Center for Molecular Medicine Cologne

Christian P Pallasch | Axel Heidenreich | Tim Nestler - assoc. RG 15

Exploiting tumor heterogeneity and tumor microenvironment interactions in Testicular Germ Cell Tumors (TGCT) impacting metastasis and therapy response

Abstract

Tumor heterogeneity may account for Invasion and metastasis testicular germ cell tumors.

In our previous work we have identified predictive signatures for metastasis as well as immune regulatory networks such as IL6 signalling differentially expressed on the invasive front of seminomas.

Here we will further approach the heterogenous composition of the germ cell tumor microenvironment in an interdisciplinary research project which will combine spatial and whole genome assessments in TGCT for evaluation of metastatic disease and to exploit its mechanisms for therapeutic approaches.

Clinical and Medical Relevance

Tumor heterogeneity is a major challenge in cancer therapy accounting for development of resistance.

In testicular germ cell tumors (TGCT), the majority of patients show good response to chemotherapy, but patients facing resistance still have a poor prognosis.

Chemo-refractory disease remains an obstacle that cannot be overcome with targeted or immune therapy.

Project Related Publications

  1. Dieckmann KP, Radtke A, Geczi L, Matthies C, Anheuser P, Eckardt U, Sommer J, Zengerling F, Trenti E, Pichler R, Belz H, Zastrow S, Winter A, Melchior S, Hammel J, Kranz J, Bolten M, Krege S, Haben B, Loidl W, Ruf CG, Heinzelbecker J, Heidenreich A, Cremers JF, Oing C, Hermanns T, Fankhauser CD, Gillessen S, Reichegger H, Cathomas R, Pichler M, Hentrich M, Eredics K, Lorch A, Wülfing C, Peine S, Wosniok W, Bokemeyer C, Belge G. Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study. J Clin Oncol. 2019 Jun 1;37(16):1412-1423,
  2. Lossos C, Liu Y, Kolb KE, Christie AL, van Scoyk A, Prakadan SM, Shigemori K,  Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM. Mechanisms of lymphoma clearance induced by high-dose alkylating agents. Cancer Discov. 2019 Apr 30
  3. Busch L, Mougiakakos D, Büttner-Herold M, Müller MJ, Volmer DA, Bach C, Fabri  M, Bittenbring JT, Neumann F, Boxhammer R, Nolting J, Bisht S, Böttcher M, Jitschin S, Hoffmann MH, Balzer H, Beier F, Gezer D, Dudziak D, Gelse K, Hennig FF, Pallasch CP, Spriewald B, Mackensen A, Bruns H. Lenalidomide enhances MOR202-dependent macrophage-mediated effector
Prof. Dr. Christian P Pallasch CMMC Cologne
Prof. Dr. Christian P Pallasch

Clinic I of Internal Medicine / RG location - CECAD Building

CMMC - assoc. Research Group

 

+49 221 478 84128

+49 221 478 97295

Clinic I of Internal Medicine / RG location - CECAD Building

Joseph-Stelzmannstr. 26

50937 Cologne

CMMC Profile Page

Publications - Christian P Pallasch

Link to PubMed

Prof. Dr. Axel Heidenreich CMMC Cologne
Prof. Dr. Axel Heidenreich

Clinic and Polyclinic of Urology and Uro-Oncology / RG location - LFI Building

CMMC - assoc. Research Group

+49 221 478 82108

+49 221 478 86465

Clinic and Polyclinic of Urology and Uro-Oncology / RG location - LFI Building

Kerpener Str. 62

50937 Cologne

https://urologie.uk-koeln.de/informationen/ansprechpartner-auf-einen-blick/

CMMC Profile Page

Publications - Axel Heidenreich

Link to PubMed

Dr. Tim Nestler CMMC Cologne
Dr. Tim Nestler

Clinic and Polyclinic of Urology and Uro-Oncology / RG location - LFI Building

CMMC - assoc. Research Group

+49 221 478 76747

Clinic and Polyclinic of Urology and Uro-Oncology / RG location - LFI Building

Kerpener Str. 62

50937 Cologne

CMMC Profile Page

Publications on PubMed

Publications - Tim Nestler

Linkt to PubMed