Center for Molecular Medicine Cologne

Dr. med. Dr. nat. med. Deniz Hos - Curriculum Vitae

Education and professional career

2017: Co-Principal Investigator, B3 “Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency”, Center for Molecular Medicine Cologne (CMMC)
2016: European and German Board Exam in Ophthalmology
2015: Principle Investigator of Project 5 “Myeloid cell function in corneal hem- and lymphangiogenesis” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne
2014: Speaker, Young DOG (Residents of the German Ophthalmological Society)
2012-2016: PhD, Center for Molecular Medicine Cologne (CMMC), University of Cologne
2011: Resident physician and scientific assistant, Department of Ophthalmology, University Hospital of Cologne
2006-2010: Doctorate degree (Dr. med) (summa cum laude) at the University of Erlangen-Nuremberg
2006-2009: Diploma in Molecular Medicine, University of Erlangen-Nuremberg
2002-2010: Medical School at the University of Erlangen-Nuremberg, Approbation (licence to practice medicine)

Awards, distinctions and professional activities

2014: Research Award of the German Ophthalmological Society (Eye foundation)
2013: Dry Eye Research Award, Annual Meeting of the German Ophthalmological Society (DOG) 2013, Berlin, Germany
2010: Karl Giehrl Award 2011 for best medical dissertation, University of Erlangen-Nuremberg
2007: Research scholarship of the Interdisciplinary Center of Clinical Research, IZKF, University of Erlangen-Nuremberg
2007: Travel grant, GlaxoSmithKline GmbH, ARVO Annual Meeting 2007, Fort Lauderdale, USA

Selected publications

Bukowiecki A, Hos D, Cursiefen C, and Eming SA: Wound-healing studies in cornea and skin: parallels, differences and opportunities. Int J Mol Sci. 2017 18(6).

Hos D, Tuac O, Schaub F, Stanzel TP, Schrittenlocher S, Hellmich M, Bachmann BO, and Cursiefen C.: Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty: Retrospective Analysis of 1000 Consecutive Eyes. Ophthalmology. 2017 Apr;124(4):512-518.

Hos D, Dörrie J, Schaft N, Bock F, Notara M, Kruse FE, Krautwald S, Cursiefen C, and Bachmann BO: Blockade of CCR7 leads to decreased dendritic cell migration to draining lymph nodes and promotes graft survival in low-risk corneal transplantation.  Exp Eye Res. 2016 May;146:1-6.

Hos D, Bucher F, Regenfuss B, Dreisow ML, Bock F, Heindl LM, Eming SA, and Cursiefen C.: IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages. Am J Pathol. 2016 Jan;186(1):159-71.

Bock F, Onderka J, Braun G, Schneider AC, Hos D, Bi Y, Bachmann BO, and Cursiefen C: Identification of Novel Endogenous Anti(lymph)angiogenic Factors in the Aqueous Humor. Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6554-6560.

Lee HS, Hos D, Blanco T, Bock F, Reyes NJ, Mathew R, Cursiefen C, Dana R, and Saban DR:  Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease. Invest Ophthalmol Vis Sci. 2015 May;56(5):3140-8.

Hos D, Schlereth SL, Bock F, Heindl LM, and Cursiefen C:  Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: what can we learn from the eye? Semin Cell Dev Biol. 2015 Feb;38:117-30.

Hos D and Cursiefen C: Lymphatic vessels in the development of tissue and organ rejection. Adv Anat Embryol Cell Biol. 2014;214:119-41.

Koch KR, Refaian N, Hos D, Schlereth SL, Bosch JJ, Cursiefen C, and Heindl LM: Autocrine impact of VEGF-A on uveal melanoma cells. Invest Ophthalmol Vis Sci. 2014 Apr 25;55(4):2697-704.

Bucher F, Bi Y, Gehlsen U, Hos D, Cursiefen C, and Bock F:  Regression of mature lymphatic vessels in the cornea by photodynamic therapy. Br J Ophthalmol. 2014 Mar;98(3):391-5.

Hoffmann SA, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, and Reiprich S: Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.  Development. 2014 Jan;141(1):39-50.

Hos D, Koch KR, Bucher F, Bock F, Cursiefen C, and Heindl LM: Serum eyedrops antagonize the anti(lymph)angiogenic effects of bevacizumab in vitro and in vivo.  Invest Ophthalmol Vis Sci. 2013 Sep 11;54(9):6133-42.

Bock F, Maruyama K, Regenfuss B, Hos D, Steven P, Heindl LM, and Cursiefen C.: Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases.  Prog Retin Eye Res. 2013 May;34:89-124.

Hos D, Regenfuss B, Bock F, Onderka J, and Cursiefen C.: Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis. Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5778-85.

Hos D, Saban DR, Bock F, Regenfuss B, Onderka J, Masli S, and Cursiefen C: Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. Arch Ophthalmol. 2011 Apr;129(4):445-52.

Regenfuss B, Onderka J, Bock F, Hos D, Maruyama K, and Cursiefen C: Genetic heterogeneity of lymphangiogenesis in different mouse strains. Am J Pathol. 2010 Jul;177(1):501-10.

Dietrich T, Bock F, Yuen D, Hos D, Bachmann BO, Zahn G, Wiegand S, Chen L, and Cursiefen C: Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after  transplantation. J Immunol. 2010 Jan 15;184(2):535-9.

Bachmann BO, Luetjen-Drecoll E, Bock F, Wiegand SJ, Hos D, Dana R, Kruse FE, and Cursiefen C: Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation. Br J Ophthalmol. 2009 Aug;93(8):1075-80.

Hos D, Bachmann B, Bock F, Onderka J, and Cursiefen C:  Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis. Exp Eye Res. 2008 Nov;87(5):427-32.

Hos D, Bock F, Dietrich T, Onderka J, Kruse FE, Thierauch KH, and Cursiefen C: Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation. Invest Ophthalmol Vis Sci. 2008 May;49(5):1836-42.