Prof. Dr. rer. nat. Aleksandra Trifunovic - Curriculum Vitae

Education and professional career

since 2014: Professor of Mitochondrial Disease and Ageing
since 2010: Private Lecturer (Privatdozent), University of Cologne, Germany
2009 - 2014: Tenure tracked Junior Research Group Leader, CECAD Excellence Cluster, University of Cologne, Germany
2009 - 2012: Senior Scientist, Karolinska Institute, Stockholm, Sweden
2006 - 2009: Assistant Professor, Karolinska Institute, Stockholm, Sweden
2000 - 2005: Postdoctoral Fellow, Karolinska Institute, Stockholm, Sweden
1998 - 2000: PhD student, Institute of Molecular Genetics and Genetic Engineering - IMGGE, Belgrade University, Serbia
1994 - 1998: Graduate student, Institute of Molecular Genetics and Genetic Engineering IMGGE, Belgrade University, Serbia
1989 - 1994: Undergraduate Student, Faculty of Biological Sciences, Belgrade University, Serbia

Awards, distinctions and professional activities

since 2017: Associated Editor for Cell Stress
since 2016: Associated Editor for Translation Medicine of Ageing
since 2014: Regular Guest Editor for PLoS Genetics  
2015: Guest Editor for BBA Bioenergetics special issue “Mitochondrial Dysfunction in Ageing”
2014: Guest Editor for Experimental Gerontology special issue “Mitochondria. Metabolic Regulation and the Biology of Aging”
since 2013: Visiting Professor, Medical Faculty, Belgrade University, Serbia
since 2012: Associated Editor Frontiers in Genetics
2010: Young Investigator award Jaensson Foundation

Selected publications

Szczepanowska K, Trifunovic A. Origins of mtDNA mutations in ageing. Essays Biochem. 2017 Jul 11;61(3):325-337.
Theisen BE, Rumyantseva A, Cohen JS, Alcaraz WA, Shinde DN, Tang S, Srivastava S, Pevsner J, Trifunovic A, Fatemi A. Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. Am J Med Genet A. 2017 Jun 26.
Szczepanowska K, Maiti P, Kukat A, Hofetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Kru¨ger M, Trifunovic. CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 2016 Oct 20.
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Kukat A, Trifunovic A (2016) Loss of ClpP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-964.
Rugarli E, Trifunovic A. Is mitochondrial free radical theory of aging getting old? Biochim Biophys Acta. 2015 Nov;1847(11):1345-6.

Szczepanowska K, Trifunovic A. Different faces of mitochondrial DNA mutators. Biochim Biophys Acta. 2015 Nov;1847(11):1362-72.
Belaidi AA, Röper J, Arjune S, Krizowski S, Trifunovic A, Schwarz G. Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency. Biochem J. 2015 Jul 15;469(2):211-21.
Li L, Trifunovic A, Köhler M, Wang Y, Petrovic Berglund J, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO. Defects in ß-cell Ca2+ dynamics in age-induced diabetes. Diabetes. 2014 Dec;63(12):4100-14. doi: 10.2337/db13-1855. Epub 2014 Jul 1.

Trifunovic A, Ventura N. Mitochondria and metabolic control of the aging process. Exp Gerontol. 2014 Aug;56:1-2.
Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A (2014) Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity. PLoS Genet 10: e1004385.

Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A (2014) Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab 19: 458-469.

Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A. Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant. PLoS One. 2013;8(3):e59493. doi: 10.1371/journal.pone.0059493. Epub 2013 Mar 28.

Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A (2012) Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab 15: 100-109.

Kukat A, Edgar D, Bratic I, Maiti P, Trifunovic A. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts. Biochem Biophys Res Commun. 2011 Jun 10;409(3):394-9.

Dogan SA, Trifunovic A. Modelling mitochondrial dysfunction in mice. Physiol Res. 2011;60 Suppl 1:S61-70.
Hench J, Bratic Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunovic A. A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. PLoS One. 2011;6(12):e28417. doi: 10.1371/journal.pone.0028417. Epub 2011 Dec 5.

Bratic I, Hench J, Trifunovic A. Caenorhabditis elegans as a model system for mtDNA replication defects. Methods. 2010 Aug;51(4):437-43.

Bratic I, Trifunovic A. Mitochondrial energy metabolism and ageing. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):961-7.

Edgar D, Larsson NG, Trifunovic A. Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse. Cell Metab. 2010 Jan;11(1):1. doi: 10.1016/j.cmet.2009.12.001. No abstract available.

Edgar D, Trifunovic A. The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging. Aging (Albany NY). 2009 Dec 11;1(12):1028-32.

Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans  L, Nedergaard J, Cannon B, Larsson NG,  Trifunovic A (2009) Random point mutations with major effects on protein coding genes drive premature ageing in mtDNA mutator mice. Cell Metab 10: 131-138.

Bratic I, Hench J, Henriksson J, Antebi A, Bürglin TR, Trifunovic A. Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development. Nucleic Acids Res. 2009 Apr;37(6):1817-28.
Kukat A, Trifunovic A. Somatic mtDNA mutations and aging--facts and fancies. Exp Gerontol. 2009 Jan-Feb;44(1-2):101-5.

Trifunovic A, Larsson NG. Mitochondrial dysfunction as a cause of ageing. J Intern Med. 2008 Feb;263(2):167-78. doi: 10.1111/j.1365-2796.2007.01905.x.

Stewart JB, Freyer C, Elson JL, Wredenberg A, Cansu Z, Trifunovic A, Larsson NG (2008) Purifying selection in transmission of mammalian mitochondrial DNA. PLoS Biol  6: e10.

Niu X, Trifunovic A, Larsson NG, Canlon B. Somatic mtDNA mutations cause progressive hearing loss in the mouse. Exp Cell Res. 2007 Nov 1;313(18):3924-34.
Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30. Epub 2007 Jan 16.