Prof. Dr. rer. nat. Margarete Odenthal - Curriculum Vitae

Education and professional career

2015: apl. Professor
2007: Venia Legendi for Experimental and Molecular Pathology
since 2011: Head of the Laboratory of Translational Research at the Institute for Pathology (University Hospital of Cologne)
2002 - 2010: Head of the Laboratory of Molecular Diagnostics at the Institute for Pathology (University Hospital of Cologne)
1999 - 2002: Member of the managing board of the Santron AG (Electronic devices of hybridisation arrays for novel diagnostic approaches)
1996 - 2002: Research associate at the Institute for Pathology (University of Cologne)
1992: Scientific stay at the Dept. of Cell Biology at the University of Brussels, Belgium
1990 - 1996: Research associate at the I. Medical Department and the Institute for Pathology at the University of Mainz
1990: Dr.rer.nat. graduate (PhD) at the Georg-August-University of  Göttingen
1987 - 1989: Research fellow at the Dept. of Biochemistry, University of Stockholm (Sweden), supported by German Research Foundation (DFG)  and the German Academic Exchange Service (DAAD)
1985 - 1990: PhD-thesis work at the Institute for Plant Physiology of the University of Göttingen (Germany) and  the Arrhenius Laboratory, University of Stockholm (Sweden)
1979 - 1985: Studies in Biology (Diploma) at the University of Göttingen and Gießen

Awards, distinctions and professional activities

2011: Member of the European Association of Cancer Research (EACR)
2009: Member German Association for Pathology  (DGP) e.V.
2008: Member oft the German Liver Foundation
2007: Member of the European Association for the Study of the Liver (EASL)
2002: Innovation Award of Cologne: Fet sensor with a specially configured gate electrode for the highly sensitive detection of analytes (Patent application of M. Goryll, H. Lüth, J. Moers, M. Odenthal, and A. Offenhäusser: WO 2003056322)
2000: Award of North Rhine Westphalia for the Patent (WO 2002004509 A3): Gene expression, genome alteration and reporter expression in myofibroblasts and myofibroblast-like cells.
1991: Member of the German Association fort the Study of the Liver (GASL)

Selected publications

Lévy PL, Duponchel S, Eischeid H, Molle J, Michelet M, Diserens G, Vermathen M, Vermathen P, Dufour JF, Dienes HP, Steffen HM, Odenthal M, Zoulim F, Bartosch B. Hepatitis C virus infection triggers a tumor-like glutamine metabolism. Hepatology 65(3):789-803; (2017).

Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R. Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer. Gut. 65(8):1296-305; (2016).

Weseslindtner L, Macheleidt I, Eischeid H, Strassl R, Hofer H, Popow-Kraupp T, Dienes HP, Holzmann H, and Odenthal M. Micro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy. Liver Int. 36, 353-60; (2016).

Brault C, Levy P, Duponchel S, Michelet M, Salle A, Pecheur EI, Plissonnier ML, Parent R, Vericel E, Ivanov AV, Demir M, Steffen HM, Odenthal M, Zoulim F, and Bartosch B. Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity. Gut 65, 144-54; (2016).
Anadol E, Schierwagen R, Elfimova N, Tack K, Schwarze-Zander C, Eischeid H, Noetel A, Boesecke C, Odenthal M*, and Trebicka J. Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients. Hepatology 61: 46-55; (2015) *equally contributed senior author.
Odenthal M, Hee J, Gockel I, Sisic L, Schmitz J, Stoecklein NH, Driemel C, Mohlendick B, Schmidt T, Knoefel WT, Lang H, Buttner R, Ott K, and Vallbohmer D. Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Int J Cancer 137, 230-7; (2015).

Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, et al. and Knolle PA. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol. 14, 574-83; (2013).

Odenthal M, Bollschweiler E, Grimminger PP, Schroder W, Brabender J, Drebber U, Holscher AH, Metzger R, and Vallbohmer D. MicroRNA profiling in locally advanced esophageal cancer indicates a high potential of miR-192 in prediction of multimodality therapy response. Int J Cancer 133, 2454-2463; (2013).

Noetel A, Elfimova N, Altmuller J, Becker C, Becker D, Lahr W, Nurnberg P, Wasmuth H, Teufel A, Buttner R, Dienes HP and Odenthal M. Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells. J Hepatol. 58, 335-41; (2013).

Elfimova N, Sievers E, Eischeid H, Kwiecinski M, Noetel A, Hunt H, Becker D, Frommolt P, Quasdorff M, Steffen HM, Nurnberg P, Buttner R, et al. and Odenthal M. Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration. Biochim Biophys Acta. Mol. Cell Res.1833, 1190-8; (2013).

Trebicka J, Anadol E, Elfimova N, Strack I, Roggendorf M, Viazov S, Wedemeyer I, Drebber U, Rockstroh J, Sauerbruch T, Dienes HP and Odenthal M. Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis. J Hepatol. 58: 234-9; (2013).

Varnholt H, Drebber U, Schulze F, Wedemeyer I, Schirmacher P, Dienes HP and Odenthal M. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47,1223-1232; (2008).