Loss of transcriptional control has been proposed as a causal link to cardiac ageing.
We discovered that DHS is a key molecular driver of age-associated cardiac episodes in humans by mediating the loss of transcriptional control.
A temporal decline in the functional and molecular integrity of an organism defines its ageing process. While multiple hallmarks of ageing have recently been enumerated, our understanding of their functional, molecular and temporal hierarchy remains incomplete.
The significance of these hallmarks in the ageing process vary in a tissue/ cell type specific manner. Considering the physiological differences between organs, it is conceivable that their susceptibility to these distinct triggers of ageing can differ.
Therefore, it is important to delineate those mechanisms that influence the ageing process of specific organs to better understand organismal ageing. We investigate evolutionarily conserved mechanisms that leads to aging of the heart.
We envision to
1. develop precise molecular understanding
2. test therapeutic targets to alleviate DHS-mediated cardiotoxicity
3. develop a preclinical serum based method for rapid, early detection of cardiac damage and ageing
Laboratory for Developmental and Regenerative RNA Biology - Dr. Leo Kurian
Center for Molecular Medicine Cologne | Institute for Neurophysiology | CMMC Research Building
CMMC - PI - A 07
CMMC - PI - assoc. JRG 01show more…
Aviseka Acharya (PhD student)
Deniz Bartsch (PostDoc)
Kalamkar Kaustubh (PhD student)
Arya Mesgary (PhD student)
Christoph Walter (Master student)
David Nelles (visiting scientist (Tartan LLC))