Center for Molecular Medicine Cologne

Thomas, Roman - assoc. RG 22

Lung Cancer Genomics

Abstract

Our Lab Mission is to understand the impact of somatic genetic alterations in cancer cells on the highly complex regulatory network of signaling pathways.

To address these questions we take advantage of a wide range of genetic, molecular and genomic techniques as well as biostatistics and computational biology tools. Our group is composed of scientists with various background including biologists, clinicians and physicist to study functional, cell biology apsects of cancer genomics towards novel drug development.

  • Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Hohne MN, Stuker L, de Padua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, and von Karstedt S (2021). Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun12, 2048. doi:10.1038/s41467-021-22336-4.
                          • Bragelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Buttner R,Ullrich RT, Siveke JT, Ohashi K, Schlee M, and Sos ML (2021). MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun12, 5505. doi:10.1038/s41467-021-25728-8.
                                                                                                                                                                                                                                                                                                • Rosswog C, Bartenhagen C, Welte A, Kahlert Y, Hemstedt N, Lorenz W, Cartolano M, Ackermann S, Perner S, Vogel W, Altmuller J, Nurnberg P, Hertwig F, Gohring G, Lilienweiss E, Stutz AM, Korbel JO, Thomas RK, Peifer M, and Fischer M (2021). Chromothripsis followed by circular recombination drives oncogene amplification in human cancer. Nat Genet53, 1673-1685. doi:10.1038/s41588-021-00951-7.
                                                                                                                                                                                                                                                                                                          • Schaufler D, Ast DF, Tumbrink HL, Abedpour N, Maas L, Schwabe AE, Spille I, Lennartz S, Fassunke J, Aldea M, Besse B, Planchard D, Nogova L, Michels S, Kobe C, Persigehl T, Westphal T, Koleczko S, Fischer R, Weber JP, Altmuller J, Thomas RK, Merkelbach-Bruse S, Gautschi O, Mezquita L, Buttner R, Wolf J, Peifer M, Bragelmann J, Scheffler M, and Sos ML (2021). Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer. NPJ Precis Oncol5, 102. doi:10.1038/s41698-021-00241-9.
                                                                                                                                                                                                                                                                                                          Prof. Dr. Roman Thomas CMMC Cologne
                                                                                                                                                                                                                                                                                                          Prof. Dr. Roman Thomas

                                                                                                                                                                                                                                                                                                          Department of Translational Genomics

                                                                                                                                                                                                                                                                                                          CMMC - assoc. RG 22

                                                                                                                                                                                                                                                                                                          +49 221 478 98777

                                                                                                                                                                                                                                                                                                          +49 221 478 86465

                                                                                                                                                                                                                                                                                                          Department of Translational Genomics

                                                                                                                                                                                                                                                                                                          Weyertal 115b

                                                                                                                                                                                                                                                                                                          50931 Cologne

                                                                                                                                                                                                                                                                                                          http://www.translational-genomics.uni-koeln.de/

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                                                                                                                                                                                                                                                                                                          Curriculum Vitae (CV)

                                                                                                                                                                                                                                                                                                          Publications on PubMed

                                                                                                                                                                                                                                                                                                          Publications - Roman Thomas

                                                                                                                                                                                                                                                                                                          Link to PubMed