Center for Molecular Medicine Cologne
12.45 p.m.

Welcome Address

Axel Freimuth - Rector of the  University of Cologne

Thomas Krieg - Vice President of the ´Nationale Akademie der Wissenschaften (Leopoldina)

Thomas Benzing - Chair - Center for Molecular Medicine Cologne, University of Cologne

Session I:
Stem Cell Biology and Regenerative Medicine

Chairs: Claus Cursiefen and Carien Niessen (Cologne, DE)

1.00 - 1.10 p.m.

of the research field

1.10 - 1.40 p.m.

SARS-CoV-2 genomic integration, expression and cell tropism
Rudolph Jaenisch
Massachusetts Institute of Technology - Cambridge, US

1.40 - 2.10 p.m.

Mechanisms of mammalian cell fate decisions
Thomas Graf
Centre for Genomic Regulation (CRG) - Barcelona, ES

2.10 - 2.40 p.m.

Proteostasis of aging and stem cells
David Vilchez
CECAD - Cologne Excellence Cluster Diseases - Cologne, DE

2.40 - 3.10 p.m.

Hybrid Coffee Break

3.10 - 3.40 p.m.

Single factor induction of divergent cell fates
Konrad Hochedlinger

Massachusetts General Hospital, Harvard Dept. of Stem Cell and Regenerative Biology and Howard Hughes Medical Institute - Boston, US

3.40 - 4.10 p.m.

From melanoma to Parkinson’s disease – applications of human pluripotent stem cells
Lorenz Studer
The Center for Stem Cell Biology, Developmental Biology Program, Memorial Sloan-Kettering Institute for Cancer Research - New York, US

4.10 - 4.40 p.m.

Advanced genetic engineering of hematopoiesis to treat inherited diseases and cancer
Luigi Naldini
San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University - Milan, IT

4.40 - 5.00 p.m.

Hybrid Coffee Break

5.00 - 5.30 p.m.

Introduction - Thomas Krieg (Cologne, DE)

The Center for Molecular Medicine Cologne: the last 25 years and the future
Franz Hofmann
Institute for Pharmacology and Toxicology, Technical University Munich - Munich, DE

5:30 - 5:45 p.m.

Hybrid Coffee Break and "Get ready for the CMMC Poster Session"

Welcome to the CMMC Poster Session

Of note: The CMMC Poster Session has now been integrated directly into the CMMC Symposium Program.

August 27, 2021: Deadline extended for the submission of the poster abstracts - for further information please visit

5.45 - 6.00 p.m.

Welcome Address - Michal-Ruth Schweiger (Cologne, DE)

6.00 - 7.30 p.m.

Presentations of Posters No. 01 - 60
Poster Session MAP 1 and Poster Session MAP 2

7.30 - 9.00 p.m.

Presentations of Posters No. 61 - 120
Poster Session MAP 3 and Poster Session MAP 4

9.00 - 9.10 p.m.

Concluding Remarks - Michal-Ruth Schweiger (Cologne)


Session II:
Molecular Oncology and Genomic Medicine

Chairs: Reinhard Büttner and Michal-Ruth Schweiger (Cologne, DE)

8.30 - 8.40 a.m.

of the research field

8.40 - 9.10 a.m.

Precision oncology: experiences and challenges in translating genomic information into clinical decisions
Peter Lichter

German Cancer Research Center, DKFZ - Heidelberg, DE

9.10 - 9.40 a.m.

Mutational footprints of cancer therapies
Núria López-Bigas

Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology - Barcelona, ES

9.40 - 10.10 a.m.

The Human Cell Atlas: mapping the body one cell at a time
Sarah Teichmann
Cellular Genetics, Wellcome Sanger Institute - Hinxton, GB

10.10 - 10.30 a.m.

Hybrid Coffee Break

10.30 - 11.00 a.m.

Darwinian and Non-Darwinian Evolution in Cancer
Marco Gerlinger
Institute of Cancer Research - London, GB

11.00 - 11.30 a.m.

Mapping childhood brain tumors onto normal cerebellar development
Stefan Pfister

Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg - Heidelberg, DE

11.30 - 12.30 a.m.

Hybrid Lunch Break with hybrid scientifc networking

Session III:
Precision Medicine in Cancer Treatment

Chairs: Michal-Ruth Schweiger and Martin Sos - Cologne, DE

12.30 - 12.40 p.m.

of the research field

12.40 - 1.10 p.m.

The role of stress signaling in cancer and cancer treatment
Michael B Yaffe

Massachusetts Institute of Technology, Center for Precision Cancer Medicine and Koch Institute for Integrative Cancer Research - Cambridge, US

1.10 - 1.40 p.m.

Exploiting synthetic lethality in the treatment of cancer
Chris J Lord

Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research - London, GB

1.40 - 2.10 p.m.

The making of diffuse large B cell lymphoma
Laura Pasqualucci
Institute for Cancer Genetics, Columbia University - New York, US

2.10 - 2.30 p.m.

Hybrid Coffee Break

2.30 - 3.00 p.m.

Lymphoma epigenetics
Ari M Melnick

Division of Hematology & Medical Oncology, Sackler Center for Biomedical and Physical Sciences, Weill Cornell Medicine - New York, US

3.00 - 3.30 p.m.

10 years checkpoint blockade - what have we learned?
Dirk Schadendorf
Dept. of Dermatology, University Hospital Essen, Univ. Duisburg - Essen, DE

3.30 - 3.40 p.m.

Announcement of the three CMMC Poster Prize Winners
Michal-Ruth Schweiger (Cologne)

3.40 - 4.00 p.m.

Hybrid Coffee Break

Session IV:
Infectious Diseases

Chairs: Martin Krönke and Jan Rybniker (Cologne, DE)

4.00 - 4.10 p.m.

Ralf Bartenschlager

Dept. of Infectious Diseases, University Hospital Heidelberg - Heidelberg, DE

4.10 - 4.40 p.m

Respiratory virus pathogenicity in high-risk groups
Gülsah Gabriel

Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology - Hamburg, DE

4.40 - 5.10 p.m

Antibody-mediated neutralization of SARS-CoV-2
Florian Klein

Institute for Virology, University of Cologne - Cologne DE

5.10 - 5.30 p.m.

Hybrid Coffee Break

5.30 - 6.00 p.m.

Towards a curative therapy for Hepatitis B and D co-infected patients
Stephan Urban

Department of Infectious Diseases, University Hospital Heidelberg - Heidelberg, DE

6.00 - 6.30 p.m.

Vaccines and monoclonals to regain our freedom
Rino Rappuoli

Chief Scientist und Head of External Research and Development (R&D) at GlaxoSmithKline Vaccines - Siena, IT

6.30 - 7.00 p.m.

Survival strategies of malaria parasites in the dry season
Silvia Portugal

Max Planck Institute for Infection Biology - Berlin, DE

Session V:
Neuroplasticity and Neurodegeneration

Chairs: Dirk Isbrandt and Tatiana Korotkova (Cologne, DE)

9.00 - 9.10 a.m.

of the research field

9.10 - 9.40 a.m.

Dynamic control of presynaptic function in health and disease
Nils Brose

Dept. of Molecular Neurobiology, Max Planck Institute for Exp. Medicine - Goettingen, DE

9.40 - 10.10 a.m.

Neuronal correlates of emotion states in mice
Nadine Gogolla
Max Planck Institute of Neurobiology - Martinsried, DE

10.10 - 10.40 a.m.

Tau toxicity at the synapse
Patrik Verstreken
VIB-KU Leuven Center for Brain & Disease Research - Leuven, BE

10.40 - 11.00 a.m.

Hybrid Coffee Break

11.00 - 11.30 a.m.

Negative feedback control of neuronal activity by microglia
Anne Schaefer
Friedman Brain Inst. and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai - New York, US

11.30 - 12.00 p.m.

Mechanisms for fast dopamine signaling
Pascal S Kaeser
Department of Neurobiology, Harvard Medical School - Boston, US

12.00 - 12.15 p.m.

Awarding of the CMMC Poster Prizes and short talks (3x 5 min.) given by the awardees
Michal-Ruth Schweiger (Cologne)

12.15 - 1.00 p.m.

Hybrid Lunch Break with hybrid scientific networking (lunch included for all participants at the venue)

Session VI:
Metabolism and Aging

Chairs: Sabine Eming and Aleksandra Trifunovic (Cologne, DE)

1.00 - 1.10 p.m.

of the research field

1.10 - 1.40 p.m.

CNS-dependent control of metabolism
Jens C Bruening
Max Planck Institute for Metabolism Research, CEDPM and CECAD Cologne - Cologne, DE

1.40 - 2.10 p.m.

Hormone sensing in astrocytes for the control of systemic metabolism
Cristina García Cáceres

Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute for Diabetes and Obesity - Neuherberg, DE

2.10 - 2.30 p.m.

Hybrid Coffee Break

2.30 - 3.00 p.m.

Reversing the decline in physical activity with age
Lora Heisler
The Rowett Institute, University of Aberdeen - Aberdeen, GB

3.00 - 3.30 p.m.

Mechanisms of stem cell aging and rejuvenation
Anne Brunet
Dept. of Genetics, Stanford University School of Medicine - Stanford, US

3.30 - 4.00 p.m.

The surprising role of glia in the regulation of metabolism and aging
Andrew Dillin

Dept. of Molecular and Cell Biology, University of California Berkeley - Berkeley, US

4.00 - 4.10 p.m.

Summary, open questions, closing remarks and leave-taking


General Information

Registration and participation in the CMMC Symposium "25 Years of Progress in Molecular Medicine" is free of charge!
Please register here

Considering the Covid-19 developments as well as the hygiene measures of the University Hospital Cologne, we regret to inform you that only a limited  number of participants will be able to attend the venue in person. We reserved the limited "seats" for the guest speakers and the chairs of the sessions. The few remaining seats will be allocated to "local" participants - strict "2 G regulation) .

We very well know nothing beats a face to face meeting but while we cannot meet in person, we are excited to welcome you as a digital participant at the CMMC Symposium 2021 including the CMMC Poster Session. We have put a lot of effort into making the digital CMMC Symposium as interactive and exciting as possible for all.

If you have further questions, please do not hesitate to contact me or the members of the CMMC Office Team by e-mail:

We are looking forward to welcoming you as virtual participant in the CMMC Symposium 2021 and wish you a stimulating and enjoyable conference with inspiring presentations and fruitful discussions.

With best regards

Debora Grosskopf-Kroiher

For our guest speakers - directions and site map

Program - CMMC Symposium 2021

We gratefully acknowledge support by

Poster - CMMC Symposium 2021

Gerhard Richter

We are delighted, that the Poster 25 Years of Molecular Medicine shows the abstract artwork "Colour-Charts - 1024 Colours - 1974 / Werkverzeichnis 358-1" of Gerhard Richter. This is an outstanding honour for us.
With a career spanning nearly six decades, Gerhard Richter is widely considered one of the greatest artists of our time. To explore the artist's work, please visit:

Contacts for general information

The meeting is open and no registration or attendance fee is required. Participation is free of charge - free registration is required.

For questions releated to your registration please contact Bettina Kranz - zmmk-office[at]