8:30 - 9:45 a.m.

Meeting of the CMMC Executive Board

(for members of the EC Board only)

Scientific Program - CMMC Annual Retreat 2022

10:00 - 10:10 a.m.

Welcome address
Thomas Benzing - Chair of the Center for Molecular Medicine Cologne

Session I - Molecular Mechanisms of Diseases

10:10 - 10:15 a.m.

Introduction of the Research Area
Brunhilde Wirth¹ and Björn Schumacher² (Chairs)
¹Institute of Human Genectics I CMMC - C16  and ²Institute for Genome Stability in Ageing and Disease I CMMC - A11

10:15 - 10:30 a.m.

Failed translation at the ER membrane: cellular strategies and disease implications
Débora B Trentini Schmidt
Laboratory of Protein Quality Control and Stress Response I CMMC - assoc. JRG 05

10:30 - 10:45. a.m

TAU and mitochondria in neurodegenerative diseases: Human iPSC-derived neurons and gene therapy approaches
Hans Zempel
Functional Genetics of Neurodegeneration - Institute of Human Genetics

10:45 - 11:00 a.m.

Metabolic rewiring in the naked mole-rat
Jane Reznick
CECAD Research Center

11:00 - 11:10 a.m.

Digital Coffee Break

11:10 - 11:25 a.m.

Characteristics, origin and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Robert Hänsel-Hertsch
Laboratory for Genome Biology I CMMC - JRG 10

11:25 - 11:40 a.m.

Quantitative image analysis in cancer research
Katarzyna Bozek
Laboratory of Data Science of Bioimages I CMMC - assoc. JRG 04

11:40 - 11:55 a.m.

Structural insights into epigenetic multi-subunit complexes
Simon Pöpsel
Laboratory of Structure and Biochemistry of Epigenetic Regulators I CMMC - JRG 11

11:55 - 12:05 p.m.

Panel discussion with the speakers

12:05 - 12:30 p.m.

Digital Lunch Break
 

Session II - Inflammation in Tissue Repair and Cancer

12:30 - 12:35 p.m.

Introduction of the Research Area
Sabine Eming¹ and Silvia von Karstedt² (Chairs)
¹Clinic and Polyclinic of Dermatology and Venereology I CMMC - C 06 and ²CECAD Cologne | CMMC - A 06

12:35 - 12:50 p.m.

Cell death in tissue repair and viral responses
Alessandro Annibaldi
Laboratory of Cell Death, Inflammation and Immunity I CMMC - JRG 12

12:50 - 1:05 p.m.

Linear ubiquitination at the crossroad of cell death and inflammation during obesity
Nieves Peltzer
Laboratory of Cell Death and Inflammation in Health an Disease I CMMC - assoc. JRG 03
Department of Translational Genomics

1:05 - 1:20 p.m.

Involvement of p62-Keap1-Nrf2 axis in liver injury and hepatocarcinogenesis
Vangelis Kondylis
Institute for General Pathology and Pathological Anatomy I CMMC - assoc. RG 12

1:20 - 1:30 p.m.

Digital Coffee Break

1:30 - 1:45 p.m.

The role of limbal epithelial stem cells in corneal lymphangiogenic privilege and pterygium
Maria Notara
Clinic of General Ophthalmology I CMMC - CAP 15 and - A 06

1:45 - 2:00 p.m.

Targeting innate immune pathways in lung cancer
Johannes Brägelmann
MSSOC I Dept. of Translational Genomics & Inst. for General Pathology and Pathological Anatomy I CMMC - CAP 18

2:00 - 2:15 p.m.

The STING of DEATH: a cycle full of CINs
Gianmaria Liccardi
Center for Biochemistry - Medical Faculty
 

 2:15 - 2:25 p.m.

Panel discussion with the speakers

2:25 - 2:40 p.m.

Digital Coffee Break

Session III - Role of Immunity in Diseases

2:40 - 2:45 p.m.

Introduction of the Research Area
Michal-Ruth Schweiger¹and Axel Hillmer² (Chairs)
¹Institute for Translational Epigenomics I CMMC - A 12 and ²Institute for General Pathology and Pathological Anatomy I CMMC - assoc. RG 09

2:45 - 3:00 p.m.

Enhancing endogenous T cell responses to shared antigens in esophago-gastric cancer
Hans A Schlößer
Clinic of General, Visceral, Tumor and Transplantation Surgery I CMMC - CAP 12

3:00 - 3:15 p.m.

Inflammasome signaling in COVID-19 and SARS-CoV-2 vaccination
Jan Rybniker – Clinic I of Internal Medicine I CMMC - CAP 08

3:15 - 3:30 p.m.

TRI-IT – a novel tripartite immunotherapy for lung cancer
Sven Borchmann
Translational Tumor Genetics and Immunotherapy - Clinic I of Internal Medicine

3:30 - 3:40 p.m.

Digital Coffee Break

3:40 - 3:55 p.m.

Functional arrayed Crispr/Cas9 screen identifies novel protein kinase targets in tumor-supportive macrophages
Phuong-Hien Nguyen
Clinic I of Internal Medicine I CMMC - CAP 19 and A 04

3:55 - 4:10 p.m.

Olfactory receptor 2 as mediator of macrophage responses in cardiovascular disease
Holger Winkels
Clinic III of Internal Medicine

 4:10 - 4:25 p.m.

BTLA in the pathogenesis of glomerulonephritis
Sebastian P Brähler
Kidney Research Center Cologne - Clinic II of Internal Medicine I CMMC - CAP 17

4:25 - 4:35 p.m.

Panel discussion with the speakers

4:35 - 4:50 p.m.

Digital Coffee Break

4:50 - 6:00 p.m.   

CMMC Lecture
Laudatio - Sabine Eming

Cytoprotective Signaling Pathways in Tissue Repair and Inflammatory Diseases
Sabine Werner
Institute for Molecular Health Sciences - ETH Zurich, CH