Overview of the individual funded projects
(funding period 01/2014 - 12/2016)
Research Area A:
Mechanisms of tumor development: intrinsic control of cell proliferation and tissue invasion
A1
The multifaceted function of histone methylases and demethylases in lung cancer
Reinhard Büttner / Margarete Odenthal - Institute for Pathology
A2
Identification of small molecules blocking matriptase-dependent morphogenesis and carcinogenesis in zebrafish and mouse, and characterization of the relevant target proteins
Matthias Hammerschmidt - Institute for Developmental Biology
A3
Intrinsic and extrinsic functions of polarity proteins in melanoma formation and progression
Sandra Iden - CECAD Cologne
A4
Characterizing the molecular functions of the tumor suppressor protein Folliculin using the model organism Caenorhabditis elegans
Roman-Ulrich Müller / Francesca Fabretti - Dept. II of Internal Medicine
A5
Molecular function of Lef1 mutations (E45K/S61P and NLef1) in epithelial tissues and cancer
Catherin Niemann - Institute for Biochemistry II (Med. Faculty)
A6
Stem cell-specific role of NF-B signalling in cancer
Manolis Pasparakis - Institute for Genetics / CECAD Cologne
A7
Systematic identification of significantly mutated gene groups in cancer genomes by co-expression patterns
Martin Peifer - Dept. of Translational Genomics
A8
Differential modulation of the p53 network in cancer therapy
Hans Christian Reinhardt - Dept. I of Internal Medicine /
Björn Schumacher - CECAD Cologne
A9
Identification of new disease-causing and -modifying genes for familial breast and ovarian cancer
Rita Schmutzler / Eric Hahnen - Center of Familial Breast and Ovarian Cancer
Research Area B: Principles of immunity, inflammation and infection
B1
Deciphering the hierarchic organization of established solid tumor lesions
Hinrich Abken - Dept. I of Internal Medicine
B2Significance of leukocyte-mediated impairment of vascular integrity for the pathogenesis of heart failure, and leukocyte peroxidase inhibition as a novel therapeutic conceptStephan Baldus / Anna Klinke / Volker Rudolph - Dept. III of Internal Medicine
B3
Dynamic roles of podocytes in glomerular filtration and the progression of chronic kidney disease
Thomas Benzing - Dept. II of Internal Medicine
B4
Corticosteroid-mediated regulation of the human host response against intracellular pathogens
Mario Fabri - Dept. of Dermatology
B5
The ubiquitin ligase activity of XIAP in the pathogenesis of cancer
Hamid Kashkar - Institute for Med. Microbiology, Immunology and Hygiene
B6
NADPH oxidase (NOX)-generated reactive oxygen species (ROS): mechanisms of tissue-specific activation and pathophysiological implications for microbial infections
Martin Krönke / Olaf Utermöhlen - Institute for Med. Microbiology, Immunology and Hygiene
B7
How do mtDNA deletions lead to inflammation?
Rudolf Wiesner - Institute for Vegetative Physiology
Research Area C:
Molecular mechanisms and metabolic control of tissue degeneration and regeneration
C 1
Tailoring AAV vectors for cutaneous gene transfer and gene therapy
Hildegard Büning - Center for Molecular Medicine Cologne and Medical Univ. Hannover
C 2
Role of altered brain glucose metabolism in the pathogenesis of obesity and type 2 diabetes mellitus
Jens Brüning - Center for Endocrinology, Diabetes and Preventive Medicine
C 3
Mechanisms regulating age-associated decline of skin regenerative capacity
Sabine Eming - Dept. of Dermatology / Maria Leptin - Institute for Genetics / CECAD Cologne
C 4
Pathogenic role of cardiolipin in cardiomyopathies
Thomas Langer - Institute for Genetics / CECAD Cologne
C 5
Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration
Carien Niessen - Dept. of Dermatology / Paul Brinkkötter - Dept. II of Internal Medicine
C 6
Molecular basis of disturbed neurogenesis in primary microcephaly
Angelika Noegel - Institute for Biochemistry I / Peter Nürnberg - Cologne Center for Genomics (CCG)
C 7
Extracellular microfibrillar systems in disease pathogenesis: functional interactions in cytokine regulation, cellular differentiation and tissue homeostasis
Mats Paulsson / Raimund Wagener / Gerhard Sengle - Institute for Biochemistry II
C 8
Lipid droplets in neurodegenerative diseases
Elena Rugarli - Institute for Zoology / CECAD Cologne
C 9
The dynamic regulation of primary cilia in renal injury repair
Bernhard Schermer - Dept. II of Internal Medicine / Sandra Habbig / Max C. Liebau - Dept. of Pediatrics
C 10
Nitrite-dependent NO synthesis by sulfite oxidase
Guenter Schwarz - Institute for Biochemistry - Math.-Nat. Faculty
C11
Deciphering the modifying network counteracting spinal muscular atrophy and its translation into therapy
Brunhilde Wirth - Institute for Human Genetics
C12
Condensinopathies: Elucidation of novel molecular and functional mechanisms associated with congenital malformation and premature aging
Bernd Wollnik - present address Institute for Human Genetics, University Göttingen