Prof. Dr. rer. nat. Carien M Niessen - Curriculum Vitae

Education and professional career
Since 2015     International Medical and Scientific Advisory Panel of DEBRA (Dystrophic Epidermolysis Bullosa Association)
Since 2015     Chair, Collaborative Research Center SFB 829
Since 2014     Head ‘Cologne Graduate School for Aeging Biology’
Since 2014     Vice president German Society for Cell Biology
Since 2009     Scientific Coordinator Collaborative Research Center SFB 829
2008 - 2013     Board member ‘European Society for Dermatological Research’
2008 - 2012     W2-Professor, Krebshilfe
Since 2008     Professor of Dermato-oncology, University of Cologne
Since 2007     Scientific head CECAD Research Platform B 'Education and Career development, Gender equality and Public Outreach’
2006     ROSA 'Research on Skin Dryness’ award
2002 - 2007     Independent Group Leader, Center for Molecular Medicine Cologne
1997 - 2001     Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Centre, New York, NY (Laboratory of Dr. B.M. Gumbiner, Cellular Biochemistry and Biophysics)
1999 - 2001     Fellowship Charles A. Dana Foundation
1997 - 1998     Fellowship Dutch Cancer Society
1996     Postdoctoral Fellow The Netherlands Cancer Institute, Amsterdam, The Netherlands (Laboratory of Dr. A. Sonnenberg, Division of Cell Biology)
1991 - 1996     PhD studies 'Graduate School for Oncology’, Netherlands Cancer Institute
1984 - 1991     Studies in Biology, University of Utrecht, The Netherlands

Selected publications
Peters F, Vorhagen S, Brodesser S, Jacobshagen K, Brüning JC, Niessen CM*, Krönke M*. Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. J Invest Dermatol. 2015, 135:1501-9. *Shared corresponding author.

Guenschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Bruning JC and Niessen CM. IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Developmental Cell. 2013, 26(2):176-87.

Niessen MT, Scott J, Zielinski J, Vorhagen S, Blanpain C, Leitges M and Niessen CM. aPKC? controls epidermal homeostasis and stem cell fate through regulation of division orientation. J Cell Biol. 2013, 202:887-900.

Mertz AF, Che Y, Banerjee S, Goldstein J, Rosowski KA, Revilla S, Niessen CM, Marchetti MC, Dufresne ER and Horsley V. Intercellular adhesions organize epithelial cell-matrix traction forces. Proc Natl Acad Sci USA. 2013, 110: 842-7.

Niessen CM, Leckband D and Yap AS. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol. Reviews. 2011, 91:691-731.

Weber S, Niessen MT ,Prox J, Luellmann-Rauch, Schmitz A., Schwanbeck R, Blobel CP, de Strooper B, Niessen CM* and Saftig P*. The disintegrin/metalloproteinase ADAM10 is essential for the Notch -mediated development and integrity of the epidermis. Development. 2011,138:495-505. *corresponding authors.

Garinis GA, Uittenboogaard LM, Stachelscheid H, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
Nat Cell Biol. 2009, 11:604-15.

Seifert K, Ibrahim H, Winklbauer R and Niessen CM. An adhesion independent, aPKC dependent function for cadherins in morphogenetic movements. J Cell Sci. 2009, 122: 2514-23.

Stachelscheid H*, Ibrahim H*, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Haase I, Wickenhauser C, Brüning J* Niessen CM*. Epidermal Insulin/IGF-1 signaling control interfollicular morphogenesis and proliferative potential via Rac activation. EMBO J. 2008, 27:2091-101. *corresponding authors.

Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T and Niessen CM. E-cadherin is essential for in vivo skin barrier function by regulating tight junctions. EMBO J. 2005, 24: 1146-1156.