Center for Molecular Medicine Cologne

Pallasch, Christian P | Heidenreich, Axel | Nestler, Tim - assoc. RG 15

Exploiting tumor heterogeneity and tumor microenvironment interactions in Testicular Germ Cell Tumors (TGCT) impacting metastasis and therapy response

Abstract

Tumor heterogeneity may account for Invasion and metastasis testicular germ cell tumors.

In our previous work we have identified predictive signatures for metastasis as well as immune regulatory networks such as IL6 signalling differentially expressed on the invasive front of seminomas.

Here we will further approach the heterogenous composition of the germ cell tumor microenvironment in an interdisciplinary research project which will combine spatial and whole genome assessments in TGCT for evaluation of metastatic disease and to exploit its mechanisms for therapeutic approaches.

Clinical and Medical Relevance

Tumor heterogeneity is a major challenge in cancer therapy accounting for development of resistance.

In testicular germ cell tumors (TGCT), the majority of patients show good response to chemotherapy, but patients facing resistance still have a poor prognosis.

Chemo-refractory disease remains an obstacle that cannot be overcome with targeted or immune therapy.

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                                                                                                                  • Meyer A, Yan S, Golumba-Nagy V, Esser RL, Barbarino V, Blakemore SJ, Rusyn L, Nikiforov A, Seeger-Nukpezah T, Grull H, Pallasch CP, and Kofler DM (2021). Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis. J Autoimmun124, 102726. doi:10.1016/j.jaut.2021.102726.
                                                                                                                                                                                                                                                                    • Ucal M, Maurer C, Etschmaier V, Hamberger D, Grunbacher G, Togl L, Roosen MJ, Molcanyi M, Vorholt D, Hatay FF, Hescheler J, Pallasch C, Schafer U, and Patz S (2021). Inflammatory Pre-Conditioning of Adipose-Derived Stem Cells with Cerebrospinal Fluid from Traumatic Brain Injury Patients Alters the Immunomodulatory Potential of ADSC Secretomes. J Neurotrauma38, 2311-2322. doi:10.1089/neu.2020.7017.
                                                                                                                                                                                                                                                                    • Barbarino V, Henschke S, Blakemore SJ, Izquierdo E, Michalik M, Nickel N, Mollenkotte I, Vorholt D, Muller L, Brinker R, Fedorchenko O, Mikhael N, Seeger-Nukpezah T, Hallek M, and Pallasch CP (2020). Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2. Cancers (Basel)12. doi:10.3390/cancers12082303.
                                                                                                                                                                                                                                                                    Prof. Dr. Christian P Pallasch CMMC Cologne
                                                                                                                                                                                                                                                                    Prof. Dr. Christian P Pallasch

                                                                                                                                                                                                                                                                    Clinic I of Internal Medicine

                                                                                                                                                                                                                                                                    CMMC - PI - assoc. RG 15

                                                                                                                                                                                                                                                                     

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                                                                                                                                                                                                                                                                    Prof. Dr. Axel Heidenreich CMMC Cologne
                                                                                                                                                                                                                                                                    Prof. Dr. Axel Heidenreich

                                                                                                                                                                                                                                                                    Clinic and Polyclinic of Urology and Uro-Oncology

                                                                                                                                                                                                                                                                    CMMC - Co-PI - assoc. RG 15

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                                                                                                                                                                                                                                                                    PD Dr. Tim Nestler CMMC Cologne
                                                                                                                                                                                                                                                                    PD Dr. Tim Nestler

                                                                                                                                                                                                                                                                    Clinic and Polyclinic of Urology and Uro-Oncology

                                                                                                                                                                                                                                                                    CMMC - Co-PI - assoc. RG 15

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                                                                                                                                                                                                                                                                    Clinic and Polyclinic of Urology and Uro-Oncology

                                                                                                                                                                                                                                                                    Kerpener Str. 62

                                                                                                                                                                                                                                                                    50937 Cologne

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                                                                                                                                                                                                                                                                    Curriculum Vitae (CV)

                                                                                                                                                                                                                                                                    Publications on PubMed

                                                                                                                                                                                                                                                                    Publications - Tim Nestler

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