(funding period 01/2017 - 12/2019)
Institute for Pathology
The multifaceted function of lysine-specific histone demethylase 1 in lung cancer
Dept. of Children and Adolescent Medicine
The functional and therapeutic significance of activated telomerase in neuroblastoma
Dept. I of Internal Medicine
Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies
Institute for Zoology
The multiple facts of the type II transmembrane serine protease ST14 and hypotonic stress during carcinogenesis in fish and mammals
Dept. for Internal Medicine I
Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias
CECAD Cologne
Requirement of polarity networks in melanoma cell plasticity, therapy and drug resistance
Institute for Biochemistry and CMMC
Mechanisms of stem cell-specific gatekeeper functions in cancer initiation
Institute for Genetics / CECAD Cologne
Immunogenic properties of necroptosis and apoptosis in stimulating anti-tumor immunity
Dept. for Translational Genomics1 / Dept. I for Internal Medicine2
Exploring actionable cooperating lesions that drive Myd88-mediated lymphomagenesis
Institute for Epigenomics
Epigenetic mechanisms of genomic instability and therapy resistance in cancer
Institute for Pathology
Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer
Institute for Genetics - CECAD Cologne
Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis
Dept. I of Internal Medicine
Metabolic addiction and reprogramming of an anti-tumor T cell response
Dept. III of Internal Medicine
Inflammatory pathways propagating ventricular arrhythmia - the role of myeloperoxidase for postischemic pro-arrhythmic remodeling
Dept. of Ophthalmology
Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency
Institute for Medical Microbiology, Immunology and Hygiene
The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation
Institute for Genome Stability in Aging and Disease, CECAD Cologne
Chronic inflammatory responses to persistent cytoplasmic DNA
Institute for Human Genetics1 / Cologne Center for Genomics2
Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney
Dept. II of Internal Medicine
The role of slit diaphragm signalling of podocytes
CECAD Cologne
Role of astrocytes in microvasculature remodeling following brain injury
CECAD Cologne1 / CMMC2
Contribution of deteriorating RNA biosynthesis to cellular ageing
Dept. II of Internal Medicine
Metabolic signaling at the kidney filtration barrier – role of insulin signaling on glomerular podocytes
Center for Clinical Endocrinology, Diabetology and Preventative Medicine
Fto-dependent regulation of hypothalamic neurons
Dept. of Dermatology1 / Institute for genetics2
The role of TOR pathway components in skin function
Institute for Molecular and Behavioral Neuroscience1 /Dept. of Neurology2
Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex
Institute for Genetics
Impaired mitochondrial proteostasis in CLPB associated disease
Dept. of Dermatology
Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration
Institute for Biochemistry I1 / Cologne Center for Genomics2
Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplasia
Dept. II for Internal Medicine / Dept. of Children and Adolescent Medicine2
The role of the cilia-cell-cycle connection in tissue homeostasis of renal tubular epithelium in acute and chronic kidney diseases
Institute for Biochemistry
Sulfite oxidase-dependent nitric oxide synthesis: Molecular mechanism, in vivo relevance and pharmacological targeting
Institute for Biochemistry I
Extracellular microfibrillar systems in disease pathogenesis: functional interactions in cytokine regulation, cellular differentiation and tissue homeostasis
Institute for Mitochondrial Diseases and Ageing
Manipulation of CLPP protease to complement mitochondrial respiratory deficiency
Institute for Human Genetics
Unraveling the molecular and cellular mechanism underlying spinal muscular atrophy of genetic modifiers