Prof. Dr. med. Jens C Brüning - Curriculum Vitae

Education and professional career

2017: Elected Member, Leopoldina, National Academy of Sciences
2017: Family Hansen Award, Bayer Science and Education Foundation
2017: Elected Member, Academy of Sciences and Arts, North Rhine-Westphalia
2017: ERC Advanced Grant
2013: Outstanding Scientific Achievement Award, American Diabetes Association (ADA)
2011: Director of the Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) at the University Hospital of Cologne
2011: Director of the Max-Planck-Institute for Metabolism Research, Cologne
2011: Elected Member EMBO
2009: Ernst Jung-Award for Medicine
2009 - 2011: Max-Planck Fellow of the Max-Planck-Institute for the Biology of Aging, Cologne
2008: Minkowski-Award of the European Association for the Study of Diabetes
2007: Coordinator of the Cologne Excellence Cluster ‘Cellular stress responses in aging-associated diseases (CECAD)’, University of Cologne
2007: Gottfried Wilhelm Leibniz Award of the DFG
2006 - 2008: Acting Director of the Institute for Genetics, University of Cologne
2006: Science Award of the Lesser Loewe Foundation
2005: Ferdinand-Bertram-Award 2005 of the German Diabetes-Society
2005: Science Award 2005 of the Wilhelm-Vaillant-Foundation
2003 - 2011: Tenured professor at the Institute for Genetics, University of Cologne Head of Department of Mouse Genetics and Metabolism
2002: ‘Venia legendi’ for Internal Medicine, University of Cologne
2001 - 2003: Attending physician, 2nd Department for Internal Medicine, University of Cologne
2001: Ernst and Berta Scharrer Award, German Society of Endocrinology (DGE)
2001: Board Exam in Internal Medicine
2001: Board Exam in Endocrinology
2000: 1. Prize Young Masters, German Society of Internal Medicine (DGIM)
1997 - 2001: Resident in Internal Medicine, University Hospital Cologne, and establishment of research group at the University of Cologne
1996 - 1997: Mary K. Iacocca Fellow at the Joslin Diabetes Center, Boston, USA
1995: Young Investigator Award, American Society of Internal Medicine
1994 - 1997: Post-doctoral Fellow, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA in the laboratory of Professor C. Ronald Kahn
1993: Thesis (Dr. med.) at the Klinik I für Innere Medizin, University of Cologne, Head: Prof. Volker Diehl, MD
1992 - 1994: Resident in Internal Medicine, 2nd Department for Internal Medicine, University of Cologne
1985 - 1992: Medical School, University of Cologne

Selected publications

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25;166(5):1338-1340. doi: 10.1016/j.cell.2016.08.010. PubMed PMID: 27565353.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC. AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell. 2016 Mar 24;165(1):125-38. doi: 10.1016/j.cell.2016.02.044. PubMed PMID: 27015310; PubMed Central PMCID: PMC5157157.

Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC. Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons. Cell. 2015 Sep 10;162(6):1404-17. doi: 10.1016/j.cell.2015.08.032. PubMed PMID: 26359991.

Vogt MC, Paeger L, Hess S, Steculorum, SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL and Bruning JC. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell. 2014,
156(3): 495-509.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Bronneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Bluher M, Kronke M and Bruning JC. Obesity-induced CerS6-dependent C16:0 ceramide production promotes
weight gain and glucose intolerance. Cell Metab. 2014, 20(4): 678-686.

Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, C. Hausen A, Schmitz J, Bronneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT and Bruning JC. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014, 15(5): 423-430.

Tovar S, Paeger L, Hess S, Morgan DA, Hausen AC, Bronneke HS, Hampel B, Ackermann PJ, Evers N, Buning H, Wunderlich FT, Rahmouni K, Kloppenburg P and Bruning JC. KATP-Channel-Dependent Regulation of Catecholaminergic Neurons Controls BAT Sympathetic Nerve Activity and Energy Homeostasis. Cell Metab. 2013, 18(3): 445-455.

Kornfeld JW, Baitzel C, Konner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M and Bruning JC. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature. 2013, 494(7435): 111-115.

Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Bronneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Ruther U, Jaffrey SR, Kloppenburg P and Bruning JC.The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013, 16(8): 1042-1048.

Rother E, Belgardt BF, Tsaousidou E, Hampel B, Waisman A, Myers Jr MG and Bruning JC. Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature.Proc Natl Acad Sci USA. 2012, 109(44): 18132-18137.

Klockener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P and Bruning JC. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci. 2011, 14(7): 911-918.

Jordan SD, Kruger M, Willmes DM, Redemann N, Wunderlich FT, Bronneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Bottger T, Braun T, Seibler J and Bruning JC. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 2011, 13(4): 434-446.

Konner AC, Hess S, Tovar S, Mesaros A, Sanchez-Lasheras C, Evers N, Verhagen LA, Bronneke HS, Kleinridders A, Hampel B, Kloppenburg P and Bruning JC. Role for insulin signaling in atecholaminergic neurons in control of energy homeostasis. Cell Metab. 2011, 13(6): 720-728.