Center for Molecular Medicine Cologne

Summary of articles published by CMMC members in 2017

Selected publications related to CMMC-projects are listed in alphabetical order by the first author published in 2017.

  • Abken H (2017). Driving CARs on the Highway to Solid Cancer: Some Considerations on the Adoptive Therapy with CAR T Cells. Hum Gene Ther 28(11): 1047-1060.
     
  • Ahmad I, Baig SM, Abdulkareem AR, Hussain MS, Sur I, Toliat MR, Nurnberg G, Dalibor N, Moawia A, Waseem SS, Asif M, Nagra H, Sher M, Khan MMA, Hassan I, Rehman SU, Thiele H, Altmuller J, Noegel AA and Nurnberg P (2017). Genetic heterogeneity in Pakistani microcephaly families revisited. Clin Genet 92(1): 62-68.
     
  • Altmuller J, Haenisch B, Kawalia A, Menzen M, Nothen MM, Fier H and Molderings GJ (2017). Mutational profiling in the peripheral blood leukocytes of patients with systemic mast cell activation syndrome using next-generation sequencing. Immunogenetics 69(6): 359-369.
     
  • Amer W, Toth C, Vassella E, Meinrath J, Koitzsch U, Arens A, Huang J, Eischeid H, Adam A, Buettner R, Scheel A, Schaefer SC and Odenthal M (2017). Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra-deep sequencing of the mitochondrial genome. Sci Rep 7(1): 11069.
     
  • Appel S, Schulze-Edinghausen M, Kretschmer T, Storck S, Janoschek R, Bae-Gartz I, Handwerk M, Wohlfarth M, Nusken KD, Hucklenbruch-Rother E, Heykants M, Mahabir E and Dotsch J (2017). Maternal obesity attenuates predelivery inflammatory reaction in C57BL/6N mice. J Reprod Immunol 122: 10-13.
     
  • Aradjanski M, Dogan SA, Lotter S, Wang S, Hermans S, Wibom R, Rugarli E and Trifunovic A (2017). DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells. Hum Mol Genet 26(21): 4181-4189.
     
  • Ardicli D, Gocmen R, Talim B, Sprute R, Haliloglu G, Cirak S and Topaloglu H (2017). Congenital mirror movements in a patient with alpha-dystroglycanopathy due to a novel POMK mutation. Neuromuscul Disord 27(3): 239-242.
     
  • Awazawa M, Gabel P, Tsaousidou E, Nolte H, Kruger M, Schmitz J, Ackermann PJ, Brandt C, Altmuller J, Motameny S, Wunderlich FT, Kornfeld JW, Bluher M and Bruning JC (2017). A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat Med 23(12): 1466-1473.
     
  • Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Gobel H, Franke M, Schermer B, Haneder S, Benzing T, Beck BB and Muller RU (2017). Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC Med Genet 18(1): 53. Published online.
     
  • Batinica M, Stephan A, Steiger J, Tantcheva-Poomicronr I, Eming SA and Fabri M (2017). Stimulus-dependent NETosis by neutrophils from a Papillon-Lefevre Syndrome patient. J Eur Acad Dermatol Venereol 31(5): e239-e241
     
  • Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bauerle T, Hartwig J, Baumgart J, Kruger M, Radyushkin K, Alberi L, Berninger B and Schmidt MHH (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun 8: 15922. – epub.
     
  • Bragelmann J, Bohm S, Guthrie MR, Mollaoglu G, Oliver TG and Sos ML (2017). Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle 16(16): 1489-1498.
     
  • Bragelmann J, Dammert MA, Dietlein F, Heuckmann JM, Choidas A, Bohm S, Richters A, Basu D, Tischler V, Lorenz C, Habenberger P, Fang Z, Ortiz-Cuaran S, Leenders F, Eickhoff J, Koch U, Getlik M, Termathe M, Sallouh M, Greff Z, Varga Z, Balke-Want H, French CA, Peifer M, Reinhardt HC, Orfi L, Keri G, Ansen S, Heukamp LC, Buttner R, Rauh D, Klebl BM, Thomas RK and Sos ML (2017). Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma. Cell Rep 20(12): 2833-2845.
     
  • Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K and Sengle G (2017). Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models. Acta Biomater 52: 41-48.
     
  • Braun F and Brinkkoetter PT (2017). Is the Age-Related Decline in Renal Function an Age-Associated Disease or Part of a Normal Aging Process? Gerontology 63(4):325-326.
     
  • Brunn A, Mihelcic M, Carstov M, Feind L, Wieser EC, Schmidt J, Utermohlen O and Deckert M (2017). Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-gamma (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmune Neuritis. Am J Pathol 187(1): 42-54.
     
  • Bukowiecki A, Hos D, Cursiefen C and Eming SA (2017). Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities. Int J Mol Sci 18(6). doi: 10.3390/ijms18061257.
     
  • Bultmann-Mellin I, Dinger K, Debuschewitz C, Loewe KMA, Melcher Y, Plum MTW, Appel S, Rappl G, Willenborg S, Schauss AC, Jungst C, Kruger M, Dressler S, Nakamura T, Wempe F, Alejandre Alcazar MA and Sterner-Kock A (2017). Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs. Am J Physiol Lung Cell Mol Physiol 313(4): L687-L698.
     
  • Buttner R, Wolf J, Thomas RK and Sos ML (2017). Resistance Mechanisms to AZD9291 and Rociletinib-Response. Clin Cancer Res 23(14): 3967-3968.
     
  • Chacon-Martinez CA, Klose M, Niemann C, Glauche I and Wickstrom SA (2017). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBO J 36(2): 151-164.
     
  • Chaudhari U, Ellis JK, Wagh V, Nemade H, Hescheler J, Keun HC and Sachinidis A (2017). Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes. Amino Acids. 49(12): 1955–1963.
     
  • Chmielewski M and Abken H (2017). CAR T Cells Releasing IL-18 Convert to T-Bet(high) FoxO1(low) Effectors that Exhibit Augmented Activity against Advanced Solid Tumors. Cell Rep 21(11): 3205-3219.
     
  • Colaianna M, Ilmjarv S, Peterson H, Kern I, Julien S, Baquie M, Pallocca G, Bosgra S, Sachinidis A, Hengstler JG, Leist M and Krause KH (2017). Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay. Arch Toxicol 91(1): 365-391.
     
  • Corallo D, Schiavinato A, Bizzotto D, Milanetto M, Guljelmovic M, Keene DR, Sengle G, Braghetta P and Bonaldo P (2017). EMILIN3, an extracellular matrix molecule with restricted distribution in skin. Exp Dermatol 26(5): 435-438.
     
  • Crispatzu G, Kulkarni P, Toliat MR, Nurnberg P, Herling M, Herling CD and Frommolt P (2017). Semi-automated cancer genome analysis using high-performance computing. Hum Mutat 38(10): 1325-1335.
     
  • Cruz-Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, van Ijcken WFJ, Grosveld F, Frommolt P, Bazzi H and Rada-Iglesias A (2017). PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation. Cell Stem Cell 20(5): 689-705 e689.
     
  • De Rechter S, Kringen J, Janssens P, Liebau MC, Devriendt K, Levtchenko E, Bergmann C, Jouret F, Bammens B, Borry P, Schaefer F and Mekahli D (2017). Clinicians' attitude towards family planning and timing of diagnosis in autosomal dominant polycystic kidney disease. PLoS One 12(9): e0185779.
     
  • Dibue-Adjei M, Kamp MA, Alpdogan S, Tevoufouet EE, Neiss WF, Hescheler J and Schneider T (2017). Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo. Cell Physiol Biochem 44(3): 935-947.
     
  • Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Bruning JC, Spanswick D, Cowley MA and Tiganis T (2017). A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metab 26(3): 375-393.e7.
     
  • Ebner K, Dafinger C, Ortiz-Bruechle N, Koerber F, Schermer B, Benzing T, Dotsch J, Zerres K, Weber LT, Beck BB and Liebau MC (2017). Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations. Pediatr Nephrol 32(7): 1269-1273.
     
  • Ebner K, Reintjes N, Feldkotter M, Korber F, Nagel M, Dotsch J, Hoppe B, Weber LT, Beck BB and Liebau MC (2017). A case report on the exceptional coincidence of two inherited renal disorders: ADPKD and Alport syndrome. Clin Nephrol 88(1): 45-51.
     
  • Ebner K, Schaefer F, Liebau MC and Consortium AR (2017). Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease. Front Pediatr 5: 18. doi: 10.3389/fped.2017.00018.
     
  • Eckes B, Wang F, Moinzadeh P, Hunzelmann N and Krieg T (2017). Pathophysiological Mechanisms in Sclerosing Skin Diseases. Front Med (Lausanne) 4: 120. doi: 10.3389/fmed.2017.00120.
     
  • Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Kruger M and Schumacher B (2017). Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. Cell Rep 20(9): 2026-2043.
     
  • Ehmke N, Graul-Neumann L, Smorag L, Koenig R, Segebrecht L, Magoulas P, Scaglia F, Kilic E, Hennig AF, Adolphs N, Saha N, Fauler B, Kalscheuer VM, Hennig F, Altmuller J, Netzer C, Thiele H, Nurnberg P, Yigit G, Jager M, Hecht J, Kruger U, Mielke T, Krawitz PM, Horn D, Schuelke M, Mundlos S, Bacino CA, Bonnen PE, Wollnik B, Fischer-Zirnsak B and Kornak U (2017). De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. Am J Hum Genet 101(5): 833-843.
     
  • Eich G, Bartosova M, Tischer C, Wlodkowski TT, Schaefer B, Pichl S, Kraewer N, Ranchin B, Vondrak K, Liebau MC, Hackert T and Schmitt CP (2017). Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation. PLoS One 12(12): e0189903.
     
  • Eming SA, Wynn TA and Martin P (2017). Inflammation and metabolism in tissue repair and regeneration. Science 356(6342): 1026-1030.
     
  • Franke M, Baessler B, Vechtel J, Dafinger C, Hohne M, Borgal L, Gobel H, Koerber F, Maintz D, Benzing T, Schermer B and Persigehl T (2017). Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease. Kidney Int 92(6): 1544-1554.
     
  • Franko A, Kunze A, Bose M, von Kleist-Retzow JC, Paulsson M, Hartmann U and Wiesner RJ (2017). Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/--IRS-1+/- Double Heterozygous (IR-IRS1dh) Mice. Int J Mol Sci 18(6). 1156, doi: 10.3390/ijms18061156.
     
  • Franzen J, Zirkel A, Blake J, Rath B, Benes V, Papantonis A and Wagner W (2017). Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells. Aging Cell 16(1): 183-191.
     
  • Franzoso FD, Seyffert M, Vogel R, Yakimovich A, de Andrade Pereira B, Meier AF, Sutter SO, Tobler K, Vogt B, Greber UF, Buning H, Ackermann M and Fraefel C (2017). Cell cycle-dependent expression of AAV2 Rep in HSV-1 co-infections gives rise to a mosaic of cells replicating either AAV2 or HSV-1. J Virol. doi: 10.1128/JVI.00357-17. o
     
  • Gabriel E and Gopalakrishnan J (2017). Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders. J Vis Exp(122). doi: 10.3791/55372.
     
  • Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Kronke M, Utermohlen O and Gopalakrishnan J (2017). Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell 20(3): 397-406 e395. doi: 10.1016/j.stem.2016.12.005.
     
  • Gaspar JA, Srinivasan SP, Sureshkumar P, Doss MX, Hescheler J, Papadopoulos S and Sachinidis A (2017). Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives. Sci Rep 7(1): 14285. doi: 10.1038/s41598-017-14561-z.
     
  • Geoerger B, Bourdeaut F, DuBois SG, Fischer M, Geller JI, Gottardo NG, Marabelle A, Pearson ADJ, Modak S, Cash T, Robinson GW, Motta M, Matano A, Bhansali SG, Dobson JR, Parasuraman S and Chi SN (2017). A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors. Clin Cancer Res 23(10): 2433-2441.
     
  • George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Buttner R, Harris CC, Yokota J, Thomas RK and Kohno T (2017). Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res 23(5): 1220-1226.
     
  • Gioia R, Tonelli F, Ceppi I, Biggiogera M, Leikin S, Fisher S, Tenedini E, Yorgan TA, Schinke T, Tian K, Schwartz JM, Forte F, Wagener R, Villani S, Rossi A and Forlino A (2017). The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta. Hum Mol Genet. 26(15): 2897–2911.
     
  • Gkogkolou P, Hildebrandt K, Broekaert S, Metze D, Sengle G and Bohm M (2017). Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration. Br J Dermatol 176(3): 832-835.
     
  • Gobel J, Motori E and Bergami M (2017). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2017.06.191.
     
  • Golumba-Nagy V, Kuehle J and Abken H (2017). Genetic Modification of T Cells with Chimeric Antigen Receptors: A Laboratory Manual. Hum Gene Ther Methods. 28(6): 302-309.
     
  • Goranci-Buzhala G, Gabriel E, Mariappan A and Gopalakrishnan J (2017). Losers of Primary Cilia Gain the Benefit of Survival. Cancer Discov 7(12): 1374-1375.
     
  • Gordon CT, Xue S, Yigit G, Filali H, Chen K, Rosin N, Yoshiura KI, Oufadem M, Beck TJ, McGowan R, Magee AC, Altmuller J, Dion C, Thiele H, Gurzau AD, Nurnberg P, Meschede D, Muhlbauer W, Okamoto N, Varghese V, Irving R, Sigaudy S, Williams D, Ahmed SF, Bonnard C, Kong MK, Ratbi I, Fejjal N, Fikri M, Elalaoui SC, Reigstad H, Bole-Feysot C, Nitschke P, Ragge N, Levy N, Tuncbilek G, Teo AS, Cunningham ML, Sefiani A, Kayserili H, Murphy JM, Chatdokmaiprai C, Hillmer AM, Wattanasirichaigoon D, Lyonnet S, Magdinier F, Javed A, Blewitt ME, Amiel J, Wollnik B and Reversade B (2017). De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development. Nat Genet 49(2): 249-255.
     
  • Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kuhne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB and Theilig F (2017). mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol 28(1): 230-241.
     
  • Grimm D and Buning H (2017). Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution. Hum Gene Ther 28(11): 1075-1086.
     
  • Hackl A, Ehren R, Kirschfink M, Zipfel PF, Beck BB, Weber LT and Habbig S (2017). Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS. Pediatr Nephrol 32(6): 1081-1087.
     
  • Hackl A, Mehler K, Gottschalk I, Vierzig A, Eydam M, Hauke J, Beck BB, Liebau MC, Ensenauer R, Weber LT and Habbig S (2017). Disorders of fatty acid oxidation and autosomal recessive polycystic kidney disease-different clinical entities and comparable perinatal renal abnormalities. Pediatr Nephrol 32(5): 791-800.
     
  • Hagedorn C, Schnodt-Fuchs M, Boehme P, Abdelrazik H, Lipps HJ and Buning H (2017). S/MAR Element Facilitates Episomal Long-Term Persistence of Adeno-Associated Virus Vector Genomes in Proliferating Cells. Hum Gene Ther. 28(12): 1169-1179.
     
  • Hahn O, Gronke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W and Partridge L (2017). Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol 18(1): 56, doi: 10.1186/s13059-017-1187-1.
     
  • Haliloglu G, Becker K, Temucin C, Talim B, Kucuksahin N, Pergande M, Motameny S, Nurnberg P, Aydingoz U, Topaloglu H and Cirak S (2017). Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects. J Hum Genet 62(4): 497-501.
     
  • Hamdi Y, Soucy P, Kuchenbaeker KB, Pastinen T, Droit A, Lemacon A, Adlard J, Aittomaki K, Andrulis IL, Arason A, Arnold N, Arun BK, Azzollini J, Bane A, Barjhoux L, Barrowdale D, Benitez J, Berthet P, Blok MJ, Bobolis K, Bonadona V, Bonanni B, Bradbury AR, Brewer C, Buecher B, Buys SS, Caligo MA, Chiquette J, Chung WK, Claes KB, Daly MB, Damiola F, Davidson R, De la Hoya M, De Leeneer K, Diez O, Ding YC, Dolcetti R, Domchek SM, Dorfling CM, Eccles D, Eeles R, Einbeigi Z, Ejlertsen B, Embrace, Engel C, Gareth Evans D, Feliubadalo L, Foretova L, Fostira F, Foulkes WD, Fountzilas G, Friedman E, Frost D, Ganschow P, Ganz PA, Garber J, Gayther SA, Collaborators GS, Gerdes AM, Glendon G, Godwin AK, Goldgar DE, Greene MH, Gronwald J, Hahnen E, Hamann U, Hansen TV, Hart S, Hays JL, Hebon, Hogervorst FB, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Joseph V, Just W, Kaczmarek K, Karlan BY, Investigators KC, Kets CM, Kirk J, Kriege M, Laitman Y, Laurent M, Lazaro C, Leslie G, Lester J, Lesueur F, Liljegren A, Loman N, Loud JT, Manoukian S, Mariani M, Mazoyer S, McGuffog L, Meijers-Heijboer HE, Meindl A, Miller A, Montagna M, Mulligan AM, Nathanson KL, Neuhausen SL, Nevanlinna H, Nussbaum RL, Olah E, Olopade OI, Ong KR, Oosterwijk JC, Osorio A, Papi L, Park SK, Pedersen IS, Peissel B, Segura PP, Peterlongo P, Phelan CM, Radice P, Rantala J, Rappaport-Fuerhauser C, Rennert G, Richardson A, Robson M, Rodriguez GC, Rookus MA, Schmutzler RK, Sevenet N, Shah PD, Singer CF, Slavin TP, Snape K, Sokolowska J, Sonderstrup IM, Southey M, Spurdle AB, Stadler Z, Stoppa-Lyonnet D, Sukiennicki G, Sutter C, Tan Y, Tea MK, Teixeira MR, Teule A, Teo SH, Terry MB, Thomassen M, Tihomirova L, Tischkowitz M, Tognazzo S, Toland AE, Tung N, van den Ouweland AM, van der Luijt RB, van Engelen K, van Rensburg EJ, Varon-Mateeva R, Wappenschmidt B, Wijnen JT, Rebbeck T, Chenevix-Trench G, Offit K, Couch FJ, Nord S, Easton DF, Antoniou AC and Simard J (2017). Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3. Breast Cancer Res Treat 161(1): 117-134.
     
  • Harter P, Hauke J, Heitz F, Reuss A, Kommoss S, Marme F, Heimbach A, Prieske K, Richters L, Burges A, Neidhardt G, de Gregorio N, El-Balat A, Hilpert F, Meier W, Kimmig R, Kast K, Sehouli J, Baumann K, Jackisch C, Park-Simon TW, Hanker L, Krober S, Pfisterer J, Gevensleben H, Schnelzer A, Dietrich D, Neunhoffer T, Krockenberger M, Brucker SY, Nurnberg P, Thiele H, Altmuller J, Lamla J, Elser G, du Bois A, Hahnen E and Schmutzler R (2017). Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1). PLoS One 12(10): e0186043.
     
  • Herling M, Rengstl B, Scholtysik R, Hartmann S, Kuppers R, Hansmann ML, Diebner HH, Roeder I, Abken H, Newrzela S and Kirberg J (2017). Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology. Leuk Lymphoma 58(4): 788-796.
     
  • Holzinger A and Abken H (2017). CAR T cells targeting solid tumors: carcinoembryonic antigen (CEA) proves to be a safe target. Cancer Immunol Immunother 66(11): 1505-1507.
     
  • Hombach AA and Abken H (2017). Most Do, but Some Do Not: CD4(+)CD25(-) T Cells, but Not CD4(+)CD25(+) Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR). Cancers (Basel) 9(9): 112, doi: 10.3390/cancers9090112. o
     
  • Hombach AA and Abken H (2017). Shared target antigens on cancer cells and tissue stem cells: go or no-go for CAR T cells? Expert Rev Clin Immunol 13(2): 151-155.
     
  • Horpaopan S, Kirfel J, Peters S, Kloth M, Huneburg R, Altmuller J, Drichel D, Odenthal M, Kristiansen G, Strassburg C, Nattermann J, Hoffmann P, Nurnberg P, Buttner R, Thiele H, Kahl P, Spier I and Aretz S (2017). Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS). Hered Cancer Clin Pract 15: 22, doi: 10.1186/s13053-017-0082-9.
     
  • Horstmann J, Schulz-Hildebrandt H, Bock F, Siebelmann S, Lankenau E, Huttmann G, Steven P and Cursiefen C (2017). Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography. Invest Ophthalmol Vis Sci 58(13): 5880-5886.
     
  • Hos D, Bukowiecki A, Horstmann J, Bock F, Bucher F, Heindl LM, Siebelmann S, Steven P, Dana R, Eming SA and Cursiefen C (2017). Transient Ingrowth of Lymphatic Vessels into the Physiologically Avascular Cornea Regulates Corneal Edema and Transparency. Sci Rep 7(1): 7227, doi: 10.1038/s41598-017-07806-4.
     
  • Hos D, Tuac O, Schaub F, Stanzel TP, Schrittenlocher S, Hellmich M, Bachmann BO and Cursiefen C (2017). Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty: Retrospective Analysis of 1000 Consecutive Eyes. Ophthalmology 124(4): 512-518.
     
  • Hos NJ, Ganesan R, Gutierrez S, Hos D, Klimek J, Abdullah Z, Kronke M and Robinson N (2017). Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses. J Cell Biol 216(12): 4107-4121.
     
  • Hosel M, Huber A, Bohlen S, Lucifora J, Ronzitti G, Puzzo F, Boisgerault F, Hacker UT, Kwanten WJ, Kloting N, Bluher M, Gluschko A, Schramm M, Utermohlen O, Bloch W, Mingozzi F, Krut O and Buning H (2017). Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors. Hepatology 66(1): 252–265.
     
  • Hosel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Buning H, Heikenwalder M and Protzer U (2017). Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication. Cell Mol Gastroenterol Hepatol 4(3): 339-363.
     
  • Hosseinibarkooie S, Schneider S and Wirth B (2017). Advances in understanding the role of disease-associated proteins in spinal muscular atrophy. Expert Rev Proteomics 14(7): 581-592.
     
  • Hou Y, Le VNH, Clahsen T, Schneider AC, Bock F and Cursiefen C (2017). Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival. Invest Ophthalmol Vis Sci 58(13): 5862-5869.
     
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