Center for Molecular Medicine Cologne


Oct. 15, 2017 - Sunday

12.50 p.m.

Welcome Address

Thomas Benzing    Chair - Center for Molecular Medicine Cologne

Sabine Werner - Sabine Eming - Catherin Niemann - Thomas Krieg 
Scientific coordinators - Ernst Klenk Symposium 2017

Session I:
Exploring molecular concepts of cell renewal and stem cell function in tissue maintenance and repair

Chairs: Sabine Werner (ETH Zurich, CH) / Matthias Hammerschmidt - (Inst. for Zoology, Cologne, DE)

1.00 - 1.30 p.m.

Live imaging good and bad aspects of the wound inflammatory response
Paul Martin
Dept. of Physiology & Biochemistry, School of Medical Sciences, University of Bristol - Bristol, UK

1.30 - 2.00 p.m.

Reprogramming epigenetic memory in regeneration and cancer
Renato Paro
Dept. of Biosystems Science and Engineering - ETH Zurich and Faculty of Science, University of Basel - Basel CH

2.00 - 2.30 p.m.

From planarians to parasites: stem cells and developmental plasticity in flatworms
Phillip A Newmark
Howard Hughes Medical Institute and Morgridge Institute for Research, University of Wisconsin-Madison - Madison, US

2.30 - 3.00 p.m.

Chairs: Catherin Niemann (CMMC, Cologne, DE) / Alvaro Rada-Iglesias (CMMC, Cologne, DE)

Coffee Break

3.00 - 3.30 p.m.

Stem cells and epithelial homeostasis in mammary gland development
Ian G Macara
Dept. of Cell and Developmental Biology, Vanderbilt University School of Medicine - Nashville, US

3.30 - 4.00 p.m.

Exploring stem cell fate regulation through synthetic extracellular matrices
Matthias P Lutolf
Lab. of Stem Cell Bioengineering
, Institute of Chemical Sciences and Engineering, School of Basic Science, École Polytechnique Fédérale de Lausanne - Lausanne, CH

4.00 - 4.30 p.m.

Vascular control of liver development and function
Hellmut Augustin
Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ) - Heidelberg, DE

4.30 - 5.00 p.m.

Coffee Break

5.00 - 8.30 p.m.

Poster Session - Klenk Symposium 2017
combined with the Welcome Get-Together (free finger food and drinks)

5.30 - 6.30 p.m.: Poster Presentation A, C and D
6.30 - 7.30 p.m.: Poster Presentation B
7.30 - 8.30 p.m.: on-going discussions

Poster Award
The Klenk Poster Award 2017 of the Center for Molecular Medicine Cologne (CMMC) will be awarded to the presenting first author of the three most outstanding poster contributions. The awardees are invited to give a short presentation (10 min.) during the last session on Tuesday, Oct. 17, 2017 of the Klenk Symposium 2017.

Oct. 17, 2017 - Tuesday

Oct. 16, 2017 - Monday

Session IV:
Challenges and perspectives for translating scientific discoveries in regenerative medicine

Chairs: Carien Niessen (Dept. of Dermatology, CECAD, Cologne, DE) / Claus Cursiefen (Dept. of Ophthalmology, Cologne, DE)

9.00 - 9.30 a.m.

Cell and tissue therapy. Advances in science and practice
Robert S Kirsner
Dept. of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine - Miami, US

9.30 - 10.00 a.m.

Developing induced pluripotent stem (iPS) cell-based therapy for inherited skin diseases
Dennis R Roop
Dept. of Dermatology, University of Colorado Anschutz Medical Campus and Charles C. Gates Center for Regenerative Medicine, University  of Colorado Anschutz Medical Campus - Aurora, US

10.00 - 10.30 a.m.

GPS: Navigating the pathway for regenerative therapy
Robert Sackstein
Dept. of Dermatology, and Harvard Skin Disease Research Center, 
Brigham and Women's Hospital and 
Harvard Medical School - Boston, US

10.30 - 11.00 a.m.

Chairs: Thomas Benzing (CMMC Chair, Cologne, DE) / Björn Schumacher (CECAD, Cologne, DE)

Coffee Break

11.00 - 11.30 a.m.

Tumor associated macrophages: From mechanism to therapy
Jeffrey W Pollard
MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh - Edinburgh, UK

11.30 - 12.00 p.m.

Regenerating the damaged heart by stimulating cardiomyocyte proliferation
Jeroen Bakkers
Dept. of Cardiac Development and Genetics, Hubrecht Institute, University Medical Centre Utrecht
 - Utrecht, NL

12.00 - 12.30 p.m.

CRISPR-Cas9 genome editing, from mechanism to therapy
Jacob E Corn
Dept. of Molecular and Cell Biology and Innovative Genomics Institute, University of California - Berkeley, US

12.30 - 1.00 p.m.

Short presentation
by the four poster awardees (4 x 8 min. short talk)

Plasticity, convergence and legacy of Lgr5 and Lgr6 stem cells during cutaneous wound repair

Tina Jacobs
RG Maria Kasper - Center for Innovative Medicine & Dept. of Biosciences and Nutrition, Karolinska Institute - Stockholm, SE

Tissue-specific roles of FGF signaling during zebrafish caudal fin regeneration
Christopher Jahn 

RG Gilbert Weidinger - Insttute of Biochemistry & Molecular Biology, Ulm University - Ulm, DE

C-05: Comprehensive identification of wound healing and inflammation miRNAs reveals a key role for miR-223 in neutro-philic clearance of Staphylococcus aureus at wound sites

Ryoichi Mori
Department of Pathology, Nagasaki Univ. School of Medicine - Nagasaki, JP

B-25: Fibroblast secretion of TGF1 is executed by secretory autophagy
Julian Nüchel
RG Markus Plomann with cooperatin partners - Institute for Biochemistry II, Univ. of Cologne - Cologne, DE

1.00 - 1.15 p.m.

Summary, open questions, concluding remarks
Sabine Werner - Sabine Eming - Catherin Niemann - Thomas Krieg

Session II:
Mechanisms of cellular communication in tissue regeneration, repair and fibrosis

Chairs: Beate Eckes (Dept. of Dermatology, Cologne, DE) / Gerhard Sengle (Inst. for Biochemistry II, Cologne, DE)

9.00 - 9.30 a.m.

Scar Wars: fibroblast lineages and fibrosis
Michael T Longaker
Hagey Laboratory for Pediatric Regenerative Medicine and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine - Stanford, US

9.30 - 10.00 a.m.

Mechanotransduction and cell-matrix interaction regulates collective cell migration
Joachim P Spatz
Dept. of Cellular Biophysics, Max-Planck-Institute for Medical Research and
 Dept. of Biophysical Chemistry, University of Heidelberg - Heidelberg, DE

10.00 - 10.30 a.m.

Muscle stem cell regenerative decline with aging
Pura Munoz-Canoves
Dept. of Experimental and Health Science, ICREA and Pompeu Fabra University - Barcelona, ES

10.30 - 11.00 a.m.

Chairs: Cornelia Mauch (Dept. of Dermatology, Cologne, DE) / Reinhard Büttner (Inst. for Pathology, Cologne, DE)

Coffee Break

11.00 - 11.30 a.m.

Do fibroblast growth factors regulate fibrosis?
David M Ornitz
Dept. of Developmental Biology, Washington University School of Medicine - St. Louis, US

11.30 - 12.00 p.m.

p53 at the junction of tissue regeneration and cancer
Raffaella Sordella
Cold Spring Harbor Laboratory - Cold Spring Harbor, US

12.00 - 12.30 p.m.

Multistep cancer stromal cell activation and evolution
Gian-Paolo Dotto
Dept. of Biochemistry, University of Lausanne - Epalinges, CH and Cutaneous Biology Research Center, Massachusetts General Hospital - Charlestown, US

12.30 - 2.00 p.m.

Lunch Break (soup and sandwiches for all participants at the venue)

Session III:
New strategies of targeting the immune response in tissue remodeling

Chairs: Martin Krönke (CMMC Vice Chair, Cologne, DE) / Sabine Eming (Dept. of Dermatology, Cologne, DE)

2.00 - 2.30 p.m.

Type 2 immunity in tissue regeneration and fibrosis
Thomas A Wynn
Immunopathogenesis Section, Lab. of Parasitic Diseases
, National Institute of Allergy and Infectious Diseases, National Institute of Health - Bethesda, US

2.30 - 3.00 p.m

Immune cell-adipose tissue interactions during infection
Edward J Pearce
Dept. of Immunometabolism, Max-Planck-Institut für Immunbiologie und Epigenetik and Faculty of Biology, University of Freiburg - Freiburg, DE

3.00 - 3.30 p.m

Imaging the role of innate immunity in tissue repair
Paul Kubes
Snyder Institute for Chronic Diseases, University of Calgary - Calgary, CA

3.30 - 3.50 p.m.

Chairs: Manolis Pasparakis (Institute for Genetics, CECAD, Cologne, DE) / Hamid Kashkar (Institute for Med. Microbiology, Hygiene and Immunology, Cologne, DE)

Coffee Break

3.50 - 4.00 p.m.

Announcement of the awardees "Klenk Symposium Poster Award"

Tina Jacobs
(Stockholm, SE)
Plasticity, convergence and legacy of Lgr5 and Lgr6 stem cells during cutaneous wound repair

S. Joost, Tina Jacob, X. Sun, M. Kasper (Karolinska Institute, Stockholm, SE)

Chrisopher Jahn (Ulm, DE)
Tissue-specific roles of FGF signaling during zebrafish caudal fin regeneration
Christopher Jahn, D. Wehner, G. Weidinger 

(Inst. of Biochemistry & Molecular Biology, Ulm Univ. Ulm, DE)

Ryoichi Mori (Nagasaki, JP)C-05: Comprehensive identification of wound healing and inflammation miRNAs reveals a key role for miR-223 in neutro-philic clearance of Staphylococcus aureus at wound sites
 (Dept. of Pathology, Nagasaki University School of Medicine, JP)

Julian Nüchel (Cologne, DE) - Poster B 25
B-25: Fibroblast secretion of TGF1 is executed by secretory autophagy
Julian Nüchel1, S. Ghatak2, A. Zuk1, M. Mörgelin3, T. Krieg2,4,5, G. Sengle1,4, B. Eckes2, M. Plomann1 (1Biochemistry II and 2Dermatology, Univ. of Cologne, 3Division of Infection Medicine, Lund Univ., SE, 4CMMC and CECAD, Univ. of Cologne, DE)

4.00 - 4.30 p.m.

Development of hepatoprotective and pro-regenerative strategies: learning from nature
Matias A Avila
Hepatology Programme, Center for Applied Medical Research (CIMA), University of Navarra - Pamplona, ES

4.30 - 5.00 p.m.

Immune Strategies for accelerating regeneration
Nadia A Rosenthal
The Jackson Laboratory - Bar Harbor, US and Australian Regenerative Medicine Institute, Monash University - Melbourne, AU

5.00 - 5.30 p.m.

On the role of the immune system in supporting and fighting liver damage and liver cancer
Mathias Heikenwälder
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ) - Heidelberg, DE

5.30 - 6.00 p.m.

Coffee Break

6.00 - 7.00 p.m.
Ernst Klenk Lecture

Laudation: Thomas Krieg

How to control your neighbor – stromal epithelial cross-talk in tissue repair and inflammatory disease
Sabine Werner
Dept. of Biology, Institute for Molecular Health Sciences, ETH Zurich - Zürich, CH

General Information


Childcare is provided by Spielland, University Hospital Cologne.
Please contact for further information: klenk-symposium[at]

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We gratefully acknowledge support by

Program Klenk 2017

Poster Klenk 2017

Registration - Klenk Symposium 2017

Registration and participation in the Ernst Klenk Symposium 2017 is free of charge!
Free registration is required.

Please register:


For questions releated to your registration / travel and hotel information / requesting child care - please contact:

Tanja Bertenburg (CMMC Admin. Assistant)

Bettina Kranz (CMMC Admin. Assistant)