PD Dr. rer. nat. Gerhard Sengle - Curriculum Vitae

Education and professional career

2013: Habilitation: Biochemistry and Molecular Biology, University of Cologne
since 2011: Independent group leader, Center for Biochemistry, Faculty of Medicine, University of Cologne
2009 - 2011: Senior Research Associate, Oregon Health & Science University, Portland, OR, USA
2003 - 2009: Post-doctoral fellow, Shriners Hospital for Children, Portland, OR, USA
2002 - 2003: Postdoctoral Fellow, Medical Faculty, Center for Biochemistry, University of Cologne
2001: Alternative Civilian Service (“Zivildienst”), Medical Faculty, Center for Biochemistry, University of Cologne
2001: Doctorate: Dr. rer. nat., Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn
1998: Diploma in Chemistry/ Biochemistry, LMU Munich

Awards, distinctions and professional activities

2017: Chair, Annual Meeting of the German Society for Matrix Biology
2016 - present: Board, International Society of Matrix Biology (ISMB)
2014 - present: Board, treasurer, German Society for Matrix Biology (DGMB)
2004 - 2006: DFG Research Fellowship

Selected publications

Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G. Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts. Sci Rep. (2017) in press.

Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G. Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models. Acta Biomater. (2017) 52: 41-48.

Wohl AP, Troilo H, Zuk AV, Collins R, Baldock C, Sengle G. Extracellular regulation of BMP activity by the microfibril component fibrillin-1. J Biol Chem. (2016) 291: 12732-46.

Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G. Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J Invest Dermatol. (2016) 136: 1150-1160.

Sengle G, Carlberg V, Tufa SF, Charbonneau NL, Smaldone S, Carlson EJ, Ramirez F, Keene DR, Sakai LY. Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. PLoS Genet. (2015) 11: e1005340.

Sengle G, Tsutsui K, Keene DR, Tufa SF, Carlson EJ, Charbonneau NL, Ono RN,     Sasaki T, Wirtz MK, Samples JR, Fessler LI, Fessler JH, Sekiguchi K, Hayflick SJ, Sakai LY. Microenvironmental regulation by fibrillin-1. PLoS Genet (2012) 8: e1002425.

Sengle G, Ono RN, Sasaki T, Sakai LY. Prodomains of transforming growth factor beta     (TGFbeta) superfamily members specify different functions: extracellular matrix nteractions and growth factor bioavailability. J Biol Chem (2011) 286: 5087-99.

Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol (2008) 381: 1025-39.

Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bächinger HP, Sakai LY. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem (2008) 283: 13874-88.