Motori, Elisa - assoc. JRG 10
Mitochondrial regulation of cellular function
Dr. Elisa Motori
Institute for Biochemistry
CMMC - PI - assoc. JRG 10
CMMC - Co-PI - A 02
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Institute for Biochemistry
Zülpicher Str. 47
50674 Cologne
Introduction
Mitochondria are highly dynamic organelles vital for the functioning and survival of neurons. Axonal transport of mitochondria has been suggested to sustain mitochondrial turnover at synapses as well as axonal integrity. However, how local and long-range transport of mitochondria is differentially regulated within specific sub-compartments - such as functionally distinct regions of dendritic arbors - to match precise switches in synaptic development and consolidation in vivo is poorly understood. By combining imaging and genetic approaches, in this project we will focus on the almost unique architecture of Purkinje neurons to dissect the mutual regulation of mitochondrial motility and compartment-specific synaptic functions.
Lab Website
For more information, please visit Motori Lab.
Affiliations
Publications generated during 1/2023 - 12/2025 with CMMC affiliation
2025
- García-Villegas R, Odenthal F, Giannoula Y, Bonekamp NA, Kühl I, Park CB, Spåhr H, Motori E, Levander F, Larsson NG. In vivo composition of the mitochondrial nucleoid in mice. Biochim Biophys Acta Mol Cell Res. 2025 Aug;1872(6):119955. doi: 10.1016/j.bbamcr.2025.119955. Epub 2025 Apr 15. PMID: 40246179.
- Joaquim M, Altin S, Bulimaga MB, Simões T, Nolte H, Bader V, Franchino CA, Plouzennec S, Szczepanowska K, Marchesan E, Hofmann K, Krüger M, Ziviani E, Trifunovic A, Chevrollier A, Winklhofer KF, Motori E, Odenthal M, Escobar-Henriques M. Mitofusin 2 displays fusion-independent roles in proteostasis surveillance. Nat Commun. 2025 Feb 10;16(1):1501. doi: 10.1038/s41467-025-56673-5. PMID: 39929801; PMCID: PMC11811173.
2024
- Franchino CA, Motori E, Bergami M. Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled. Signal Transduct Target Ther. 2024 Jan 1;9(1):4. doi: 10.1038/s41392-023-01730-y. PMID: 38161206; PMCID: PMC10757993.