Klein, Florian - assoc. RG 10

2024 (up to June)

• Dewald F, Steger G, Fish I, Torre-Lage I, Hellriegel C, Milz E, Kolb-Bastigkeit A, Heger E, Fries M, Buess M, Marizy N, Michaelis B, Suarez I, Rubio Quintanares GH, Pirkl M, Aigner A, Oberste M, Hellmich M, Wong A, Orduz JC, Fatkenheuer G, Dotsch J, Kossow A, Moench EM, Quade G, Neumann U, Kaiser R, Schranz M, and Klein F (2024). SARS-CoV-2 Test-to-Stay in Daycare. Pediatrics. doi:10.1542/peds.2023-064668.
   
• Esser PL, Quintanares GHR, Langhans B, Heger E, Bohm M, Jensen BO, Esser S, Lubke N, Fatkenheuer G, Lengauer T, Klein F, Oette M, Rockstroh JK, Boesecke C, Di Cristanziano V, Kaiser R, and Pirkl M (2024). Torque Teno Virus load is associated with CDC stage and CD4+ cell count in people living with HIV but unrelated to AIDS-defining events and Human Pegivirus load. J Infect Dis. doi:10.1093/infdis/jiae014.
   
• Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alejandre Alcazar MA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, and Bock F (2024). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biol15. doi:10.1093/jmcb/mjad062.
   
• Harries M, Jaeger VK, Rodiah I, Hassenstein MJ, Ortmann J, Dreier M, von Holt I, Brinkmann M, Dulovic A, Gornyk D, Hovardovska O, Kuczewski C, Kurosinski MA, Schlotz M, Schneiderhan-Marra N, Strengert M, Krause G, Sester M, Klein F, Petersmann A, Karch A, and Lange B (2024). Bridging the gap - estimation of 2022/2023 SARS-CoV-2 healthcare burden in Germany based on multidimensional data from a rapid epidemic panel. Int J Infect Dis139, 50-58. doi:10.1016/j.ijid.2023.11.014.
   
• Trappe M, Affeldt P, Grundmann F, Kann M, Koehler FC, Muller RU, Stippel D, Kaiser R, Knops E, Heger E, Steger G, Klein F, Kurschat C, and Di Cristanziano V (2024). Five-year single-center analysis of cytomegalovirus viremia in kidney transplant recipients and possible implication for novel prophylactic therapy approaches. Transpl Infect Dis26, e14233. doi:10.1111/tid.14233.
   
• von Maltitz P, Wettstein L, Weil T, Schommers P, Klein F, and Munch J (2024). Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies. J Virol, e0119023. doi:10.1128/jvi.01190-23.

2023

• Augustin M, Heyn F, Ullrich S, Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fatkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald SJ, and Lehmann C (2023). Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome. Front Med (Lausanne) 10, 1129288. doi:10.3389/fmed.2023.1129288.
   
• Augustin M, Stecher M, Wustenberg H, Di Cristanziano V, Sandaradura de Silva U, Picard LK, Pracht E, Rauschning D, Gruell H, Klein F, Wenisch C, Hallek M, Schommers P, and Lehmann C (2023). 15-month post-COVID syndrome in outpatients: Attributes, risk factors, outcomes, and vaccination status - longitudinal, observational, case-control study. Front Immunol 14, 1226622. doi:10.3389/fimmu.2023.1226622.
   
• Dewald F, Pirkl M, Paluschinski M, Kuhn J, Elsner C, Schulte B, Knufer J, Ahmadov E, Schlotz M, Oral G, Bernhard M, Michael M, Luxenburger M, Andree M, Hennies MT, Hafezi W, Muller MM, Kumpers P, Risse J, Kill C, Manegold RK, von Frantzki U, Richter E, Emmert D, Monzon-Posadas WO, Graff I, Kogej M, Buning A, Baum M, Teipel F, Mochtarzadeh B, Wolff M, Gruell H, Di Cristanziano V, Burst V, Streeck H, Dittmer U, Ludwig S, Timm J, and Klein F (2023). Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients. Nat Commun 14, 2835. doi:10.1038/s41467-023-38127-y.
   
• Eberhardt KA, Jung V, Knops E, Heger E, Wirtz M, Steger G, Kaiser R, Affeldt P, Holtick U, Klein F, Scheid C, and Di Cristanziano V (2023). CMV-IgG pre-allogeneic hematopoietic stem cell transplantation and the risk for CMV reactivation and mortality. Bone Marrow Transplant 58, 639-646. doi:10.1038/s41409-023-01944-2.
   
• Eser TM, Baranov O, Huth M, Ahmed MIM, Deak F, Held K, Lin L, Pekayvaz K, Leunig A, Nicolai L, Pollakis G, Buggert M, Price DA, Rubio-Acero R, Reich J, Falk P, Markgraf A, Puchinger K, Castelletti N, Olbrich L, Vanshylla K, Klein F, Wieser A, Hasenauer J, Kroidl I, Hoelscher M, and Geldmacher C (2023). Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion. Nat Commun 14, 2952. doi:10.1038/s41467-023-38020-8.
   
• Gliga S, Lubke N, Killer A, Gruell H, Walker A, Dilthey AT, Thielen A, Lohr C, Flasshove C, Krieg S, Pereira JV, Seraphin TP, Zaufel A, Daumer M, Orth HM, Feldt T, Bode JG, Klein F, Timm J, Luedde T, and Jensen BO (2023). Rapid Selection of Sotrovimab Escape Variants in Severe Acute Respiratory Syndrome Coronavirus 2 Omicron-Infected Immunocompromised Patients. Clin Infect Dis 76, 408-415. doi:10.1093/cid/ciac802.
   
• Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, and Bock F (2023). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biol. doi:10.1093/jmcb/mjad062.
   
• Harms M, Smith N, Han M, Gross R, von Maltitz P, Sturzel C, Ruiz-Blanco YB, Almeida-Hernandez Y, Rodriguez-Alfonso A, Cathelin D, Caspar B, Tahar B, Sayettat S, Bekaddour N, Vanshylla K, Kleipass F, Wiese S, Standker L, Klein F, Lagane B, Boonen A, Schols D, Benichou S, Sanchez-Garcia E, Herbeuval JP, and Munch J (2023). Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection. Sci Adv 9, eadf8251. doi:10.1126/sciadv.adf8251.
   
• Harries M, Jaeger VK, Rodiah I, Hassenstein MJ, Ortmann J, Dreier M, von Holt I, Brinkmann M, Dulovic A, Gornyk D, Hovardovska O, Kuczewski C, Kurosinski MA, Schlotz M, Schneiderhan-Marra N, Strengert M, Krause G, Sester M, Klein F, Petersmann A, Karch A, and Lange B (2023). Bridging the gap - estimation of 2022/2023 SARS-CoV-2 healthcare burden in Germany based on multidimensional data from a rapid epidemic panel. Int J Infect Dis 139, 50-58. doi:10.1016/j.ijid.2023.11.014.
   
• Henze L, Braun J, Meyer-Arndt L, Jurchott K, Schlotz M, Michel J, Grossegesse M, Mangold M, Dingeldey M, Kruse B, Holenya P, Mages N, Reimer U, Eckey M, Schnatbaum K, Wenschuh H, Timmermann B, Klein F, Nitsche A, Giesecke-Thiel C, Loyal L, and Thiel A (2023). Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity. Front Immunol 14, 1056525. doi:10.3389/fimmu.2023.1056525.
   
• Klussmann JP, Grosheva M, Meiser P, Lehmann C, Nagy E, Szijarto V, Nagy G, Konrat R, Flegel M, Holzer F, Gross D, Steinmetz C, Scherer B, Gruell H, Schlotz M, Klein F, de Aragao PA, Morr H, Al Saleh H, Bilstein A, Russo B, Muller-Scholtz S, Acikel C, Sahin H, Werkhauser N, Allekotte S, and Mosges R (2023). Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients. Sci Rep 13, 6839. doi:10.1038/s41598-023-32546-z.
   
• Korenkov M, Zehner M, Cohen-Dvashi H, Borenstein-Katz A, Kottege L, Janicki H, Vanshylla K, Weber T, Gruell H, Koch M, Diskin R, Kreer C, and Klein F (2023). Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants. Immunity 56, 2803-2815 e2806. doi:10.1016/j.immuni.2023.11.004.
   
• Kreer C, Lupo C, Ercanoglu MS, Gieselmann L, Spisak N, Grossbach J, Schlotz M, Schommers P, Gruell H, Dold L, Beyer A, Nourmohammad A, Mora T, Walczak AM, and Klein F (2023). Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals. Nat Commun 14, 7137. doi:10.1038/s41467-023-42906-y.
   
• Kretschmer AC, Junker L, Dewald F, Linne V, Hennen L, Horemheb-Rubio G, Kaiser R, Steger G, Joachim A, Schonenkorb J, Cosgun ZC, Muhlhans N, Heger E, Knops E, Leisse C, Kessel B, Heinsohn T, Rodiah I, Lange B, Ritter AL, Fries M, Kossow A, Niessen J, Dotsch J, Klein F, Rybniker J, Fatkenheuer G, and Suarez I (2023). Implementing the Lolli-Method and pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools: a pilot project. Infection 51, 459-464. doi:10.1007/s15010-022-01865-0.
   
• Luxenburger H, Reeg DB, Lang-Meli J, Reinscheid M, Eisner M, Bettinger D, Oberhardt V, Salimi Alizei E, Wild K, Graeser A, Karl V, Sagar, Emmerich F, Klein F, Panning M, Huzly D, Bengsch B, Boettler T, Elling R, Thimme R, Hofmann M, and Neumann-Haefelin C (2023). Boosting compromised SARS-CoV-2-specific immunity with mRNA vaccination in liver transplant recipients. J Hepatol 78, 1017-1027. doi:10.1016/j.jhep.2023.02.007.
   
• Radford CE, Schommers P, Gieselmann L, Crawford KHD, Dadonaite B, Yu TC, Dingens AS, Overbaugh J, Klein F, and Bloom JD (2023). Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning. Cell Host Microbe 31, 1200-1215 e1209. doi:10.1016/j.chom.2023.05.025.
   
• Schommers P, Kim DS, Schlotz M, Kreer C, Eggeling R, Hake A, Stecher M, Park J, Radford CE, Dingens AS, Ercanoglu MS, Gruell H, Odidika S, Dahlhaus M, Gieselmann L, Ahmadov E, Lawong RY, Heger E, Knops E, Wyen C, Kummerle T, Romer K, Scholten S, Wolf T, Stephan C, Suarez I, Raju N, Adhikari A, Esser S, Streeck H, Duerr R, Nanfack AJ, Zolla-Pazner S, Geldmacher C, Geisenberger O, Kroidl A, William W, Maganga L, Ntinginya NE, Georgiev IS, Vehreschild JJ, Hoelscher M, Fatkenheuer G, Lavinder JJ, Bloom JD, Seaman MS, Lehmann C, Pfeifer N, Georgiou G, and Klein F (2023). Dynamics and durability of HIV-1 neutralization are determined by viral replication. Nat Med 29, 2763-2774. doi:10.1038/s41591-023-02582-3.
   
• Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms JA, Zuber S, Kottege L, Winter S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann AM, Meyer C, Ercanoglu MS, Cramer N, Munder A, Hallek M, Fatkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Klein F, and Rybniker J (2023). Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa. Cell 186, 5098-5113 e5019. doi:10.1016/j.cell.2023.10.002.
   
• Stab V, Stahl-Hennig C, Ensser A, Richel E, Fraedrich K, Sauermann U, Tippler B, Klein F, Burton DR, Tenbusch M, and Uberla K (2023). HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells. Cell Rep Med 4, 101201. doi:10.1016/j.xcrm.2023.101201.
   
• Thibeault C, Bardtke L, Vanshylla K, di Cristanziano V, Eberhardt KA, Stubbemann P, Hillus D, Tober-Lau P, Mukherjee P, Munn F, Lippert LJ, Helbig ET, Lingscheid T, Steinbeis F, Mittermaier M, Witzenrath M, Zoller T, Pa Csg, Klein F, Sander LE, and Kurth F (2023). Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-19. JCI Insight 8. doi:10.1172/jci.insight.166711.
   
• Weber T, Dahling S, Rose S, Affeldt P, Vanshylla K, Ullrich L, Gieselmann L, Teipel F, Gruell H, Di Cristanziano V, Kim DS, Georgiou G, Koch M, Kreer C, and Klein F (2023). Enhanced SARS-CoV-2 humoral immunity following breakthrough infection builds upon the preexisting memory B cell pool. Sci Immunol 8, eadk5845. doi:10.1126/sciimmunol.adk5845.
   
• Zehner M, Alt M, Ashurov A, Goldsmith JA, Spies R, Weiler N, Lerma J, Gieselmann L, Stohr D, Gruell H, Schultz EP, Kreer C, Schlachter L, Janicki H, Laib Sampaio K, Stegmann C, Nemetchek MD, Dahling S, Ullrich L, Dittmer U, Witzke O, Koch M, Ryckman BJ, Lotfi R, McLellan JS, Krawczyk A, Sinzger C, and Klein F (2023). Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer. Immunity 56, 2602-2620 e2610. doi:10.1016/j.immuni.2023.10.009.
   
• Zhang J, Sommermann T, Li X, Gieselmann L, de la Rosa K, Stecklum M, Klein F, Kocks C, and Rajewsky K (2023). LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells. Front Immunol 14, 1331730. doi:10.3389/fimmu.2023.1331730.