Alcazar, Miguel A Alejandre - assoc. RG 38
Netrin-1 as a new target to treat chronic lung disease: Identification of agonists and antagonists by artificial intelligence
Prof. Dr. Dr. Miguel A Alejandre Alcazar
Clinic for Pediatric and Adolescent Medicine
CMMC - PI - assoc. RG 38
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Clinic for Pediatric and Adolescent Medicine
Kerpener Str. 62
50937 Cologne
Introduction
For information about Prof. Alcazar's research and work, please visit the following page: Experimental pneumology
Publications generated during 1/2023-12/2025 with CMMC affiliation
2024 (up to June)
- Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alejandre Alcazar MA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, and Bock F (2024). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biol15. doi:10.1093/jmcb/mjad062.
- Jakwerth CA, Weckmann M, Illi S, Charles H, Zissler UM, Oelsner M, Guerth F, Omony J, Nemani SSP, Grychtol R, Dittrich AM, Skevaki C, Foth S, Weber S, Alejandre Alcazar MA, van Koningsbruggen-Rietschel S, Brock R, Blau S, Hansen G, Bahmer T, Rabe KF, Brinkmann F, Kopp MV, Chaker AM, Schaub B, von Mutius E, Schmidt-Weber CB, and Research ASGapotGCfL (2024). 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma. Am J Respir Crit Care Med209, 947-959. doi:10.1164/rccm.202305-0934OC.
- Jirmo AC, Albrecht M, Crnkovic S, Alejandre Alcazar MA. Editorial: Cellular and systemic interplay of metabolism and inflammation in the pathogenesis of lung diseases. Front Immunol. 2024 Jan 17;14:1352304. doi: 10.3389/fimmu.2023.1352304. PMID: 38299152; PMCID: PMC10827871.
- Nusken E, Appel S, Saschin L, Kuiper-Makris C, Oberholz L, Schomig C, Tauscher A, Dotsch J, Kribs A, Alejandre Alcazar MA, and Nusken KD (2024). Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae. Cells13. doi:10.3390/cells13060501.
2023
- Ferrari N, Schmidt N, Bae-Gartz I, Vohlen C, Alcazar MAA, Brockmeier K, Dotsch J, Mahabir E, and Joisten C (2023). Maternal Exercise during Pregnancy Impacts Motor Performance in 9-Year-Old Children: A Pilot Study. Children (Basel) 10. doi:10.3390/children10111797.
- Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, and Bock F (2023). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biol. doi:10.1093/jmcb/mjad062.
- Hirani DV, Thielen F, Mansouri S, Danopoulos S, Vohlen C, Haznedar-Karakaya P, Mohr J, Wilke R, Selle J, Grosch T, Mizik I, Odenthal M, Alvira CM, Kuiper-Makris C, Pryhuber GS, Pallasch C, van Koningsbruggen-Rietschel S, Al-Alam D, Seeger W, Savai R, Dotsch J, and AlejandreAlcazar MA (2023). CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. Inflamm Regen 43, 52. doi:10.1186/s41232-023-00301-6.
- Selle J, Bohl K, Hopker K, Wilke R, Dinger K, Kasper P, Abend B, Schermer B, Muller RU, Kurschat C, Nusken KD, Nusken E, Meyer D, Savai Pullamsetti S, Schumacher B, Dotsch J, and Alcazar MAA (2023). Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling. Int J Mol Sci 24. doi:10.3390/ijms24032508.