March 12, 2025 - Program
9.15 - 10.45 a.m.
Meeting of the CMMC Executive Board
(only for members of the EC Board)
Location: Seminar Room, MTI-Lecture Hall (Venue of the CMMC Annual Retreat)
10.00 - 10.50 a.m.
Reception with Registration
For Poster Presenters: please collect your poster board number and display your poster on the designated board
11.00 - 11.15 a.m.
Welcome Address - CMMC Annual Retreat 2025
Esther von Stebut-Borschitz -Vice Dean of Science - Translation - Transfer, Faculty of Medicine
Stanislav Kopriva - Vice Dean of Research, Faculty of Mathematics and Natural Sciences
Thomas Benzing -Chair of the CMMC
Introduction to the scientific program by the organizers
Alessandro Annibaldi • Johannes Brägelmann • Sebastian Brähler • Elisa Motori • Débora Trentini Schmidt
11.15 - 12.45 p.m.
Short Talk Session I - CMMC Research Area C
Molecular mechanisms and metabolic control of tissue degeneration and regeneration
Chairs: Elisa Motori1 and Débora Trentini Schmidt2 - Institute for Biochemistry1 and CMMC2
11.15 - 11.30 a.m.
Consequences of age-related G-quadruplex formation for the fidelity of mammalian transcription
Robert Hänsel-Hertsch1and Andreas Beyer2
CMMC1 and CECAD2
11.30 - 11.45 a.m.
Cellular and molecular crosstalk in skin wound resolution
Sabine Eming and Mario Fabri
Dept. of Dermatology and Venereology
11.45 - 12.00 p.m.
Understanding the role of nonsense-mediated mRNA decay in differentiation, development and disease
Niels Gehring
Institute for Genetics
12.00 - 12.15 p.m.
The quality control Ubiquitin ligase CHIP: a key regulator of Insulin signaling, healthy aging & neuroprotection
Thorsten Hoppe
Institute for Genetics and CECAD
12.15 - 12.30 p.m.
Skin insulin-IGF signalling in health and disease
Carien Niessen
Dept. of Cell Biology of the Skin and CECAD
12.30 - 12.45 p.m.
Two are not enough: Extra base pairs in nucleic acids and their application (Research Area A)
Stephanie Kath-Schorr
Institute for Organic Chemistry (MNF)
12.45 - 2.00 p.m.
Lunch Break and Industrial Exhibition
2.00 - 3.15 p.m.
Flash Talk Session I (odd poster numbers)
Chairs: Débora Trentini Schmidt and Alessandro Annibaldi - CMMC
FT 03 - Chronic infection induces a broadly neutralizing B cell response to Elastase B of Pseudomonas aeruginosa
Albus, Alexandra -Member of Simonis´RG - Dept. I of Internal Medicine
FT 09 - Structural investigations of the human KMT2D complex
Basler, Fabian - Member of Pöpsel’s RG - CMMC
FT 11 - Overexpression of the fructose transporter SLC2A5 (GLUT5) in association with PHGDH splicing dynamics is a venetoclax resistance mechanism in acute myeloid leukemia
Blakemore, Stuart - Member of Pallasch´s RG - Dept. I of Internal Medicine
FT 15 - Helicase-mediated regulation of Yamanaka Factor-G-Quadruplex interactions in pluripotency and drug-tolerant persister cells
Dasarathan, Lokapriya - Member of Haensel-Hertsch´s RG - CMMC
FT 17 - Insights into co-translational protein quality control of polytopic membrane proteins
Eisenack, Tom - Member of Trentini Schmidt´s RG - CMMC
FT 31 - Title pending
Holm Solheim, Marie - Member of Brüning´s RG - Dept. of Endocrinology, Diabetes and Preventive Medicine & MPI for Metabolism
FT 43 - Investigating cellular and inflammatory networks in kidney development in a model for neonatal chronic lung injury
Kuiper-Makris, Centina - Member of Alejandre Alcazar´s RG - Dept. of Pediatric and Adolescent Medicine
FT 47 - Mitofusin 2 displays fusion-independent roles in proteostasis surveillance
Mohn, Marie - Member of Escobar-Henrique´s RG - Institute for Genetics
FT 49 - Training versus tolerance – Previous adjuvant exposure impairs SARS-CoV-2 spike protein directed immune responses in vitro and in vivo
Mudler, Julie - Member of Rybniker’s RG - Dept. I of Internal Medicine
FT 55 - Assessing the role of olfactory receptor 2 in a model of diet-induced obesity
Park, Yein - Member of Winkels ‘s RG - Dept. III of Internal Medicine
FT 59 - Interaction of human KDM5 histone demethylase with retinoblastoma protein
Rüngeler, Till - Member of Pöpsel´s RG - CMMC
FT 65 - Elucidate the regulatory cascade controlling mitochondrial fission in mitosis
Tailor, Hirak Naitik - Member of Piano’s RG - Institute for Human Genetics
FT 71 - Title pending
Vaseghi, Akbar - Member of Maleki’s RG - Institute for Inorganic Chemistry
CMMC Info I
CMMC New Gene - Schinya Ibrahim
CMMC Empowerment - Katarzyna Bozek and Simon Pöpsel
CMMC Sustainibility - Claudia Herr
GAMMA, Facuty of Medicine - Debora Grosskopf-Kroiher
3.15 - 5.00 p.m.
Poster Session I (P 01 - P 83) and Industrial Exhibition
with Coffee and Cake
5.00 - 5.45 p.m.
CMMC Lecture I
Understanding the metabolic cross-talk between cancer and immune cells in metastatic melanoma
Ilaria Elia, Dept. of Cellular and Molecular Medicine, KU Leuven, Leuven, BE
Chair: Elisa Motori - Institute for Biochemistry
at 5.45 p.m.
CMMC Get-Together at the venue and Industrial Exhibition
March 13, 2025 - Program
9.00 - 10.15 a.m.
Short Talk Session II - CMMC Research Areas B
Principles of immunity, inflammation and infection
Chairs: Johannes Brägelmann and Christina Ising - Inst. for General Pathology and CECAD Research Center
9.00 - 9.15 a.m.
The hidden cost of hosting a microbiome
Filipe Cabreiro, Mauro Corrado and Francesca Solagna
CECAD
9.15 - 9.30 a.m.
Cell death and immunity
Hamid Kashkar
Institute for Molecular Immunology and CECAD
9.30 - 9.45 a.m.
Antibodies and the challenge of viral diversity
Florian Klein
Institute for Virology
9.45 - 10.00 a.m.
Deciphering innate immune responses in SARS-CoV-2 infection and vaccination
Sebastian Theobald and Jan Rybniker
Dept. I of Internal Medicine
10.00 - 10.15 a.m.
Heme biogenesis flux regulates switch between inflammation and ferroptosis
Aleksandra Trifunovic
Institute for Mitochondrial Diseases and Ageing and CECAD
10.15 - 10.45 a.m.
CMMC Report
incl. announcement “Submission of project proposals – 11th CMMC Funding Period” and introduction of Central Core Facilities (MF) presented by Marten Schulte (CCF-Coordinator)
Thomas Benzing - Chair of the CMMC
10.45 - 11.00 a.m.
Coffee Break and Industrial Exhibition
11.00 - 11.45 a.m.
CMMC Lecture II
Patient-level multiomics analysis of human heart and kidney disease
Christoph Kuppe, Dept. of Nephrology, University Hospital RWTH Aachen, Aachen, DE
Chair: Sebastian Brähler - Dept. II of Internal Medicine
11.45 - 12.45 p.m.
Flash Talk Session II and CMMC Info II
Chairs: Alessandro Annibaldi and Débora Trentini Schmidt - CMMC
FT 02 - Unmasking the human AIS Proteome: on the way to decoding AIS-based TAU sorting mechanisms
Adam, Daniel - Member of Zempel’s RG - Institute for Human Genetics
FT 12 - Ajuba proteins impact on YAP/TAZ phase separation in podocytes
Inês Cabrita - Member of Schermer’s RG - Dept. II of Internal Medicine
FT 14 - Extended mitochondrial transport in neuronal dendrites maintains motor skill learning
Choi, Hae-Na - Member of Motori´s RG - Institute for Genetics
FT 16 - Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma
Demond, Hannah - Member of Hillmer´s RG - Institute for General Pathology and Pathological Anatomy
FT 22 - Exploiting liquid biopsy analyses to estimate metastatic risk in non-small cell lung cancer patients
Gewalt, Tabea - Member of Hillmer´s RG - Institute for General Pathology and Pathological Anatomy
FT 30 - Decipering the role of the immunoreceptor CD300lf in Tauopathies
Hollenbeck, Jana Caroline - Member of Isings´s RG - CECAD
FT 32 - Understanding the role of ribosome UFMylation in translation-arrested protein degradation
Ibrahim, Schinya - Member of Trentini Schmidt´s RG - Center for Molecular Medicine Cologne
FT 36 - Regulated cell death in the pathogenesis of cystic kidney diseases
Kieckhöfer, Emilia - Member of Schermer’s RG - Dept. II of Internal Medicine
FT 42 - The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation
Koyuncu, Seda - Member of Vilchez’s RG - CECAD
FT 48 - Quality control mechanisms of collagen VI assembly and secretion
Moeller, Elena - Member of Lemberg´s RG - Center for Biochemistry (MF)
FT 50 - Implication of SRRM3/ 4 in neuronal µ-Exon splicing
Mueller, Andre - Member of Gehring´s RG - Institute for Genetics
FT 52 - Essential role of SLUG during the evolution of drug tolerance in lung adenocarcinomas
Ostendorp, Jenny - Member of Haensel-Hertsch´s RG - Center for Molecular Medicine Cologne
FT 64 - Edited allogeneic CD30CARTRAC-KI-PD1KO-HLA-IKOT cells against lymphomas: preclinical development
Stripecke, Renata -Dept. II of Internal Medicine
CMMC Info II
CF - Flow Cytometry - Unit of the Central Core Facilities (CCF), Faculty of Medicine
Albert, Marie-Christine - Flow Cytometry Core, Faculty of Medicine
CF - CyTOF and Hyperion Unit
Hoffmann, Petra - Dept. I of Internal Medicine
CF - CMMC Microscopy Service - From sample to insight
Babaki, Mehrnaz - CECAD/CMMC Imaging Facility
12.45 - 1.15 p.m.
Lunch Break and Industrial Exhibition
1.15 - 2.45 p.m.
Poster Session II (P 02 - P 82)and Industrial Exhibition
2.45 - 3.45 p.m.
Short Talk Session III - CMMC Research Area A
Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion
Chairs: Sebastian Brähler1 and Roland Ullrich2 - Dept. II of Internal Medicine1 and Dept. I of Internal Medicine2
2.45 - 3.00 p.m.
Role of synaptic hijacking in SCLC brain metastatic growth
ElisaMotori1and Matteo Bergami2
CMMC1 and CECAD2
3.00 - 3.15 p.m.
Ubiquilins expose an actionable target in cancer therapy
Ron Jachimowicz
Dept. I of Internal Medicine and MPI of Ageing
3.15 - 3.30 p.m.
Mechanisms of Hedgehog-Gli signaling in mammalian skin
Catherin Niemann
CMMC and Institute for Biochemistry (MF)
3.30 - 3.45 p.m.
Essential role of macrophage-derived LYN tyrosine kinase in tumor support
Phuong-Hien Nguyen1, Renata Stripecke1 and Alessandro Annibaldi2
Dept. I of Internal Medicine1 and CMMC2
3.45 - 4.00 p.m.
Awarding the Flash Talk and Poster Prizes and Final Discussion
Speakers Short Talk Sessions
CMMC Art Project
We gratefully acknowledge the support by our industrial partners
ABclonal • INTEGRA • Macherey Nagel • Merck • New England Biolabs • Proteintech
The sponsoring (€ 450,- per company) is used for event related expenses; e.g. travel of the keynote speakers, conference handouts and event management.
Conference material provided by MedChemExpress
