The CMMC research areas

The three CMMC research areas enhance and strengthen innovative molecular research with clinical reference

The CMMC fosters interdisciplinary collaboration from the laboratory to the clinic as well as offers an exceptional training ground for the next generation of scientists and clinicians having a strong interest in and firm commitment to biomedical research. The research projects supported by the different funding programs are grouped within three CMMC core research areas:

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Reinhard Büttner / Margarete Odenthal - A 1

The multifaceted function of the lysine-specific histone demethylase 1 in lung cancer

Christiane Bruns - assoc. RG

Relevance of the IL-17 immune response in a mouse model of pancreatic cancer and its modulation with mesenchymal stem cells

Mathieu Clement-Ziza - assoc. RG

Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

Alexander Drzezga - assoc. RG

CXCR4 in kidney tumors

Matthias Fischer - A 2

The functional and therapeutic significance of activated telomerase in neuroblastoma

Jay Gopalakrishnan - assoc. RG

Targeting centrosome activation mechanisms to perturb cancer cell proliferation and invasion

Michael Hallek / Phoung-Hien Nguyen - A 3

Comprehensive analyses of the mechanistic role of LYN kinase in B cell malignancies

Matthias Hammerschmidt - A 4

The multiple facets of the type II transmembrane serine protease ST14 and hypotonic stress during carcinogenesis in fish and mammals

Robert Haensel-Hertsch - JRG X

Epi(Genome) structure and stability

Marco Herling / Elena Vasyutina - A 5

Context-specific mechanisms of the TCL1 oncogene in T- and B-cell leukemias

Roman-Ulrich Müller - assoc. RG

Characterizing the molecular functions of the tumor suppressor protein Folliculin using the model organism Caenorhabditis elegans

Sandra Iden - A 6

Requirement of polarity networks in melanoma cell plasticity, therapy and drug resistance

Axel Heidenreich - assoc. RG

Molecular mechanisms involved in migration, invasion and metastastic processes of testicular germ cell tumors

Catherin Niemann - A 7

Mechanisms of stem cell-specific gatekeeper functions in cancer initiation

Maria Notara - CAP 15

Effects of UV irradiation on corneal angiogenic privilege: pterygium as a UV-induced stem cell disease model: The limbal niche and corneal avascularity

Christian P Pallasch - CAP 5

Functional implications and interaction of macrophages in the tumor microenvironment upon genotoxic stress

Manolis Pasparakis - A 8

Immunogenic properties of necroptosis and apoptosis in stimulating anti-tumor immunity

Martin Peifer / H Christian Reinhardt - A 9

Exploring actionable cooperating lesions that drive Myd88-mediated lymphomagenesis

Martin Peifer - CAP 6

Computational cancer genomics

Simon Poepsel - JRG XI

Structure and biochemistry of epigenetic regulators

Stephan Rosenkranz - CAP 7

Role of PI3Kd in atherosclerosis

Michal-Ruth Schweiger - A 10

Epigenetic mechanisms of genomic instability and therapy resistance in cancer

Martin Sos - A 11

Genomic and molecular characterization of the evolutionary process of drug resistance in EGFR-mutant lung cancer

Roman Thomas - assoc. RG

Lung Cancer Genomics

Mirka Uhlirova - A 12

Cutting through the tumor complexity: Role of splicing in epithelial homeostasis and tumorigenesis

Roland Ullrich - CAP 9

Targeting tumor angiogenesis

Michael von Bergwelt-Baildon - assoc. RG

Function of B cells in tertiary lymphoid structures in pancreatic tumors

Research Area B: Principles of immunity, inflammation and infection

Stephan Baldus / Martin Mollenhauer / Volker Rudolph - B 2

Inflammatory pathways propagating ventricular tachycardia - the role of myeloperoxidase for postischemic pro-arrhythmic remodeling

Oliver A Cornely - assoc. RG

Antigen reactive CD69+/CD154+/CD4+ T Cells for Cell mediated Immunity in Infectious Diseases - TCI – ID

Claus Cursiefen / Felix Bock / Deniz Hos - B 3

Novel therapeutic role of myeloid cell-derived VEGF-C and lymphangiogenesis in resolution of corneal inflammation and reestablishment of corneal transparency

Ludwig Eichinger - assoc. RG

Functional analysis of p97/VCP and its interaction partners

Mario Fabri - assoc. RG

Glucocorticoid regulation of cutaneous Th17 host responses

Jan Herter - CAP 13

CD4 T cell reactivation in peripheral tissues

Deniz Hos - CAP 11

The contribution of myeloid cells to corneal neovascular disease

Hamid Kashkar - B 4

The role of mitochondrial apoptosis in macrophages and macrophage-derived tumor-promoting inflammation

Florian Klein - assoc. RG

Antibody-mediated therapy and prevention of infectious pathogens

Thomas Langmann - assoc. RG

Modulation of microglia as novel therapy concept for blinding diseases

Helmar Lehmann - CAP 3

Mechanisms of axonal injury in neuroinflammation and neurotoxicity

Argyris Papantonis - assoc. RG

Towards a structure-to-function code for mammalian genomes

Hans A Schlößer - CAP 12

Tumor-specific endogenous immune response and immune escape in gastrointestinal Cancer

Björn Schumacher / Ashley Williams - B 5

Chronic inflammatory responses to persistent cytoplasmic DNA

Esther von Stebut-Borschitz - assoc. RG

Skin immune defense mechanisms against cutaneous leishmaniasis

Olaf Utermöhlen - assoc. RG

Pathogenicity of Zika Virus strains in various host cell types

Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration

Miguel A Alejandre Alcazar - CAP 10

Pursuing novel molecular mechanisms and treatment strategies in bronchopulmonary dysplasia: functional role of Krüppel-like factor 4 (Klf4)

Bodo Beck / Janine Altmüller - C 1

Rare renal disorders identify core aspects of renal homeostasis - an integral approach to discover fundamental molecular principles of the kidney

Thomas Benzing / Matthias Hackl - C 2

The role of slit diaphragm signalling of podocytes

Matteo Bergami - C 3

Role of astrocytes in microvasculature remodeling following brain injury

Andreas Beyer / Argyris Papantonis - C 4

Contribution of deteriorating RNA biosynthesis to cellular ageing

Paul T Brinkkötter - C 5

Mitochondrial energetics and its contribution to podocyte function

Paul T Brinkkötter - CAP 1

Mitochondrial dysfunction and glomerular disease

Jens C Brüning - C 6

Fto-dependent regulation of hypothalamic neurons

Sebahattin Cirak - assoc. JRG II

Primary Muscle Disease

Martin S Denzel - assoc. RG

Metabolic and genetic regulation of Aging

Sabine Eming / Maria Leptin - C 7

The role of TOR pathway components in skin function

Mafalda Escobar-Henriques - CAP 14

Role of mitofusin 2 in health and disease

Dirk Isbrandt / Maria A Rüger / Michael Schroeter / Igor Jakovcevski - C 8

Novel roles for HCN/h- and Kv7/M-currents in the development of the cerebral cortex

Leo Kurian - assoc. JRG I

Developmental and regenerative RNA biology

Thomas Langer - C 9

Impaired mitochondrial proteostasis in CLPB associated disease

Carien M Niessen - C 10

Regulation of cell and tissue architecture in skin homeostasis, regeneration and degeneration

Angelika A Noegel / Peter Nürnberg - C 11

Role of Wnt signaling in the etiology of Filippi syndrome and ectrodactyly ectodermal dysplasia

Alvaro Rada-Iglesias - assoc. RG

Developmental Genomics: Transcriptional regulation in development and disease

Jan Rybniker - CAP 8

Comprehensive host-cell based antibiotic drug discovery

Bernhard Schermer / Max C Liebau - C 12

The role of the cilia-cell-cycle connection in tissue homeostasis of renal tubular epithelium in acute and chronic kidney diseases

Guenter Schwarz - C 13

Sulfite oxidase-dependent nitric oxide synthesis: Molecular mechanism, in vivo relevance and pharmacological targeting

Gerhard Sengle / Raimund Wagener / Mats Paulsson - C 14

Extracellular microfibrillar systems in disease pathogenesis: functional interactions in cytokine regulation, cellular differentiation and tissue homeostasis

Wilhelm Stoffel - SRG 1

Antagonistic pleiotropy of the Δ6-fatty acid desaturase (fads2) gene in disease and senescence. ω3- and ω6-Polyunsaturated fatty acids in Δ6-fatty acid desaturase (fads2-/-) deficiency

Aleksandra Trifunovic - C 15

Manipulation of CLPP protease to complement mitochondrial respiratory deficiency

Rudolf J. Wiesner - assoc. RG

Maintenance of mtDNA integrity in muscle stem cells

Brunhilde Wirth - C 16

Unraveling the molecular and cellular mechanism underlying spinal muscular atrophy by use of genetic modifiers

Completed Projects