Riffelmacher, Thomas - assoc. RG

We research the metabolic regulation of T-cells and investigate how nutrition and metabolism control the various functions of the immune system. These connections are crucial for health because the metabolism of a single immune cell is closely linked to the metabolism of the entire body.

We recently demonstrated that different metabolic pathways in so-called “unconventional T cells” direct their function toward either pro-inflammatory and anti-tumor phenotypes or regulatory and reparative phenotypes.

A key focus of our work is the metabolically competitive tumor microenvironment and cardiovascular diseases characterized by dyslipidemia.

Prof. Thomas Riffelmacher: “By understanding how systemic nutrient status, tissue-specific metabolic signals, and cellular metabolic programs interact to regulate T cell functions, we aim to specifically modulate immune responses, optimize metabolic health, and develop new therapeutic approaches.”

For more information about Prof. Riffelmacher´s research and work, please go to ImmunoMet or visit his BlueSky Account. 

• CMMC Center for Molecular Medicine Cologne
• Donor Unrestricted T Cells Community (elected member)
• Bill and Melinda Gates Foundation