Center for Molecular Medicine Cologne

Summary of articles published by CMMC members in 2014

Selected publications related to CMMC-projects are listed in alphabetical order by the first author published in 2014.

  • Ackermann S, Kocak H, Hero B, Ehemann V, Kahlert Y, Oberthuer A, Roels F, Theissen J, Odenthal M, Berthold F, and Fischer M (2014). Foxp1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma. BMC cancer 14, 840.
     
  • Altmuller J, Budde BS, and Nürnberg P (2014). Enrichment of target sequences for next-generation sequencing applications in research and diagnostics. Biol Chem 395, 231-237.
     
  • Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli EI, and Langer T (2014). The i-aaa protease yme1l and oma1 cleave opa1 to balance mitochondrial fusion and fission. J Cell Biol 204, 919-929.
     
  • Andree M, Seeger JM, Schull S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, and Kashkar H (2014). Bid-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against shigella. EMBO 32, 2171-87.
     
  • Bahat A, Perlberg S, Melamed-Book N, Lauria I, Langer T, and Orly J (2014). Star enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation. Mol Endocrinol 28, 208-224.
     
  • Baker MJ, Lampe PA, Stojanovski D, Korwitz A, Anand R, Tatsuta T, and Langer T (2014). Stress-induced oma1 activation and autocatalytic turnover regulate opa1-dependent mitochondrial dynamics. EMBO J 33, 578-593.
     
  • Basmanav FB, Oprisoreanu AM, Pasternack SM, Thiele H, Fritz G, Wenzel J, Grosser L, Wehner M, Wolf S, Fagerberg C, Bygum A, Altmüller J, Rutten A, Parmentier L, El Shabrawi-Caelen L, Hafner C, Nürnberg P, Kruse R, Schoch S, Hanneken S, and Betz RC (2014). Mutations in poglut1, encoding protein o-glucosyltransferase 1, cause autosomal-dominant dowling-degos disease. Am J Hum Genes 94, 135-143.
     
  • Beck BB, Phillips JB, Bartram MP, Wegner J, Thoenes M, Pannes A, Sampson J, Heller R, Gobel H, Koerber F, Neugebauer A, Hedergott A, Nürnberg G, Nürnberg P, Thiele H, Altmüller J, Toliat MR, Staubach S, Boycott KM, Valente EM, Janecke AR, Eisenberger T, Bergmann C, Tebbe L, Wang Y, Wu Y, Fry AM, Westerfield M, Wolfrum U, and Bolz HJ (2014). Mutation of poc1b in a severe syndromic retinal ciliopathy. Hum Mutat 35, 1153-1162.
     
  • Becker AK, Mikolajek H, Paulsson M, Wagener R, and Werner JM (2014). A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein. Structure 22, 199-208.
     
  • Bognar P, Nemeth I, Mayer B, Haluszka D, Wikonkal N, Ostorhazi E, John S, Paulsson M, Smyth N, Pasztoi M, Buzas EI, Szipocs R, Kolonics A, Temesvari E, and Karpati S (2014). Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice. J Invest Dermatol 134, 105-111.
     
  • Bonar D, and Hanisch FG (2014). Trefoil factor family domains represent highly efficient conformational determinants for n-linked n,n'-di-n-acetyllactosediamine (lacdinac) synthesis. J Biol Chem 289, 29677-29690.
     
  • Borck G, de Vries L, Wu HJ, Smirin-Yosef P, Nürnberg G, Lagovsky I, Ishida LH, Thierry P, Wieczorek D, Nürnberg P, Foley J, Kubisch C, and Basel-Vanagaite L (2014). Homozygous truncating ptprf mutation causes athelia. Hum Genet 133, 1041-7.
     
  • Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, and Schermer B (2014). Casein kinase 1 alpha phosphorylates the wnt regulator jade-1 and modulates its activity. J Biol Chem 289, 26344-26356.
     
  • Breitenkamp AF, Matthes J, Nass RD, Sinzig J, Lehmkuhl G, Nürnberg P, and Herzig S (2014). Rare mutations of cacnb2 found in autism spectrum disease-affected families alter calcium channel function. PLoS One 9, e95579.
     
  • Brinkmann K, and Kashkar H (2014). Targeting the mitochondrial apoptotic pathway: A preferred approach in hematologic malignancies? Cell Death Dis 5, e1098.
     
  • Brinkmann K, Hombach A, Michael Seeger J, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, and Kashkar H (2014). SMAC mimetic potentiates tumor susceptibility towards natural killer cell-mediated killing. Leuk Lymphoma 55, 456-465.
     
  • Brown A, Augustin M, Junger M, Zutt M, Dissemond J, Rabe E, Kaufmann R, Simon M, Stucker M, Karrer S, Koenen W, Vanscheidt W, Scharfetter-Kochanek K, Wollina U, Krieg T, and Eming SA (2014). Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. Eur J Dermatol 24, 210-216.
     
  • Brunn A, Mihelcic M, Carstov M, Hummel L, Geier F, Schmidt A, Saupe L, Utermöhlen O, and Deckert M (2014a). Il-10, Il-4, and stat6 promote an m2 milieu required for termination of p0106-125-induced murine experimental autoimmune neuritis. Am J Pathol 184, 2627-2640.
     
  • Brunn A, Utermöhlen O, Mihelcic M, Saupe L, Fiocco Z, Schmidt A, Carstov M, Montesinos-Rongen M, and Deckert M (2014). Costimulatory molecule cd40 is essential for myelin protein 0 peptide 106-125-induced experimental autoimmune neuritis in mice. J Neuropathol Exp Neurol 73, 454-466.
     
  • Burgute BD, Peche VS, Steckelberg AL, Glockner G, Gassen B, Gehring NH, and Noegel AA (2014). Nkap is a novel rs-related protein that interacts with rna and rna binding proteins. Nucleic Acids Res 42, 3177-3193.
     
  • Burtscher V, Schicker K, Novikova E, Pohn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, and Koschak A (2014). Spectrum of cav1.4 dysfunction in congenital stationary night blindness type 2. Biochim Biophys Acta 1838, 2053-2065.
     
  • Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jockel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, and Trumpp A (2014). Improved hsc reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med 211, 769-779.
     
  • Chatterjee S, Wieczorek C, Schottle J, Siobal M, Hinze Y, Franz T, Florin A, Adamczak J, Heukamp LC, Neumaier B, and Ullrich RT (2014). Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer. Cancer Res 74, 2816-2824.
     
  • Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, and Kashkar H (2014). Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med 6, 624-639.
     
  • Dahlhoff M, Frances D, Kloepper JE, Paus R, Schafer M, Niemann C, and Schneider MR (2014). Overexpression of epigen during embryonic development induces reversible, egfr-dependent sebaceous gland hyperplasia. Mol Cell Biol 34, 3086-9.
     
  • Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, and Pasparakis M (2014). Ripk1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513, 90-94.
     
  • Dejanovic B, and Schwarz G (2014). Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at gabaergic synapses. J Neurosci 34, 7763-7768.
     
  • Dejanovic B, Lal D, Catarino CB, Arjune S, Belaidi AA, Trucks H, Vollmar C, Surges R, Kunz WS, Motameny S, Altmüller J, Kohler A, Neubauer BA, Epicure C, Nürnberg P, Noachtar S, Schwarz G, and Sander T (2014). Exonic microdeletions of the gephyrin gene impair gabaergic synaptic inhibition in patients with idiopathic generalized epilepsy. Neurobiol Dis 67, 88-96.
     
  • Dejanovic B, Semtner M, Ebert S, Lamkemeyer T, Neuser F, Luscher B, Meier JC, and Schwarz G (2014). Palmitoylation of gephyrin controls receptor clustering and plasticity of gabaergic synapses. PLoS Biol 12, e1001908.
     
  • Dibue M, Kamp MA, Neumaier F, Steiger HJ, Hanggi D, Hescheler J, and Schneider T (2014). Cardiac phenomena during kainic-acid induced epilepsy and lamotrigine antiepileptic therapy. Epilepsy Res 108, 666-674.
     
  • Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Langst G, and Papantonis A (2014). Tnf-alpha signalling primes chromatin for nf-kappa b binding and induces rapid and widespread nucleosome repositioning. Genome biology 15, 536.
     
  • Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, and Trifunovic A (2014). Tissue-specific loss of dars2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab 19, 458-469.
     
  • Doss S, Lohmann K, Seibler P, Arns B, Klopstock T, Zuhlke C, Freimann K, Winkler S, Lohnau T, Drungowski M, Nürnberg P, Wiegers K, Lohmann E, Naz S, Kasten M, Bohner G, Ramirez A, Endres M, and Klein C (2014). Recessive dystonia-ataxia syndrome in a turkish family caused by a cox20 (fam36a) mutation. J Neurol 261, 207-212.
     
  • Dreidax D, Bannert S, Henrich KO, Schroder C, Bender S, Oakes CC, Lindner S, Schulte JH, Duffy D, Schwarzl T, Saadati M, Ehemann V, Benner A, Pfister S, Fischer M, and Westermann F (2014). P19-ink4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in mycn-amplified neuroblastomas. Hum Mol Genet 23, 6826-376.
     
  • Eckes B, Krieg T, and Wickstrom SA (2014). Role of integrin signaling through integrin-linked kinase (ilk) in skin physiology and pathology. Exp Dermatol 23, 453-6.
     
  • Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, and Krieg T (2014). Molecular and cellular basis of scleroderma. J Mol Med (Berl) 92, 913-924.
     
  • Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, and Tassin AM (2014). The deubiquitinating enzyme cyld controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun 5, 4585.
     
  • Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, and Pasparakis M (2014). Death receptor-independent fadd signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific nemo knockout. Cell Death Differ 21, 1721-32.
     
  • Elsayed SM, Heller R, Thoenes M, Zaki MS, Swan D, Elsobky E, Zuhlke C, Ebermann I, Nürnberg G, Nürnberg P, and Bolz HJ (2014). Autosomal dominant sca5 and autosomal recessive infantile sca are allelic conditions resulting from sptbn2 mutations. Eur J Hum Genet 22, 286-288.
     
  • Eming SA (2014). Evolution of immune pathways in regeneration and repair: Recent concepts and translational perspectives. Semin Immunol 26, 275-276.
     
  • Escobar-Henriques M, and Langer T (2014). Dynamic survey of mitochondria by ubiquitin. EMBO Rep 15, 231-243.
     
  • Fabian J, Lodrini M, Oehme I, Schier MC, Thole TM, Hielscher T, Kopp-Schneider A, Opitz L, Capper D, von Deimling A, Wiegand I, Milde T, Mahlknecht U, Westermann F, Popanda O, Roels F, Hero B, Berthold F, Fischer M, Kulozik AE, Witt O, and Deubzer HE (2014). Grhl1 acts as tumor suppressor in neuroblastoma and is negatively regulated by mycn and hdac3. Cancer Res 74, 2604-2616.
     
  • Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozretic L, Seidel D, Zander T, Leenders F, George J, Müller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmüller J, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland A, Solberg S, Lund-Iversen M, Ansen S, Stoelben E, Wright GM, Russell P, Wainer Z, Solomon B, Field JK, Hyde R, Davies MP, Heukamp LC, Petersen I, Perner S, Lovly CM, Cappuzzo F, Travis WD, Wolf J, Vingron M, Brambilla E, Haas SA, Büttner R, and Thomas RK (2014). Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids. Nat Commun 5, 3518.
     
  • Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Dassler J, Malchers F, Schottle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmüller J, Becker C, Nürnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sanger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Büttner R, Zander T, Wolf J, Perner S, Ansen S, Haas SA, Yatabe Y, and Thomas RK (2014). Cd74-nrg1 fusions in lung adenocarcinoma. Cancer Discov 4, 415-422.
     
  • Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, Schmelzer E, Bloch W, Carney TJ, and Hammerschmidt M (2014). P53 and tap63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet 10, e1004048.
     
  • Florea F, Bernards C, Caproni M, Kleindienst J, Hashimoto T, Koch M, and Sitaru C (2014). Ex vivo pathogenicity of anti-laminin gamma1 autoantibodies. Am J Pathol 184, 494-506.
     
  • Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Bose M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, and Wiesner RJ (2014). Liver adapts mitochondrial function to insulin resistant and diabetic states in mice. J Hepatol 60, 816-823.
     
  • Frohlich M, Dejanovic B, Kashkar H, Schwarz G, and Nussberger S (2014). S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of bax and initiation of apoptosis. Cell Death Dis 5, e1057.
     
  • Gao J, Schatton D, Martinelli P, Hansen H, Pla-Martin D, Barth E, Becker C, Altmueller J, Frommolt P, Sardiello M, and Rugarli EI (2014). Cluh regulates mitochondrial biogenesis by binding mrnas of nuclear-encoded mitochondrial proteins. J Cell Biol 207, 213-223.
     
  • Gee HY, Otto EA, Hurd TW, Ashraf S, Chaki M, Cluckey A, Vega-Warner V, Saisawat P, Diaz KA, Fang H, Kohl S, Allen SJ, Airik R, Zhou W, Ramaswami G, Janssen S, Fu C, Innis JL, Weber S, Vester U, Davis EE, Katsanis N, Fathy HM, Jeck N, Klaus G, Nayir A, Rahim KA, Al Attrach I, Al Hassoun I, Ozturk S, Drozdz D, Helmchen U, O'Toole JF, Attanasio M, Lewis RA, Nürnberg G, Nürnberg P, Washburn J, MacDonald J, Innis JW, Levy S, and Hildebrandt F (2014). Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies. Kidney Int 85, 880-887.
     
  • Geibel M, Badurek S, Horn JM, Vatanashevanopakorn C, Koudelka J, Wunderlich CM, Bronneke HS, Wunderlich FT, and Minichiello L (2014). Ablation of trkb signalling in cck neurons results in hypercortisolism and obesity. Nat Commun 5, 3427.
     
  • Glockner G, Hulsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, and Schliwa M (2014). The genome of the foraminiferan reticulomyxa filosa. Curr Biol 24, 11-18.
     
  • Gravemann S, Brinkkötter PT, Vehreschild JJ, Franke B, Ehren K, Bunemann E, Orbach H, Wei V, Hellmich M, Benzing T, and Fatkenheuer G (2014). Low-grade proteinuria is highly prevalent in hiv-positive patients on antiretroviral treatment. AIDS. DOI: 10.1097/QAD.0000000000000324.
     
  • Guay-Woodford LM, Bissler JJ, Braun MC, Bockenhauer D, Cadnapaphornchai MA, Dell KM, Kerecuk L, Liebau MC, Alonso-Peclet MH, Shneider B, Emre S, Heller T, Kamath BM, Murray KF, Moise K, Eichenwald EE, Evans J, Keller RL, Wilkins-Haug L, Bergmann C, Gunay-Aygun M, Hooper SR, Hardy KK, Hartung EA, Streisand R, Perrone R, and Moxey-Mims M (2014). Consensus expert recommendations for the diagnosis and management of autosomal recessive polycystic kidney disease: Report of an international conference. J Pediatr 165, 611-7.
     
  • Hagmann H, Bossung V, Belaidi AA, Fridman A, Karumanchi SA, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, and Brinkkötter PT (2014). Low-molecular weight heparin increases circulating sflt-1 levels and enhances urinary elimination. PLoS One 9, e85258.
     
  • Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, and Brinkkötter PT (2014). Breaking the chain at the membrane: Paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J 28, 1769-1779.
     
  • Hanisch FG, Bonar D, Schloerer N, and Schroten H (2014). Human trefoil factor 2 is a lectin that binds alpha-glcnac-capped mucin glycans with antibiotic activity against helicobacter pylori. J Biol Chem 289, 27363-27375.
     
  • Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W, Müller S, Hanisch FG, Franz T, Li X, Dicken HD, Eckardt K, Beckers J, de Angelis MH, Weigert C, Haring HU, Al-Hasani H, Ouwens DM, Eckel J, Kotzka J, and Lehr S (2014). Secretome profiling of primary human skeletal muscle cells. Biochim Biophys Acta 1844, 1011-1017.
     
  • Havarushka N, Fischer-Schrader K, Lamkemeyer T, and Schwarz G (2014). Structural basis of thermal stability of the tungsten cofactor synthesis protein moab from pyrococcus furiosus. PLoS One 9, e86030.
     
  • Herrmann G, Knudsen L, Madershahian N, Muhlfeld C, Frank K, Rahmanian P, Wahlers T, Wittwer T, and Ochs M (2014). Effects of exogenous surfactant on the non-heart-beating donor lung graft in experimental lung transplantation - a stereological study. J Anat 224, 594-602.
     
  • Hess ME, and Brüning JC (2014). The fat mass and obesity-associated (fto) gene: Obesity and beyond? Biochim Biophys Acta 1842, 2039-4.
     
  • Horner M, Kaufmann B, Cotugno G, Wiedtke E, Büning H, Grimm D, and Weber W (2014). A chemical switch for controlling viral infectivity. Chem Commun (Camb) 50, 10319-10322.
     
  • Hosel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, and Büning H (2014). Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo. Hepatology 59, 2110-2120.
     
  • Hoyer-Kuhn H, Semler O, Garbes L, Zimmermann K, Becker J, Wollnik B, Schoenau E, and Netzer C (2014). A nonclassical ifitm5 mutation located in the coding region causes severe osteogenesis imperfecta with prenatal onset. J Bone Miner Res 29, 1387-1391.
     
  • Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara S, Altmuller J, Thiele H, Nurnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Smigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, and Nurnberg P (2014). Mutations in ckap2l, the human homolog of the mouse radmis gene, cause filippi syndrome. Am J Hum Gen 95, 622-632.
     
  • Kelly BT, Graham SC, Liska N, Dannhauser PN, Höning S, Ungewickell EJ, and Owen DJ (2014). Clathrin adaptors. Ap2 controls clathrin polymerization with a membrane-activated switch. Science 345, 459-463.
     
  • Keusekotten K, Bade VN, Meyer-Teschendorf K, Sriramachandran AM, Fischer-Schrader K, Krause A, Horst C, Schwarz G, Hofmann K, Dohmen RJ, and Praefcke GJ (2014). Multivalent interactions of the sumo-interaction motifs in ring finger protein 4 determine the specificity for chains of the sumo. Biochem J 457, 207-214.
     
  • Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmüller J, Steinmetz MO, Enzinger C, Thiele H, Hohne W, Nürnberg G, Baig SM, Ansar M, Nürnberg P, Vincent JB, Speicher MR, Gonczy P, and Windpassinger C (2014). A missense mutation in the pisa domain of hssas-6 causes autosomal recessive primary microcephaly in a large consanguineous pakistani family. Hum Mol Genet 23, 5940-9.
     
  • Kim C, and Pasparakis M (2014a). Epidermal p65/nf-kappa b signalling is essential for skin carcinogenesis. EMBO Mol Med 6, 970-983.
     
  • Kim C, and Pasparakis M (2014b). Rip kinase 3 in necroptosis: Does it take two or more to kill? Cell Death Differ 21, 1505-1507.
     
  • Kobold S, Steffen J, Chaloupka M, Grassmann S, Henkel J, Castoldi R, Zeng Y, Chmielewski M, Schmollinger J, Schnurr M, Rothenfusser S, Schendel DJ, Abken H, Sustmann C, Niederfellner G, Klein C, Bourquin C, and Endres S (2014). Bispecific t cell recruiting antibody enhances anti-tumor activity of adoptive t cell transfer. Oncol Res Treat 37, 239-239.
     
  • Kohli P, Bartram MP, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, and Rinschen MM (2014). Label-free quantitative proteomic analysis of the yap/taz interactome. Am J Physiol Cell Physiol 306, C805-818.
     
  • Komlosi K, Hadzsiev K, Garbes L, Martinez Carrera LA, Pal E, Sigurethsson JH, Magnusson O, Melegh B, and Wirth B (2014). Exome sequencing identifies laing distal myopathy myh7 mutation in a roma family previously diagnosed with distal neuronopathy. Neuromuscul Disord 24, 156-161.
     
  • Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, and Rugarli EI (2014). Loss of the M-AAA protease subunit afg(3)l(2) causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J 33, 1011-1026.
     
  • Kornfeld JW, and Brüning JC (2014). Regulation of metabolism by long, non-coding rnas. Front Genet 5, 57.
     
  • Koziel R, Ruckenstuhl C, Albertini E, Neuhaus M, Netzberger C, Bust M, Madeo F, Wiesner RJ, and Jansen-Durr P (2014). Methionine restriction slows down senescence in human diploid fibroblasts. Aging cell 13, 1038-1048.
     
  • Krug C, Wiesinger M, Abken H, Schuler-Thurner B, Schuler G, Dorrie J, and Schaft N (2014). A gmp-compliant protocol to expand and transfect cancer patient T cells with mrna encoding a tumor-specific chimeric antigen receptor. Cancer Immunol Immunother 63, 999-1008.
     
  • Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flogel U, Rosenkranz S, Ricquier D, Kunz WS, and Trifunovic A (2014). Loss of ucp2 attenuates mitochondrial dysfunction without altering ros production and uncoupling activity. PLoS Genet 10, e1004385.
     
  • Kurschat CE, Muller RU, Franke M, Maintz D, Schermer B, and Benzing T (2014). An approach to cystic kidney diseases: The clinician's view. Nat Rev Nephrol 10, 687-699.
     
  • Kye MJ, Niederst ED, Wertz MH, Goncalves ID, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, and Sahin M (2014). SMN regulates axonal local translation via miR-183/mtor pathway. Hum Mol Genet 23, 6318-31.
     
  • Lepperhof V, Polchynski O, Kruttwig K, Bruggemann C, Neef K, Drey F, Zheng Y, Ackermann JP, Choi YH, Wunderlich FT, Hoehn M, Hescheler J, and Saric T (2014). Bioluminescent imaging of genetically selected induced pluripotent stem cell-derived cardiomyocytes after transplantation into infarcted heart of syngeneic recipients. PLoS One 9, e107363.
     
  • Lettmann S, Bloch W, Maass T, Niehoff A, Schulz JN, Eckes B, SA, Bonaldo P, Paulsson M, and Wagener R (2014). Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: Expression of classical and novel collagen VI variants during wound healing. PLoS One 9, e105686.
     
  • Li P, Meinke P, Huong le TT, Wehnert M, and Noegel AA (2014). Contribution of sun1 mutations to the pathomechanism in muscular dystrophies. Hum Mutat 35, 452-461.
     
  • Liebau MC (2014). An emerging molecular understanding and novel targeted treatment approaches in pediatric kidney diseases. Front Pediatr 2, 68.
     
  • Liggett JL, Choi CK, Donnell RL, Kihm KD, Kim JS, Min KW, Noegel AA, and Baek SJ (2014). Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein nesprin-2 expression in colorectal cancer cells. Bba-Gen Subjects 1840, 322-331.
     
  • Liu Y, Liu X, Hao W, Decker Y, Schomburg R, Fulop L, Pasparakis M, Menger MD, and Fassbender K (2014). IKKbeta deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci 34, 12982-12999.
     
  • Lohkamp LN, von Au K, Goebel HH, Kress W, Grieben U, Drossel K, Garbes L, Wirth B, Heppner FL, and Stenzel W (2014). A paucisymptomatic neuromuscular disease mimicking type III 5q-SMA with complex rearrangements in the SMN gene. J Child Neurol 29, 254-259.
     
  • Lu X, Thomas RK, and Peifer M (2014). Cgars: Cancer genome analysis by rank sums. Bioinformatics 30, 1295-1296.
     
  • Luo D, Fajol A, Umbach AT, Noegel AA, Laufer S, Lang F, and Foller M (2014). Influence of annexin a7 on insulin sensitivity of cellular glucose uptake. Pflugers Arch. 467, 641-9.
     
  • Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nurnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Muller R, Hoffmann I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmuller J, Hohne W, Hurles ME, Noegel AA, Baig SM, Nurnberg P, and Jackson AP (2014). Mutations in plk4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Gen 46, 1283-1292.
     
  • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Bronneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, and Brüning JC (2014). Signaling by il-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 15, 423-430.
     
  • Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Muller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, and Schumacher B (2014). Daf-16/foxo and egl-27/gata promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol 16, 1168-1179.
     
  • Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, Brandon J, Kleefstra T, Warris A, van der Flier M, Bamforth JS, Doonanco K, Ades L, Ma A, Field M, Johnson D, Shackley F, Firth H, Woods CG, Nürnberg P, Gatti RA, Hurles M, Bober MB, Wollnik B, and Jackson AP (2014). Extreme growth failure is a common presentation of ligase IV deficiency. Hum Mutat 35, 76-85.
     
  • Neacsu CD, Ko YP, Tagariello A, Rokenes Karlsen K, Neiss WF, Paulsson M, and Wagener R (2014). Matrilin-1 is essential for zebrafish development by facilitating collagen II secretion. J Biol Chem 289, 1505-1518.
     
  • Neerincx A, Jakobshagen K, Utermöhlen O, Büning H, Steimle V, and Kufer TA (2014). The n-terminal domain of nlrc5 confers transcriptional activity for mhc class I and II gene expression. J Immunol 193, 3090-3100.
     
  • Neuhaus JF, Baris OR, Hess S, Moser N, Schroder H, Chinta SJ, Andersen JK, Kloppenburg P, and Wiesner RJ (2014). Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons. Brain 137, 354-365.
     
  • Neumann S, and Noegel AA (2014). Nesprins in cell stability and migration. Adv Exp Med Biol 773, 491-504.
     
  • Niessen CM, and Krieg T (2014). Clinician scientists and phds: The need to connect basic research to translational medicine-a personal experience. J Invest Dermatol 134, 295-298.
     
  • Olsson KM, Delcroix M, Ghofrani HA, Tiede H, Huscher D, Speich R, Grunig E, Staehler G, Rosenkranz S, Halank M, Held M, Lange TJ, Behr J, Klose H, Claussen M, Ewert R, Opitz CF, Vizza CD, Scelsi L, Vonk-Noordegraaf A, Kaemmerer H, Gibbs JS, Coghlan G, Pepke-Zaba J, Schulz U, Gorenflo M, Pittrow D, and Hoeper MM (2014). Anticoagulation and survival in pulmonary arterial hypertension: Results from the comparative, prospective registry of newly initiated therapies for pulmonary hypertension (compera). Circulation 129, 57-65.
     
  • Omosigho NN, Swaminathan K, Plomann M, Müller-Taubenberger A, Noegel AA, and Riyahi TY (2014). The dictyostelium discoideum rack1 orthologue has roles in growth and development. Cell Commun Signal 12, 37.
     
  • Ostler N, Britzen-Laurent N, Liebl A, Naschberger E, Lochnit G, Ostler M, Forster F, Kunzelmann P, Ince S, Supper V, Praefcke GJ, Schubert DW, Stockinger H, Herrmann C, and Sturzl M (2014). Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor. Mol Cell Biol 34, 196-209.
     
  • Pan TC, Zhang RZ, Arita M, Bogdanovich S, Adams SM, Gara SK, Wagener R, Khurana TS, Birk DE, and Chu ML (2014). A mouse model for dominant collagen VI disorders. J Biol Chem 289, 10293-10307.
     
  • Pandey GK, Mitra S, Subhash S, Hertwig F, Kanduri M, Mishra K, Fransson S, Ganeshram A, Mondal T, Bandaru S, Ostensson M, Akyurek LM, Abrahamsson J, Pfeifer S, Larsson E, Shi LM, Peng ZY, Fischer M, Martinsson T, Hedborg F, Kogner P, and Kanduri C (2014). The risk-associated long noncoding rna nbat-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Cancer Cell 26, 722-737.
     
  • Pannu V, Rida PC, Celik B, Turaga RC, Ogden A, Cantuaria G, Gopalakrishnan J, and Aneja R (2014). Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells. Cell death & disease 5, e1538.
     
  • Pasparakis M, Haase I, and Nestle FO (2014). Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol 14, 289-301.
     
  • Patel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M, and Stetefeld J (2014). Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution. Matrix Biol 33, 60-67.
     
  • Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, and Latz E (2014). Cutting edge: The unc93b1 tyrosine-based motif regulates trafficking and tlr responses via separate mechanisms. J Immunol 193, 3257-3261.
     
  • Polykratis A, Hermance N, Zelic M, Roderick J, Kim C, Van TM, Lee TH, Chan FK, Pasparakis M, and Kelliher MA (2014). Cutting edge: Ripk1 kinase inactive mice are viable and protected from tnf-induced necroptosis in vivo. J Immunol 193, 1539-1543.
     
  • Powis RA, Mutsaers CA, Wishart TM, Hunter G, Wirth B, and Gillingwater TH (2014). Increased levels of uchl1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. Neuropathol Appl Neurobiol 40,873-87.
     
  • Rada-Iglesias A (2014). Genetic variation within transcriptional regulatory elements and its implications for human disease. Biol Chem 395, 1453-6009.
     
  • Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, and Wagener R (2014). Amaco is a component of the basement membrane-associated fraser complex. J Invest Dermatol 134, 1313-1322.
     
  • Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, and Langer T (2014). Dnajc19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metab 20, 158-7.
     
  • Rinschen MM, Schermer B, and Benzing T (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: From bench to bedside and back again. J Am Soc Nephrol 25, 1140-1147.
     
  • Rinschen MM, Wu X, Konig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, and Schurek EM, Volker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE, 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, and Hohne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (phb) domain protein podocin. J Biol Chem 289, 11262-11271.
     
  • Rinschen MM, Wu X, Konig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkötter PT, and Benzing T (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol 25, 1509-22.
     
  • Ritter C, Forster D, Albrecht P, Hartung HP, Kieseier BC, and Lehmann HC (2014). Ivig regulates baff expression in patients with chronic inflammatory demyelinating polyneuropathy (cidp). J Neuroimmunol 274, 225-229.
     
  • Roberts JM, Ennajdaoui H, Edmondson C, Wirth B, Sanford JR, and Chen B (2014). Splicing factor tra2b is required for neural progenitor survival. J Comp Neurol 522, 372-392.
     
  • Roderick JE, Hermance N, Zelic M, Simmons MJ, Polykratis A, Pasparakis M, and Kelliher MA (2014). Hematopoietic ripk1 deficiency results in bone marrow failure caused by apoptosis and ripk3-mediated necroptosis. Proc Natl Acad Sci U S A. 111, 14436-4.
     
  • Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Kessler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, Borchmann P, Yazaki P, Koslowsky TC, Engert A, Heukamp LC, Hallek M, and von Strandmann EP (2014). The bispecific immunoligand ulbp2-acea redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma. Int J Cancer 134, 2829-2840.
     
  • Rubach M, Adelmann R, Haustein M, Drey F, Pfannkuche K, Xiao B, Koester A, Udink ten Cate FE, Choi YH, Neef K, Fatima A, Hannes T, Pillekamp F, Hescheler J, Saric T, Brockmeier K, and Khalil M (2014). Mesenchymal stem cells and their conditioned medium improve integration of purified induced pluripotent stem cell-derived cardiomyocyte clusters into myocardial tissue. Stem Cells Dev 23, 643-653.
     
  • Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rubsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, and Büning H (2014). Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy. Mol Ther 22, 929-939.
     
  • Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, and Medzhitov R (2014). Signaling through the adaptor molecule myd88 in cd4+ t cells is required to overcome suppression by regulatory t cells. Immunity 40, 78-90.
     
  • Schessl J, Bach E, Rost S, Feldkirchner S, Kubny C, Muller S, Hanisch FG, Kress W, and Schoser B (2014). Novel recessive myotilin mutation causes severe myofibrillar myopathy. Neurogenetics 15, 151-156.
     
  • Schlereth SL, Refaian N, Iden S, Cursiefen C, and Heindl LM (2014). Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis. Biomed Res Int 2014, 639058.
     
  • Schorpp K, Rothenaigner I, Salmina E, Reinshagen J, Low T, Brenke JK, Gopalakrishnan J, Tetko IV, Gul S, and Hadian K (2014). Identification of small-molecule frequent hitters from alphascreen high-throughput screens. J Biomol Screen 19, 715-726.
     
  • Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Utermöhlen O, and Krönke M (2014). Riboflavin (vitamin b2 ) deficiency impairs nadph oxidase 2 (nox2) priming and defense against listeria monocytogenes. Eur J Immunol 44, 728-741.
     
  • Schreml J, Durmaz B, Cogulu O, Keupp K, Beleggia F, Pohl E, Milz E, Coker M, Ucar SK, Nürnberg G, Nürnberg P, Kuhn J, and Ozkinay F (2014). The missing "link": An autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation. Hum Genet 133, 29-39.
     
  • Schulz Y, Freese L, Manz J, Zoll B, Volter C, Brockmann K, Bogershausen N, Becker J, Wollnik B, and Pauli S (2014). Charge and kabuki syndromes: A phenotypic and molecular link. Hum Mol Genet 2, 4396-405.
     
  • Schurek EM, Volker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE, 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, and Hohne M (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (phb) domain protein podocin. J Biol Chem 289, 11262-11271.
     
  • Semkova I, Kociok N, Karagiannis D, Nischt R, Smyth N, Paulsson M, Strauss O, and Joussen AM (2014). Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization. Exp Eye Res 118, 80-88.
     
  • Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou KK, Schonewille M, Zhou HB, Velazquez-Perez L, Rodriguez-Labrada R, Villegas A, Ferrer I, Lopera F, Langer T, De Zeeuw CI, and Glatzel M (2014). Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest 124, 1552-1567.
     
  • Steculorum SM, and Brüning JC (2014). Die another day: A painless path to longevity. Cell 157, 1004-1006.
     
  • Steculorum SM, Solas M, and Brüning JC (2014). The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimers Dement 10, S3-11.
     
  • Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Odenthal M, and Thevis M (2014). Obesity resistance and deregulation of lipogenesis in delta6-fatty acid desaturase (fads2) deficiency. EMBO Rep 15, 110-120.
     
  • Storbeck M, Hupperich K, Gaspar JA, Meganathan K, Martinez Carrera L, Wirth R, Sachinidis A, and Wirth B (2014). Neuronal-specific deficiency of the splicing factor tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PLoS One 9, e89020.
     
  • Sturmer R, Müller S, Hanisch FG, and Hoffmann W (2014). Porcine gastric tff2 is a mucus constituent and differs from pancreatic tff2. Cell Physiol Biochem 33, 895-904.
     
  • Su Z, Fang H, Hong H, Shi L, Zhang W, Zhang W, Zhang Y, Dong Z, Lancashire LJ, Bessarabova M, Yang X, Ning B, Gong B, Meehan J, Xu J, Ge W, Perkins R, Fischer M, Tong W (2014). An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era. Genome Biol 15, 523.
     
  • Su ZQ, Labaj PP, Li S, Thierry-Mieg J, Thierry-Mieg D, Shi W, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD, Xiao WH, Xu WH, Jensen RV, Kelly R, Xu J, Conesa A, Furlanello C, Gao HL, Hong HX, Jafari N, Letovsky S, Liao Y, Lu F, Oakeley EJ, Peng ZY, Praul CA, Santoyo-Lopez J, Scherer A, Shi T, Smyth GK, Staedtler F, Sykacek P, Tan XX, Thompson EA, Vandesompele J, Wang MD, Wang J, Wolfinger RD, Zavadil J, Auerbach SS, Bao WJ, Binder H, Blomquist T, Brilliant MH, Bushel PR, Cain WM, Catalano JG, Chang CW, Chen T, Chen G, Chen R, Chierici M, Chu TM, Clevert DA, Deng YP, Derti A, Devanarayan V, Dong ZR, Dopazo J, Du TT, Fang H, Fang YX, Fasold M, Fernandez A, Fischer M, Furio-Tari P, Fuscoe JC, Caimet F, Gaj S, Gandara J, Gao H, Ge WG, Gondo Y, Gong BS, Gong MH, Gong ZL, Green B, Guo C, Guo L, Guo LW, Hadfield J, Hellemans J, Hochreiter S, Jia MW, Jian M, Johnson CD, Kay S, Kleinjans J, Lababidi S, Levy S, Li QZ, Li L, Li L, Li P, Li Y, Li HQ, Li JY, Li SY, Lin SM, Lopez FJ, Lu X, Luo H, Ma XW, Meehan J, Megherbi DB, Mei N, Mu B, Ning BT, Pandey A, Perez-Florido J, Perkins RG, Peters R, Phan JH, Pirooznia M, Qian F, Qing T, Rainbow L, Rocca-Serra P, Sambourg L, Sansone SA, Schwartz S, Shah R, Shen J, Smith TM, Stegle O, Stralis-Pavese N, Stupka E, Suzuki Y, Szkotnicki LT, Tinning M, Tu BM, van Deft J, Vela-Boza A, Venturini E, Walker SJ, Wan LQ, Wang W, Wang JH, Wang J, Wieben ED, Willey JC, Wu PY, Xuan J, Yang Y, Ye Z, Yin Y, Yu Y, Yuan YC, Zhang J, Zhang KK, Zhang WQ, Zhang WW, Zhang YY, Zhao C, Zheng YT, Zhou YM, Zumbo P, Tong WD, Kreil DP, Mason CE, and Shi LM (2014). A comprehensive assessment of rna-seq accuracy, reproducibility and information content by the sequencing quality control consortium. Nat Biotechnol 32, 903-914.
     
  • Sur I, Neumann S, and Noegel AA (2014). Nesprin-1 role in DNA damage response. Nucleus 5, 173-191.
     
  • Swaminathan K, Müller-Taubenberger A, Faix J, Rivero F, and Noegel AA (2014). A cdc42- and rac-interactive binding (crib) domain mediates functions of coronin. Proc Natl Acad Sci USA 111, E25-33.
     
  • Synofzik M, Martinez-Carrera LA, Lindig T, Schols L, and Wirth B (2014). Dominant spinal muscular atrophy due to bicd2: A novel mutation refines the phenotype. J Neurol Neurosur Ps 85, 590-592.
     
  • Tagliavini F, Pellegrini C, Sardone F, Squarzoni S, Paulsson M, Wagener R, Gualandi F, Trabanelli C, Ferlini A, Merlini L, Santi S, Maraldi NM, Faldini C, and Sabatelli P (2014). Defective collagen VI alpha6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies. Biochim Biophys Acta 1842, 1604-12.
     
  • Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, Lariviere WB, Schermer B, Pei YP, Torres VE, and Weimbs T (2014). The cleaved cytoplasmic tail of polycystin-1 regulates src-dependent stat3 activation. J Am Soc Nephrol 25, 1737-48.
     
  • Tatsuta T, Scharwey M, and Langer T (2014). Mitochondrial lipid trafficking. Trends Cell Biol 24, 44-52.
     
  • Textor A, Listopad JJ, Wuhrmann LL, Perez C, Kruschinski A, Chmielewski M, Abken H, Blankenstein T, and Charo J (2014). Efficacy of car t-cell therapy in large tumors relies upon stromal targeting by ifngamma. Cancer Res 74, 6796-805.
     
  • Trachtman H, Benzing T, Sever S, Harris RC, and Reiser J (2014). The grand challenge of nephrology. Frontiers in medicine 1, 28.
     
  • Troilo H, Zuk AV, Tunnicliffe RB, Wohl AP, Berry R, Collins RF, Jowitt TA, Sengle G, and Baldock C (2014). Nanoscale structure of the bmp antagonist chordin supports cooperative bmp binding. Proc Natl Acad Sci U S A 111, 13063-13068.
     
  • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Bronneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Bluher M, Krönke M, and Brüning JC (2014). Obesity-induced cers6-dependent c16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20, 678-686.
     
  • Voelkl J, Alesutan I, Pakladok T, Viereck R, Feger M, Mia S, Schonberger T, Noegel AA, Gawaz M, and Lang F (2014). Annexin a7 deficiency potentiates cardiac nfat activity promoting hypertrophic signaling. Biochem Bioph Res Co 445, 244-249.
     
  • Vogt A, Sievers E, Lukacs-Kornek V, Decker G, Raskopf E, Meumann N, Büning H, Sauerbruch T, Strassburg CP, Schmidt-Wolf IGH, and Gonzalez-Carmona MA (2014). Improving immunotherapy of hepatocellular carcinoma (hcc) using dendritic cells (dc) engineered to express Il-12 in vivo. Liver Int 34, 447-461.
     
  • Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, and Brüning JC (2014). Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell 156, 495-509.
     
  • von Tresckow B, Boell B, Eichenauer D, Beschorner D, Knop S, Goebeler ME, Chemnitz JM, Hallek M, Engert A, and Huebel K (2014). Anti-epidermal growth factor receptor antibody cetuximab in refractory or relapsed multiple myeloma: A phase ii prospective clinical trial. Leuk Lymph 55, 695-697.
     
  • Vorhagen S, and Niessen CM (2014). Mammalian apkc/par polarity complex mediated regulation of epithelial division orientation and cell fate. Exp Res 328, 296-302.
     
  • Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wustefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, and Eilers M (2014). Activation and repression by oncogenic myc shape tumour-specific gene expression profiles. Nature 511, 483-487.
     
  • Willenborg S, and Eming SA (2014). Macrophages - sensors and effectors coordinating skin damage and repair. J Dtsch Dermatol Ges 12, 214-221, 214-223.
     
  • Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, and Eming SA (2014). Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis. J Invest Dermatol 134, 2005-2015.
     
  • Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, and Gillingwater TH (2014). Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy. J Clin Invest 124, 1821-1834.
     
  • Wittwer T, Rahmanian P, Choi YH, Zeriouh M, Karavidic S, Neef K, Christmann A, Piatkowski T, Schnapper A, Ochs M, Muhlfeld C, and Wahlers T (2014). Mesenchymal stem cell pretreatment of non-heart-beating-donors in experimental lung transplantation. J Cardiothorac Surg 9, 151.
     
  • Zemva J, and Schubert M (2014). The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of alzheimer's disease: Possible therapeutic implications. Cns Neurol Disord-Dr 13, 322-337.
     
  • Zeriouh M, Sabashnikov A, Choi YH, Fatullayev J, Reuter H, Popov AF, Langebartels G, Kimmig L, Rahmanian PB, Wittwer T, Neef K, Wippermann J, and Wahlers T (2014). A novel treatment strategy of new onset atrial fibrillation after cardiac surgery: An observational prospective study. J Cardiothorac Surg 9, 83.
     
  • Zheng X, Gooi LM, Wason A, Gabriel E, Mehrjardi NZ, Yang Q, Zhang X, Debec A, Basiri ML, Avidor-Reiss T, Pozniakovsky A, Poser I, Saric T, Hyman AA, Li H, and Gopalakrishnan J (2014). Conserved tcp domain of sas-4/cpap is essential for pericentriolar material tethering during centrosome biogenesis. Proc Natl Acad Sci U S A 111, E354-363.
     
  • Zirkel A, and Papantonis A (2014). Transcription as a force partitioning the eukaryotic genome. Biol Chem 395, 1301-1305.
     
  • Zou YQ, Zwolanek D, Izu YY, Gandhy S, Schreiber G, Brockmann K, Devoto M, Tian ZZ, Hu Y, Veit G, Meier M, Stetefeld J, Hicks D, Straub V, Voermans NC, Birk DE, Barton ER, Koch M, and Bonnemann CG (2014). Recessive and dominant mutations in col12a1 cause a novel eds/myopathy overlap syndrome in humans and mice. Hum Mol Genet 23, 2339-2352.
     
  • Zwolanek D, Veit G, Eble JA, Gullberg D, Ruggiero F, Heino J, Meier M, Stetefeld J, and Koch M (2014). Collagen XXII binds to collagen-binding integrins via the novel motifs glqger and gfkger. Biochem J 459, 217-227.