Program

Session II:
Phase separation in transcriptional regulation

Chairs: Axel Hillmer (Inst. of Pathology) - Andreas Beyer (CECAD)

9.00 - 9.30 a.m.

Phase separation and transcriptional control
Richard A Young
Whitehead Institute for Biomedical Research, Dept. of Biology, Massachusetts Institute of Technology - Cambridge, US

9.30 - 10.00 a.m.

A solid state conceptualization of information transfer from gene to message to protein
Stephen L McKnight
Biochemistry Department, UT Southwestern Medical Center - Dallas, US

10.00 - 10.30 a.m.

Is chromatin just a phase?
Gary H Karpen
Lawrence Berkeley National Lab, Dept. of Genome Biology, University of California, Berkeley - Berkeley , US

10.30 - 11.00 a.m.

Coffee Break

Session III:
Transcriptional and posttranscriptional control

Chairs: Tim Hucho (Dept. of Anaesthesiology & Intensive Care Medicine) - Argyris Papantonis (CMMC)

11.00 - 11.30 a.m.

Epigenetics: one genome, multiple phenotypes
Danny Reinberg
Howard Hughes Medical Institute, NYU Langone School of Medicine - New York, US

11.30 - 12.00 p.m.

Epigenetic regulation by histone acetylation
Asifa Akhtar
Max Planck Institute of Immunobiology and Epigenetics - Freiburg, DE

12.00 - 12.30 p.m.

Transcription and remodeling produce asymmetrically unwrapped nucleosomes
Steven Henikoff
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center - Seattle, US

12.30 - 2.00 p.m.

Lunch Break (soup and sandwiches for all participants at the venuue

Chairs: Achim Tresch (Institute of Med. Statistics & Computational Biology) - Peter Tessarz (MPI Age)

2.00 - 2.30 p.m.

Principles of nuclear organization in developmentally controlled gene expression
Susan M Gasser
Friedrich Miescher Institute for Biomedical Research - Basel, CH

2.30 - 3.00 p.m

RNA methylation in gene expression regulation
Chuan He
Dept. of Chemistry and Institute for Biophysical Dynamics, The University of Chicago - Chicago, US

3.00 - 3.30 p.m

Epigenetic mechanisms in early mammalian development
Maria Elena Torres-Padilla
Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München - Munich, DE

3.30 - 3.50 p.m.

Coffee Break

3.50 - 4.00 p.m.

Announcement of the "Klenk Symposium Poster Award"

Session IV - Part 1:
Epigenetic strategies for therapeutic intervention

Chairs: Margarete Odenthal (Inst. of Pathology) - Martin Sos (Inst. of Pathology)

4.00 - 4.30 p.m.

Awakening endogenous retroviruses for cancer therapy
Peter A Jones
Van Andel Research Institute  - Grand Rapids, US

4.30 - 5.00 p.m.

Uncovering the role of Sirtuin ADPribosylation: The link between SirT7, macroH2A and glucose starvation
Alejandro Vaquero
IDIBELL - Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - Barcelona, ES

5.00 - 5.30 p.m.

Transforming chromatin: oncogenic activity of mutant histone H3
Suzanne J Baker
Developmental Neurobiology, St. Jude Children's Research Hospital  - Memphis, US

5.30 - 6.00 p.m.

Coffee Break

6.00 - 7.00 p.m.

Ernst Klenk Lecture

Laudation: Reinhard Büttner

The novel histone methyltransferase KMT9 writes the histone mark H4K12me1 and controls castration-resistant prostate cancer
Roland Schüle
Dept. of Urology and Center for Clinical Research, Medical Center University of Freiburg - Freiburg, DE

12.50 p.m.

Welcome Address

Thomas Krieg         Dean - Medical Faculty, University of Cologne

Thomas Benzing    Chair - Center for Molecular Medicine Cologne

Roland Schüle - Yang Shi - Michal-Ruth Schweiger - Reinhard Büttner
Scientific coordinators - Ernst Klenk Symposium 2018

Session I:
Nuclear architecture and chromatin remodeling

Chairs: Argyris Papantonis (CMMC) - Aleksandra Trifunovic (CECAD)

1.00 - 1.30 p.m.

Mechanism of chromatin regulators: Lessons from the genomics of human disease and new methods
Gerald R Crabtree
Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford University - Stanford, US

1.30 - 2.00 p.m.

Physics of chromosome folding
Leonid A Mirny
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology - Cambridge, US

2.00 - 2.30 p.m.

Dynamics of chromosomal differentiation using single cell epigenomics
Amos Tanay
Epigenomics and Evolution, The Weizmann Institute - Rehovot, IL

2.30 - 3.00 p.m.

Coffee Break

Chairs: Linda Partidge (MPI Age) - Jan Riemer (Inst. for Biochemistry)

3.00 - 3.30 p.m.

Genome architecture in specific neuronal cells
Ana Pombo
Max Delbrück Center for Molecular Medicine and Institute for Medical Systems Biology, Humboldt University Berlin - Berlin, DE

3.30 - 4.00 p.m.

3D genome structures of single diploid human cells
Xiaoliang Sunney Xie
Dept. of Chemistry and Chemical Biology, Harvard University - Cambridge, US

4.00 - 4.30 p.m.

Mechanisms of chromatin transcription
Patrick Cramer
Max Planck Institute for Biophysical Chemistry - Göttingen, DE

4.30 - 5.00 p.m.

Coffee Break

5.00 - 6.00 p.m.

Ernst Klenk Lecture

Laudation: Michal-Ruth Schweiger

Chromatin modifications, tumor cell immunogenicity and checkpoint blockade
Yang Shi
Harvard Medical School, Boston's Children Hospital – Boston, US

6.00 - 8.30 p.m.

Poster Award
The Klenk Poster Award 2018 of the Center for Molecular Medicine Cologne (CMMC) will be awarded to the presenting first author of the three most outstanding poster contributions. The awardees are invited to give a short presentation (10 min.) during the last session on Saturday, Oct. 06, 2018 of the Klenk Symposium 2018.

Session IV - Part 2:
Epigenetic strategies for therapeutic intervention

Chairs: Christian Reinhardt (Dept. I for Internal Medicine) and Reinhard Büttner (Inst. of Pathology)

9.00 - 9.30 a.m.

Transcriptional vulnerabilities of cancer cells
Christopher R Vakoc
Cold Spring Harbor Laboratory - Cold Spring Harbor, US

9.30 - 10.00 a.m.

Targeting of acetyl-lysine reader domains by small molecules
Stefan Knapp
Institut für Pharmazeutische Chemie, Goethe-Universität - Frankfurt, DE

10.00 - 10.30 a.m.

Short presentation
by the three poster awardees (3 x 10 min. short talk)

10.30 - 11.00 a.m.

Coffee Break

Session V:
Regulation of development and disease

Chairs: Martin Peifer (Department of Translational Genomics) and Matthias Fischer (Dept. for Exp. Pediatric Oncology)

11.00 - 11.30 a.m.

Mutation induced changes
Stefan Mundlos
Institut für Medizinische Genetik, Charité, Universitätsmedizin Berlin - Berlin, DE

11.30 - 12.00 p.m.

Long range gene regulation in mammalian development and disease
Denis Duboule
School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL) - Lausanne, CH

12.00 - 12.30 p.m.

TET methylcytosine oxidases, immune responses and cancer
Anjana Rao
Department of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology - La Jolla, US

12.30 - 1.30 p.m.

lunch break (sandwiches for all participants at the venue)

Chairs: Michal R Schweiger (Translational Epigenetics and Tumor Genetics) and Walter Doerfler (Inst. for Genetics)

1.30 - 2.00 p.m.

The role of DNA methylation in development and disease
Alexander Meissner
Max Planck Institute for Molecular Genetics - Berlin, DE

2.00 - 2.30 p.m.

Single cell epigenome landscape of development and ageing
Wolf Reik
Babraham Institute - Cambridge, US

2.30 - 3.00 p.m.

Evolution and cellular origin of the CLL methylome
Christoph Plass
German Cancer Research Center (DKFZ) - Heidelberg, DE

3.00 - 3.15 p.m.

Summary, open questions, concluding remarks
Roland Schüle - Yang Shi - Ruth-Michal Schweiger - Reinhard Büttner

General Information

Registration

Childcare is provided by Spielland, University Hospital Cologne.
Please contact us for further information: klenk-symposium[at]uni-koeln.de.

For directions please visit:
http://www.uk-koeln.de/fileadmin/user_upload/Lageplaene/lageplan_uniklinik_koeln.pdf

For a site map please visit:
http://www.cmmc-uni-koeln.de/de/events/ernst-klenk-symposium/ernst-klenk-symposium-2018/venue/