Center for Molecular Medicine Cologne

Dec. 08, 2016 - Thursday

Dec. 10, 2016 - Saturday

Dec. 09, 2016 - Friday

12.50 p.m.

Welcome Address

Thomas Krieg        Dean - Medical Faculty, University of Cologne
Michael Hallek       Chair - Center for Integrated Oncology
Thomas Benzing    Chair - Center for Molecular Medicine Cologne

Charles Swanton - Christian Reinhardt - Roman Thomas
Scientific coordinators - Ernst Klenk Symposium 2016

Session I:
Discovering basic principles of actionable genomic aberrations in cancer/tumor evolution/acquired resistance

Chair: Charles Swanton - London, UK / Michal-Ruth Schweiger - Cologne, DE

1.00 - 1.30 p.m.

Molecular targets in childhood malignancies
Stefan Pfister

German Research Cancer Center - Heidelberg, DE

1.30 - 2.00 p.m.

A landscape of pharmacogenomic interaction in cancer
Mathew Garnett

Wellcome Trust Sanger Institute - Cambridge, UK

2.00 - 2.30 p.m.

Targeted therapy of BRAF-nonV600 mutant melanoma: Lots of ideas, not much evidence
Jeffrey A Sosman

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA

2.30 - 3.00 p.m.

Chair: Martin Sos - Cologne, DE

Coffee Break

3.00 - 3.30 p.m.

Therapy of lymphoma inspired by functional and structural genomics
Louis M Staudt

Center for Cancer Research, National Institutes of Health - Bethesda, USA

3.30 - 4.00 p.m.

to be announced
Matthew L Meyerson
Dana-Farber Cancer Institute, Harvard Medical School - Boston, USA

4.00 - 4.30 p.m.

The development of next generation cancer therapeutics
William R Sellers

Broad Institute and Dana-Farber Cancer Institute - Cambridge, USA

4.30 - 5.00 p.m.

Coffee Break

5.00 - 8.30 p.m.

Poster Session - Klenk Symposium 2016
combined with the Welcome Get-Together (free finger food and drinks)

5.30 - 6.30 p.m.: Poster Presentation A01 - A20 and B01 - B 10
6.30 - 7.30 p.m.: Poster Presentation C01 - C24
7.30 - 8.30 p.m.: on-going discussions

Poster Award
The Klenk Poster Award 2016 of the Center for Molecular Medicine Cologne (CMMC) will be awarded to the presenting first author of the three most outstanding poster contributions. The awardees are invited to give a short presentation (10 min.) during the last session on Friday, Dec. 10, 2016 of the Klenk Symposium 2016.

Session II:
Using mouse models as preclinical avatars for the development of precision cancer medicine

Chair: Christian Pallasch - Cologne, DE

9.00 - 9.30 a.m.

Mouse models of lung cancer: What do they teach us?
Anton Berns
Netherlands Cancer Institute - Amsterdam, NL

9.30 - 10.00 a.m.

The use of mouse lung cancer models for preclinical testing of novel targeted therapeutics
Kwok K Wong
Dana-Farber Cancer Institute, Harvard Medical School - Boston, USA

10.00 - 10.30 a.m.

Deconstructing the molecular genetics of human cancer and its therapeutic implications
Pier P Pandolfi
Division of Genetics, Beth Israel Deaconess Medical Center - Boston, USA

10.30 - 11.00 a.m.

Coffee Break

Chairs: Reinhardt Büttner, Martin Peifer - Cologne, DE

11.00 - 11.30 a.m.

Tailored animal models through in vivo genome editing
Lukas E Dow
Depts. of Medicine, Hematology and Medical Oncology, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine - New York, USA

11.30 - 12.00 p.m.

Modeling and targeting GI-cancer subtypes
Dieter Saur
II Med. Klinik und Poliklinik, Technische Univ. München - Munich, DE

12.00 - 12.30 p.m.

Mouse models of small cell lung cancer to identify novel therapeutic strategies
Julien Sage
Depts. of Pediatrics and Genetics, Standford University Medical Center - Stanford, USA

12.30 - 2.00 p.m.

Lunch Break (soup and sandwiches for all participants at the venue)

Session III:
Novel approaches for targeted intervention in solid tumors, lymphomas and leukemias

Chair: Jürgen Wolf - Cologne, DE

2.00 - 2.30 p.m.

Being precise on the EGRF pathway
Tony S K Mok
Dept. of Clinical Oncologyof Sciences, The Chinese Univ. of Hong Kong - Hong Kong, HK

2.30 - 3.00 p.m

Lessons from targeted therapy in leukaemia and lymphoma
John G Gribben
John Vane Cancer Centre, Barts Cancer Institute, Queen Mary Univ. of London - London, UK

3.00 - 3.30 p.m

Mechanisms of acquired resistance to third generation TKis
Enriqueta Felip
Institute of Oncology, Vall d'Hebron University Hospital - Barcelona, ES

3.30 - 3.50 p.m.

Coffee Break

Chair: Matthias Fischer - Cologne, DE

3.50 - 4.00 p.m.

Announcement of the awardees "Klenk Symposium Poster Award"

4.00 - 4.30 p.m.

Somatic alterations in non-small cell lung cancer genomes
Matthew L Meyerson
Dana-Farber Cancer Institute, Harvard Medical School - Boston, USA

4.30 - 5.00 p.m.

Exploiting good and bad senescence in cancer therapy
Clemens A Schmitt
Charité - Universitätsmedizin and Max-Celbrück-Center for Molecular Medicine - Berlin, DE

5.00 - 5.30 p.m.

Translation and precision: optimising melanoma care
Richard Marais
Cancer Research UK Manchester Institute, Univ. of Manchester - UK

5.30 - 6.00 p.m.

Coffee Break

6.00 - 7.00 p.m.
Ernst Klenk Lecture

Laudation: Christian Reinhardt and Roman Thomas

Tracking cancer evolution: TRACERx
Charles Swanton
The Francis Crick Institute - Cambridge, UK

Session IV:
Immune checkpoint blockade as a novel therapeutic approach

Chair: Michael von Bergwelt-Baildon - Cologne, DE

9.00 - 9.30 a.m.

Cellular plasticity and clonal dynamics in cancer immunotherapy
Michael Hölzel

Inst. of Clinical Chemistry and Clinical Pharmacology, University of Bonn - Bonn, GER

9.30 - 10.00 a.m.

Development and reversal of T cell exhaustion
E John Wherry

Dept. of Microbiology and Institute for Immunology, University of Pennsylvania - Philadelphia, USA

10.00 - 10.30 a.m.

PD-1 cancer immunotherapy
Gordon J Freeman

Dept. of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School - Boston, USA

10.30 - 11.00 a.m.

Coffee Break

Chair: Roland Ullrich - Cologne, DE

11.00 - 11.30 a.m.

Checkpoint blockade in Melanoma - what do we know?
Dirk Schadendorf

Dept.of Dermatology, Venerology and Allergology, University-Hospital - Essen, GER

11.30 - 12.00 p.m.

Single-agent beyond inhibitor checkpoint in cancer immunotherapy
William Pao

Oncology Translational Medicine, Roche Pharma Research and Early Development - Basel, CHE

12.00 - 12.30 p.m.

Resistance mechanisms in cancer immunotherapy
Thomas Tüting

Dept. of Dermatology, University Hospital - Magdeburg, GER

12.30 - 1.00 p.m.

Short presentation
of the three poster awardees (3 x 10 min. short talk)

1.00 - 1.15 p.m.

Summary, open questions, concluding remarks
Charles Swanton - Christian Reinhardt - Roman Thomas


General Information

Registration is closed.

Childcare is provided by Spielland, University Hospital Cologne.
Please contact for further information: klenk-symposium[at]

For directions please visit:

For a site map please visit:

Program Klenk 2016

Poster Klenk 2016

Program and Poster Abstract Book


Questions releated to your registration / travel and hotel information / requesting child care -
please contact:
Tanja Bertenburg (CMMC Admin. Assistant)

Questions releated to your poster abstract submission - please contact:
Bettina Kranz (CMMC Admin. Assistant)