Jachimowicz, Ron - assoc. RG 36
Dr. Ron Jachimowicz
Clinic I of Internal Medicine | MPI of Ageing
CMMC - PI - assoc. RG 36
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Clinic I of Internal Medicine | MPI of Ageing
Cologne Center for Genomics University of Cologne Weyertal 115 b
50931 Cologne
Introduction
Mechanisms of DNA Repair: Our cells have sophisticated repair mechanisms to repair DNA damage. With age, these DNA repair mechanisms become impaired, leading to the accumulation of DNA damage and disruption of cellular function. The goal of our research is to gain a better understanding of the relationship between DNA repair and ageing.
Lab Website
For more information, please check Max Planck Research Group Jachimowicz.
Publications generated during 1/2023-12/2025 with CMMC affiliation
2024 (up to June)
- Wagener R, Brandes D, Jung M, Huetzen MA, Bergmann AK, Panier S, Picard D, Fischer U, Jachimowicz RD, Borkhardt A, and Brozou T (2024). Optical genome mapping identifies structural variants in potentially new cancer predisposition candidate genes in pediatric cancer patients. Int J Cancer154, 607-614. doi:10.1002/ijc.34721.
2023
- Averdunk L, Huetzen MA, Moreno-Andres D, Kalb R, McKee S, Hsieh TC, Seibt A, Schouwink M, Lalani S, Faqeih EA, Brunet T, Boor P, Neveling K, Hoischen A, Hildebrandt B, Graf E, Lu L, Jin W, Schaper J, Omer JA, Demaret T, Fleischer N, Schindler D, Krawitz P, Mayatepek E, Wieczorek D, Wang LL, Antonin W, Jachimowicz RD, von Felbert V, and Distelmaier F (2023). Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence. Genet Med 25, 100836. doi:10.1016/j.gim.2023.100836.
- Flumann R, Hansen J, Pelzer BW, Nieper P, Lohmann T, Kisis I, Riet T, Kohlhas V, Nguyen PH, Peifer M, Abedpour N, Bosco G, Thomas RK, Kochanek M, Knufer J, Jonigkeit L, Beleggia F, Holzem A, Buttner R, Lohneis P, Meinel J, Ortmann M, Persigehl T, Hallek M, Calado DP, Chmielewski M, Klein S, Gothert JR, Chapuy B, Zevnik B, Wunderlich FT, von Tresckow B, Jachimowicz RD, Melnick AM, Reinhardt HC, and Knittel G (2023). Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies. Blood Cancer Discov 4, 78-97. doi:10.1158/2643-3230.BCD-22-0007.
- Tabatabai A, Arora A, Hofmann S, Jauch M, von Tresckow B, Hansen J, Flumann R, Jachimowicz RD, Klein S, Reinhardt HC, and Knittel G (2023). Mouse models of diffuse large B cell lymphoma. Front Immunol 14, 1313371. doi:10.3389/fimmu.2023.1313371.