functions and overall physiological health. Bottom: Disruption or desynchronization of cellular ion rhythms leads to loss of rhythmic cell function, contributing to disease and ageing.
Lab Website
Please find more information about Dr. Stangherlin´s research and work here.
Affiliations
Publications generated during 1/2026-12/2028 with CMMC affiliations
2026
Content will be made available as soon as possible.