The Aging Skin: From Basic Mechanisms to Clinical Application

The enormous progress in understanding the fundamental mechanisms affecting the cellular signaling pathways and the interplay among the different cell types operating in skin aging has inspired Prof. Dr. Björn Schumacher (Institute for Genome Stability in Ageing and Disease and CMMC) and Prof. Dr. Dr. Thomas Krieg (Translational Matrix Biology and CMMC) on this special issue “Aging and the Skin" of the Journal of Investigative Dermatology. This special issue (JID - Vol. 141, Issue 4, Supplement, S949-1126) is freely available: https://www.jidonline.org/issue/S0022-202X(21)X0003-6#closeFullCover)

Schumacher and Krieg succeeded to invite basic and clinician scientists, international renowned experts. In 20 articles the experts addressed the different aspects of aging skin on the molecular, cellular and tissue level and highlighted the translational aspects in presenting novel therapeutic concepts to combat aging-associated skin diseases and promote a healthy aging process.

Cologne scientists of the Medical Faculty at the University of Cologne, also affiliated with the CMMC and CECAD, contributed with following articles:

• Principles of the Molecular and Cellular Mechanisms of Aging
  PFL da Silva and B Schumacher
   
• Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer
  OD Persa, J Koester and CM Niessen
   
• Regulation of the Wound Healing Response during Aging
  X Ding, P Kakanj, M Leptin and SA Eming
   
• miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12
  M Auler, V Bergmeier, VS Georgieva, L Pitzler, C Frie, J Nüchel, B Eckes, B Hinz and B Brachvogel

The special edition is freely available and accessible:
https://www.jidonline.org/issue/S0022-202X(21)X0003-6#closeFullCover