Abstract
Tumor heterogeneity may account for Invasion and metastasis testicular germ cell tumors. In our previous work we have identified predictive signatures for metastasis as well as immune regulatory networks such as IL6 signalling differentially expressed on the invasive front of seminomas. Here we will further approach the heterogenous composition of the germ cell tumor microenvironment in an interdisciplinary research project which will combine spatial and whole genome assessments in TGCT for evaluation of metastatic disease and to exploit its mechanisms for therapeutic approaches.
Clinical and Medical Relevance
Tumor heterogeneity is a major challenge in cancer therapy accounting for development of resistance. In testicular germ cell tumors (TGCT), the majority of patients show good response to chemotherapy, but patients facing resistance still have a poor prognosis. Chemo-refractory disease remains an obstacle that cannot be overcome with targeted or immune therapy.
Project Related Publications
- Dieckmann KP, Radtke A, Geczi L, Matthies C, Anheuser P, Eckardt U, Sommer J, Zengerling F, Trenti E, Pichler R, Belz H, Zastrow S, Winter A, Melchior S, Hammel J, Kranz J, Bolten M, Krege S, Haben B, Loidl W, Ruf CG, Heinzelbecker J, Heidenreich A, Cremers JF, Oing C, Hermanns T, Fankhauser CD, Gillessen S, Reichegger H, Cathomas R, Pichler M, Hentrich M, Eredics K, Lorch A, Wülfing C, Peine S, Wosniok W, Bokemeyer C, Belge G. Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study. J Clin Oncol. 2019 Jun 1;37(16):1412-1423,
- Lossos C, Liu Y, Kolb KE, Christie AL, van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM. Mechanisms of lymphoma clearance induced by high-dose alkylating agents. Cancer Discov. 2019 Apr 30
- Busch L, Mougiakakos D, Büttner-Herold M, Müller MJ, Volmer DA, Bach C, Fabri M, Bittenbring JT, Neumann F, Boxhammer R, Nolting J, Bisht S, Böttcher M, Jitschin S, Hoffmann MH, Balzer H, Beier F, Gezer D, Dudziak D, Gelse K, Hennig FF, Pallasch CP, Spriewald B, Mackensen A, Bruns H. Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway. Leukemia. 2018 Nov;32(11):2445-2458. doi: 10.1038/s41375-018-0114-0. Epub 2018 Mar 28.
Publications 2021
- Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, Koningsbruggen-Rietschel SV, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dotsch J, and Alejandre Alcazar MA (2021). Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia. Eur Respir J. doi:10.1183/13993003.02248-2020.
- Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hovelmeyer N, Schafer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Buttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Bruning JC, Hallek M, Kruger M, Peifer M, Pallasch CP, and Wunderlich FT (2021). Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood137, 646-660. doi:10.1182/blood.2020005734.
- Meyer A, Yan S, Golumba-Nagy V, Esser RL, Barbarino V, Blakemore SJ, Rusyn L, Nikiforov A, Seeger-Nukpezah T, Grull H, Pallasch CP, and Kofler DM (2021). Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis. J Autoimmun124, 102726. doi:10.1016/j.jaut.2021.102726.
- Ucal M, Maurer C, Etschmaier V, Hamberger D, Grunbacher G, Togl L, Roosen MJ, Molcanyi M, Vorholt D, Hatay FF, Hescheler J, Pallasch C, Schafer U, and Patz S (2021). Inflammatory Pre-Conditioning of Adipose-Derived Stem Cells with Cerebrospinal Fluid from Traumatic Brain Injury Patients Alters the Immunomodulatory Potential of ADSC Secretomes. J Neurotrauma38, 2311-2322. doi:10.1089/neu.2020.7017.
Publications 2020
- Barbarino V, Henschke S, Blakemore SJ, Izquierdo E, Michalik M, Nickel N, Mollenkotte I, Vorholt D, Muller L, Brinker R, Fedorchenko O, Mikhael N, Seeger-Nukpezah T, Hallek M, and Pallasch CP (2020). Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2. Cancers (Basel)12. doi:10.3390/cancers12082303.
Prof. Dr. Christian P Pallasch
Clinic I of Internal Medicine
CMMC - PI - assoc. RG 15
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Clinic I of Internal Medicine
Joseph-Stelzmannstr. 26
50937 Cologne
Publications - Christian P Pallasch
Prof. Dr. Dr. Axel Heidenreich
Clinic and Polyclinic of Urology and Uro-Oncology
CMMC - Co-PI - assoc. RG 15
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Clinic and Polyclinic of Urology and Uro-Oncology
Kerpener Str. 62
50937 Cologne
Publications - Axel Heidenreich
PD Dr. Tim Nestler
Clinic and Polyclinic of Urology and Uro-Oncology
CMMC - Co-PI - assoc. RG 15
show more…
Clinic and Polyclinic of Urology and Uro-Oncology
Kerpener Str. 62
50937 Cologne