Center for Molecular Medicine Cologne

Individual Project Funding Program - Funding Period 01/2023 - 12/2025

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

A 01 - The mitotic surveillance pathway in stem cells
Hisham Bazzi - Clinic of Dermatology and Venereology

A 02 - Role of synaptic hijacking in SCLC brain metastatic growth
Matteo Bergami1 | Elisa Motori2 - 1CECAD – Med. Faculty | 2Institute of Biochemistry

A 03 - Systematic mapping of the p62-KEAP1-NRF2 axis and co-regulated pathways across human cancers
Reinhard Büttner | Evangelos Kondylis - Institute of Pathology

A 04 - Elucidating the mechanisms of spontaneous regression and differentiation in neuroblastoma using genetically engineered mouse models
Matthias Fischer - Clinic for Pediatric and Adolescent Medicine

A 05 - The dialogue of CLL cells with the tumor microenvironment as a mediator of treatment resistance against targeted inhibitor combinations
Lukas Frenzel | Michael Hallek - Clinic I of Internal Medicine

A 06- Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma
Axel Hillmer | Reinhard Büttner - Institute of Pathology

A 07 - Targeting the Necroptosis Pathway in Pancreatic Cancer
Silvia von Karstedt
Dept. of Translational Genomics and CECAD

A 08 - Engineering mRNA translation specialization modules to ameliorate pathological cardiac hypertrophy: from pathomechanisms to clinical targets, and off-the-shelf therapeutic strategies
Leo Kurian - Institute for Neurophysiology and CMMC

A 09 - Understanding the multifaceted regulation of T cell immunity in B cell lymphoma for improved immunotherapy
Phuong-Hien Nguyen | Renata Stripecke2 | Alessandro Annibaldi3
1Clinic I for Internal Medicine I 2Dept. for Transl. Immuno-Oncology Cancer Center Cologne Essen | 3CMMC

A 10 - Bypassing hotspot mutated p53
Björn Schumacher - Institute for Genome Stability in Aging and Disease and CECAD – Med. Faculty

A 11 - The crosstalk between marginal zone B cells and female hormonal state in the development of benign liver cancer
F Thomas Wunderlich - Clinic for Endocrinology, Diabetology and Preventive Medicine


Research Area B: Principles of immunity, inflammation and infection

B 01 - Inflammatory signaling in the PDSS2-model of metabolic podocyte damage – from mouse models to human biopsy analysis
Paul Brinkkötter | Sebastian Brähler - Clinic II of Internal Medicine

B 02 - Role of gut microbiota on the onset of sarcopenia
Filipe Cabreiro | Mauro Corrado | Francesca Solagna - CECAD – Math.-Nat. Faculty

B 03 - Epigenetic-metabolic crosstalk in the development of T cell immunological memory
Mauro Corrado - CECAD – Math.-Nat. Faculty

B 04 - Targeting the osmosensitive transcription factor NFAT5 in acute and chronic corneal edema
Claus Cursiefen | Karina Hadrian | Deniz Hos - Clinic of General Ophthalmology

B 05 - Endothelial cells and pericytes in cutaneous leishmaniasis
Jonathan Jantsch - Institute for Medical Microbiology, Immunology and Hygiene

B 06 - Role of IAPs in TNF-induced vasculature alteration and their therapeutic value in inflammatory diseases
Hamid Kashkar - Institute for Molecular Immunology and CECAD

B 07 - Retinal microglia and their immunological effects in AAV-based ocular gene therapy
Thomas Langmann | Anne Wolf - Clinic of General Ophthalmology

B 08 - Correlating biofilm structure with antibiotic tolerance
Berenike Maier1 | Paul Higgins2 - 1Inst. for Biological Physics – Math.-Nat. Faculty | 2Inst. for Medical Microbiology, Immunology and Hygiene

B 09 - Role of autophagy in the regulation of ZBP1-mediated cell death and inflammation
Manolis Pasparakis - Institute for Genetics and CECAD – Math.-Nat. Faculty

B 10 - Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination
Jan Rybniker | Sebastian Theobald - Clinic I for Internal Medicine

B 11 - Role of mitochondria in the regulation of innate immunity responses
Aleksandra Trifunovic - Institute for Mitochondrial Diseases and Ageing and CECAD – Med. Faculty

B 12 - Olfr2-mediated macrophage activation in obesity induced endothelial dysfunction
Holger Winkels | Martin Mollenhauer - Clinic III for Internal Medicine


Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration

C 01 - Pressure-dependent proteostasis regulation in podocytes at the kidney filtration barrier and the pathogenesis of albuminuria
Thomas Benzing - Clinic II of Internal Medicine

C 02 - Detecting transcriptional mistakes of RNA Polymerase-II at the single-cell level
Andreas Beyer1 | Robert Hänsel-Hertsch2 - 1CECAD – Med. and Math.-Nat. Faculty| 2CMMC

C 03 - Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity
Jens C Brüning - Clinic for Endocrinology, Diabetology and Preventive Medicine

C 04 - Unlocking tissue protective and regenerative functions of myeloid cells by metabolic reprogramming
Sabine Eming | Mario Fabri - Clinic of Dermatology and Venereology

C 05 - Function of nonsense-mediated mRNA decay in brain development and neurological disease
Niels Gehring - Institute for Genetics – Math.-Nat. Faculty

C 06 - Novel pathomechanisms of spine abnormalities and intervertebral disc degeneration caused by mutations in the fatty acid synthase gene
Matthias Hammerschmidt - Institute of Zoology – Math.-Nat. Faculty

C 07 - Understanding the pathomechanism of spinocerebellar ataxia caused by inherited mutations in the ubiquitin ligase CHIP
Thorsten Hoppe - Institute for Genetics and CECAD – Math.-Nat. Faculty

C 08 - Dissecting the role of Alzheimer’s disease-associated endocytosis risk factors in regulating cell cycle events in neuronal cells
Natalia Kononenko - Institute for Physiology and Pathophysiology

C 09 - Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology
Tatiana Korotkova1 | Anne Schäfer2 - 1Institute for Veg. Physiology | 2MPI for Biology of Ageing

C 10 - Triaging of secretory cargo by interplay of TANGO1 and ERAD-R
Marius Lemberg1 | Alvise Schiavinato2 | Julian Nüchel3
1Center for Biochemistry | 2Clinic for Pediatric and Adolescent Medicine | 3MPI for Biology of Aging

C 11- Understanding the mechanisms underlying early kidney failure in ARPKD: An in-depth translational approach to analyze the effects of Pkhd1 variants in preclinical models and patient tissue
Max C Liebau1 | Bernhard Schermer2
1Clinic for Pediatric and Adolescent Medicine | 2Clinic II of Internal Medicine

C 12 - Skin insulin resistance in type II diabetes and its associated diseases
Carien M Niessen1 | Ruth Hanßen2
1Dept. Cell Biology of the Skin and CECAD | 2Inst. of Metabolic Science, Cambridge University, UK

C 13 - Role of TNF-mediated inflammatory signaling in heart failure with preserved ejection fraction (HFpEF) and associated pulmonary hypertension (PH)
Stephan Rosenkranz | Marius Vantler - Clinic III for Internal Medicine

C 14 - Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways
Elena I Rugarli - Institute for Genetics and CECAD – Math.-Nat. Faculty

C 15 - Development of treatments for molybdenum cofactor and sulfite oxidase deficiency
Guenter Schwarz - Institute for Biochemistry – Math.-Nat. Faculty

C 16 - Correction of alterations in the ubiquitinated proteome to prevent age-related neurodegenerative diseases
David Vilchez - CECAD – Med. Faculty

C 17 - Bioactive lipid signaling in adult neurogenesis and metabolic modulation
Johannes Vogt | Lara-Jane Kepser - Institute for Anatomy II - Dept. of Molecular and Translational Neurosciences

C 18 - Vesicular trafficking and axonal local translation in health and motor neuron disease
Brunhilde Wirth | Valentina Piano - Institute of Human Genetics