Center for Molecular Medicine Cologne

1st Cologne Symposium on missing links in HPV-biology: Focus on head & neck and skin cancer
May 17 - 18, 2019


11.30 a.m. - 12.50 p.m.

Reception with Welcome-Lunch

12.50 p.m.

Welcome Address

Thomas Krieg        
Medical Faculty, University of Cologne

Thomas Benzing
Center for Molecular Medicine Cologne, University of Cologne

Opening Remarks

Baki Akgül - Jens Peter Klussmann

Session 1: Epidemiology

Chair: Baki Akgül - Institute for Virology, University of Cologne - Cologne, DE

1.00 - 1.30 p.m.

Association of beta-HPV and skin cancer
Herbert Pfister
Institute for Virology, University of Cologne - Cologne, DE

1.30 - 2.00 p.m.

Detection and natural history of HPV infection of oral cavity and tonsils
Ulrike Wieland
Institute for Virology and National Reference Center for Papilloma- and Polyomaviruses, University Hospital of Cologne - Cologne, DE

2.00 - 2.30 p.m.

Immunological control of HPV-driven oropharyngeal cancer
Sjoerd H van der Burg

Dept. of Clinical Oncology, Leiden University Medical Center - Leiden, NL

2.30 - 3.00 p.m.

Coffee Break

Session 2: Immunology

Chair: Jens Peter Klussmann -Dept. of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne - Cologne, DE

3.00 - 3.30 p.m.

What happens between seroconversion and development of HPV positive oropharyngeal cancer?
Tim Waterboer

Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ) - Heidelberg, DE

3.30 - 4.00 p.m.

Homeostasis and adaptation of epithelial transition zone niche: the hot spots of infection and cancer
Cindrilla Chumduri

Dept. of Molecular Biology, Max Planck Institute for InfectionBiology - Berlin, DE

4.00 - 4.30 p.m.

Tumor microenvironment as biomarker of HPV positive oropharyngeal cancer?
Anders Näsman

Dept. of Oncology-Pathology, Karolinska Institute - Stockholm, SE

4.30 - 5.00 p.m.

Coffee Break

Session 3: Genomics

Chair: Alexander Quaas - Institute for Pathology, University Hospital Cologne - Cologne, DE

5.00 - 5.30 p.m.

Mutation signature in epithelial cancer
Julie George

Dept. of Translational Genomics, University Hospital Cologne - Cologne, DE

5.30 - 6.00 p.m.

Causes and consequences of HPV integration in oropharyngeal cancer
Ernst-Jan M Speel

Dept. of Pathology, Maastricht University Medical Center - Maastricht, NL

6.00 - 6.30 p.m.

Genomic signature of HPV positive oropharyngeal cancer
Ruud H Brakenhoff

Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology-Head and Neck Surgery, Cancer Center Amsterdam - Amsterdam, NL

6.30 - 9.00 p.m.

Invitation of the Get-Together "Missing Link in HPV Biology" at the venue

free finger food and drinks

Session 4: Stem cell and differentiation

Chair: Paola Zigrino - Dept. of Dermatology, University Hospital Cologne - Cologne, DE

9.00 - 9.30 a.m.

Cancer stem cells in HPV-related cancer
Michael Herfs
Laboratory of Exp. Pathology, GIGA Cancer, University of Liege - Liege, BE

9.30 - 10.00 a.m.

Role of skin stem cells in beta-HPV carcinogenesis
Girish Patel
European Cancer Stem Cell Research Institute, School of Bioscience, Cardiff University - Cardiff, GB

10.00 - 10.15 a.m.

Coffee Break

10.15 - 10.45 a.m.

Mastomys coucha as animal model to understand cutaneous HPV carcinogenesis
Frank Rösl

Division of Viral Transformation Mechanisms, German Cancer Research - Heidelberg, DE

10.45 - 11.15 a.m.

HPV oncoproteins manipulate epithelial differentiation
Elizabeth White

Dept. of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine - Philadelphia, US

11.15 - 11.30 a.m.

Coffee Break

Session 5: Carcinogenesis

Chair: Gertrud Steger - Institute for Virology, University Hospital Cologne - Cologne, DE

11.30 - 12.00 a.m.

Metabolic stress in HPV positive oropharyngeal cancer
Christian Hübbers

Jean-Uhrmacher-Institute for Otorhinolaryngological Research, University of Cologne - Cologne, DE

12.00 - 12.30 p.m.

Interference of HPV with DNA damage and repair pathway
Nicholas N Wallace

Division of Biology, Kansas State University- Manhattan, US

12.30 - 1.00 p.m.

Cutaneous papillomaviruses: from mice to men
Karl Münger

Dept. of Developmental Molecular and Chemical Biology, Tufts University School of Medicine - Boston, US

1.00 - 1.45 p.m.

Lunch Break

Session 6: Epigenetics

Chair: Michal-Ruth Schweiger - Laboratory - Functional Epigenome, University of Cologne - Cologne, DE

1.45 - 2.15 p.m.

Epigenetic and autophagic changes in skin cancer
Daniele Bergamaschi

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University - London, GB

2.15 - 2.45 p.m.

Methylation of the HPV genome
Magnus von Knebel Doeberitz

Dept. of Applied Tumor Biology, Institute of Pathology, University Hospital of Heidelberg and German Cancer Research Center - Heidelberg, DE

2.45 - 3.15 p.m.

The methylome and miRNA profile in HPV positive cancer
Jochen Hess

Dept. of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Heidelberg - Heidelberg, DE

3.15 - 3.30 p.m.

Concluding remarks

Baki Akgüland Jens Peter Klussmann
University of Cologne and University Hospital of Cologne

We gratefully acknowledge support by

Certified with 24 CME Credits

by the Nordrheinische Akademie für aerztliche Fort- und Weiterbildung, Duesseldorf (Germany).