Research Area C

Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Alcazar, Miguel A Alejandre
Netrin-1 as a new target to treat chronic lung disease: Identification of agonists and antagonists by artificial intelligence
Antczak, Philipp - assoc. JRG 06 and CAP 20
Understanding the molecular basis of stress, longevity, and aging
Benzing, Thomas - C 01
Pressure-dependent proteostasis regulation in podocytes at the kidney filtration barrier and the pathogenesis of albuminuria
Beyer, Andreas | Hänsel-Hertsch, Robert - C 02
Detecting transcriptional mistakes of RNA Polymerase-II at the single-cell level
Brüning, Jens C - C 03
Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity
Clahsen, Thomas - assoc. RG 05
Identification of novel endogenous modulators of developmental and inflammatory lymphangiogenesis by analyzing mouse strain-specific differences
Eming, Sabine | Fabri, Mario - C 04
Unlocking tissue protective and regenerative functions of myeloid cells by metabolic reprograming
Fischer, Dietmar - assoc. RG 43
Validation of a new natural class of compounds for therapeutic use in nerve regeneration
Gehring, Niels - C 05
Function of nonsense-mediated mRNA decay in brain development and neurological disease
Hammerschmidt, Matthias - C 06
Novel pathomechanisms of spine abnormalities and intervertebral disc degeneration caused by mutations in the fatty acid synthase gene
Haensel-Hertsch, Robert - JRG 10
(Epi)Genome structure and stability
Hoppe, Thorsten - C 07
Understanding the pathomechanism of spinocerebellar ataxia caused by inherited mutations in the ubiquitin ligase CHIP
Isbrandt, Dirk - assoc. RG 39
Krieg, Thomas - SRG 02
The role of activated fibroblasts in fibrosis – scleroderma as a model disease
Kononenko, Natalia - C 08
Dissecting the role of Alzheimer’s disease-associated endocytosis risk factors in regulating cell cycle events in neuronal cells
Korotkova, Tatiana | Schaefer, Anne - C 09
Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology
Krüger, Marcus - assoc. RG 40
Lemberg, Marius | Schiavinato, Alvise | Nüchel, Julian - C 10
Triaging of secretory cargo by interplay of TANGO1 and ERAD-R
Liebau, Max C | Schermer, Bernhard C 11
Understanding the mechanisms underlying early kidney failure in ARPKD
Maleki, Hajar - assoc. JRG 08
Functional Bio-inspired Porous Materials
Müller, Roman-Ulrich - assoc. RG 13
Hypoxia-signaling at the crossroads of cellular stress resistance and tumorigenesis
Niessen, Carien M | Hanßen, Ruth - C 12
Skin insulin resistance in type II diabetes and its associated diseases
Pfannkuche, Kurt P - assoc. RG 17
Cardiac tissue engineering
Pla-Martín, David - CAP 25
Modulate mitochondrial quality control to decelerate disease progression
Rosenkranz, Stephan | Vantler, Marius - C 13
Role of TNF-mediated inflammatory signaling in heart failure with preserved ejection fraction (HFpEF) and associated pulmonary hypertension (PH)
Rugarli, Elena I - C 14
Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways
Schwarz, Guenter - C 15
Development of treatments for molybdenum cofactor and sulfite oxidase deficiency
Sengle, Gerhard - assoc. RG 21
New molecular mechanisms of fibrosis
Stoffel, Wilhelm - SRG 01
Antagonistic pleiotropy of the Δ6-fatty acid desaturase (fads2) gene in disease and senescence. ω3- and ω6-Polyunsaturated fatty acids in Δ6-fatty acid desaturase (fads2-/-) deficiency
Trentini Schmidt, Débora B - assoc. JRG 05
Protein quality control and stress response
Trifunovic, Aleksandra | Szczepanowska, Karolina - C 15
Manipulation of CLPP protease to complement mitochondrial respiratory deficiency
Vilchez, David - C 16
Correction of alterations in the ubiquitinated proteome to prevent age-related neurodegenerative diseases
Vogt, Johannes | Kepser, Lara-Jane - C 17
Bioactive lipid signaling in adult neurogenesis and metabolic modulation
Wirth, Brunhilde | Piano, Valentina - C 18
Vesicular trafficking and axonal local translation in health and motor neuron disease

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