Prof. Dr. med. Paul T Brinkkötter - Curriculum Vitae

Education and professional career

2016: Board certification “Geriatrics”
2015: Venia legendi for Internal Medicine, University of Cologne
2015: Attending physician (Oberarzt)
2014: Board certification “Internal medicine and Nephrology”
2010: Venia legendi for Molecular Medicine, University of Cologne
2009: Postdoctoral Fellow and Junior Group Leader, NephroLab Cologne,  University of Cologne (Prof. Benzing)
2006 - 2008: Postdoctoral fellow (Prof. Shankland), University of Washington, Seattle, Washington/USA, Fellow of the German Research Foundation (DFG)
2003 – 2006: Residency in Medicine, University Hospital Mannheim

Awards, distinctions and professional activities

2015: Young Investigator Award, German Society of Nephrology  (Carl-Ludwig Preis)
2008: Poster award, 7th International Podocyte Conference (Toronto, Canada)
2007: 2. Place Young Investigator Award, 6th Annual Nephrology Young Investigators’ Forum (San Diego, USA)
2007: Scholarship by the German Research Foundation for Participation in the Lindau Meeting of Nobel Laureates
2001 - 2002: Scholarship of the German Academic Exchange Service
1996 - 2002: Scholar of the Konrad-Adenauer-Foundation

Selected publications

Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Höhne M, Späth MR, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT. A T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes. Kidney Int 2017 Jun;91(6):1510-1517.

Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT. Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT. Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol. 2016 May;186(5):1128-39.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC. AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell 2016 Mar 24;165(1):125-38.

Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Inhibition of insulin/IGF-1 receptor signalling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 2015 Feb 2.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram MP,Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter PT. Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics. 2014 Nov 25.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT*, Benzing T*. Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration Barrier. J Am Soc Nephrol. 2014 Feb 7. *shared senior authorship.

Brinkkoetter PT, Wu JS, Oshe T, Krofft RD, Pippin JW, Shankland SJ: p35 safeguards podocytes against apoptosis in vitro and in vivo. Kidney Int  2010, Apr;77(8):690-9.

Brinkkoetter PT, Olivier P, Wu JS, Henderson S, Krofft RD, Pippin JW, Hockenbery D, Roberts JM, Shankland SJ: Cyclin I activates Cdk5 and regulates  expression of Bcl-2 and Bcl-XL in post-mitotic mouse cells. J Clin Invest 2009, Sept 1.

Brinkkoetter PT, Holtgrefe S, van der Woude FJ, Yard BA. Angiotensin II type 1-receptor mediated changes in heparan sulfate proteoglycans in human SV40 transformed podocytes. J Am Soc Nephrol. 2004 Jan;15(1):33-40.