Prof. Dr. med. Thomas Langmann - Curriculum Vitae

Education and professional career

2016: Expert Advisor for German Research Program for Ophthalmology
2015: Nomination: Patent Award ‘ZukunftErfinden NRW’
2015: Vice speaker and deputy scientific coordinator DFG-Group FOR2240
2014: Patent Inventor: Polysialic acid use for treatment of neurodegenerative and Neuroinflammatory diseases. WO2014154537 A1
2014: Visionary of the Quarter nominated by the European Vision Institute
2012: Novartis EYENovative Ophthalmic Research Award
since 2012: W3-Professor and Director, Experimental Immunology of the Eye, University of Cologne
2010 - 2012: W2-Professor for Retinal Degeneration, Institute of Human Genetics, University of Regensburg
2006 - 2010: Group leader, Institute of Human Genetics, University of Regensburg
2006: Research Award, Foundation for Pathobiochemistry
2004 - 2006: Group leader, Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg
2004: Ivar-Trautschold-Award, German Society for Clin. Chem. and Lab. Med.
2004: 'Habilitation' in Biological Sciences, University of Regensburg
2000 - 2004: Senior Scientist, Institute for Clinical Chemistry and Laboratory Medicine at the University Hospital of Regensburg
1999 - 2000: DFG Postdoctoral fellowship, Harvard Institutes of Medicine, USA
1995 - 1998: PhD at the University of Regensburg
1990 - 1995: Study of Biology and Diploma at the University of Regensburg
1994: Oskar-Karl-Forster-Stipend for young gifted students

Selected publications

Lückoff A, Scholz R, Sennlaub F, Xu H, Langmann T. Comprehensive analysis of mouse retinal mononuclear phagocytes. Nat Protocols 2017, 12:1136-1150.

Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A,  Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T*, Neumann H*. Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation and protects from vascular damage in the retina. EMBO Mol Med. 2017, 9:154-166 *shared senior authors.

Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T. Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med. 2016; 8:670-8.

Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T. Retinal microglia: Just bystander or target for therapy? Prog Retin Eye Res. 2015 Mar;45C:30-57.

Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis K, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jägle H, Stoehr H, Wolfrum U, Langmann T. Disruption of the Retinitis Pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Hum Mol Genet. 2014, 23:5197-5210.

Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T. Translocator protein (18kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014, 11:3.

Karlstetter M, Lippe E, Walczak Y, Moehle C, Aslanidis A, Mirza M, Langmann T. Curcumin is a potent modulator of microglial gene expression and migration. J Neuroinflammation. 2011, 8:125.

Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T*, Weber BH*. The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. Hum Mol Genet. 2011, 20:1132-42.

Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response. J Immunol. 2010, 185:3379-3390.

Langmann T, Di Gioia SA, Rau I, Stohr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet. 2010, 87:376-381.

Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. Genome Res. 2010, 20:1512-1525.