Schiavinato, Alvise - assoc. RG 71

We study the structure and assembly of collagen VI, in part at atomic resolution. The purpose is to understand pathomechanisms of collagen VI-dependent musculoskeletal diseases. This may allow future therapeutic approaches. We further study the release, cell binding, cellular uptake and effects of biologically active fragments of collagen VI, such as endotrophin. We want to understand the signaling functions of collagen VI and lay a better foundation for the use of collagen VI fragments as biomarkers for human disease.

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• Center for Molecular Medicine Cologne (CMMC)