Former Funding Period 01/2023 – 12/2025
Information from this funding period will not be updated anymore. New research related information is available here.
Research Area A
- Bazzi, Hisham - A 01
The mitotic surveillance pathway in stem cells - Bergami, Matteo | Motori, Elisa - A 02
Role of synaptic hijacking in SCLC brain metastatic growth - Büttner, Reinhard | Kondylis, Evangelos - A 03
Systematic mapping of the p62-KEAP1-NRF2 axis and co-regulated pathways across human cancers - Fischer, Matthias - A 04
Elucidating the mechanisms of spontaneous regression and differentiation in neuroblastoma using genetically engineered mouse models - Frenzel, Lukas | Hallek, Michael - A 05
The dialogue of CLL cells with the tumor microenvironment as a mediator of treatment resistance against targeted inhibitor combinations - Hillmer, Axel | Büttner, Reinhard - A 06
Identification of therapeutic vulnerabilities of KEAP1-mutated lung adenocarcinoma - von Karstedt, Silvia - A 07
Targeting the Necroptosis Pathway in Pancreatic Cancer - Kurian, Leo - A 08
Engineering mRNA translation specialization modules to ameliorate pathological cardiac hypertrophy: from pathomechanisms to clinical targets, and off-the-shelf therapeutic strategies - Nguyen, Phuong-Hien | Renata Stripecke | Alessandro Annibaldi - A 09
Understanding the multifaceted regulation of T cell immunity in B cell lymphoma for improved immunotherapy - Schumacher, Björn - A 10
Bypassing hotspot mutated p53 - Wunderlich, Thomas - A 11
The crosstalk between marginal zone B cells and female hormonal state in the development of benign liver cancer
Research Area B
- Brinkkötter, Paul | Brähler, Sebastian - B 01
Inflammatory signaling in the PDSS2-model of metabolic podocyte damage – from mouse models to human biopsy analysis - Cabreiro, Filipe | Corrado, Mauro | Solagna, Francesca - B 02
Role of gut microbiota on the onset of sarcopenia - Corrado, Mauro - B 03
Epigenetic-metabolic crosstalk in the development of T cell immunological memory - Cursiefen, Claus | Hadrian, Karina | Hos, Deniz - B 04
Targeting the osmosensitive transcription factor NFAT5 in acute and chronic corneal edema - Jantsch, Jonathan - B 05
Endothelial cells and pericytes in cutaneous leishmaniasis - Kashkar, Hamid - B 06
Role of IAPs in TNF-induced vasculature alteration and their therapeutic value in inflammatory diseases - Langmann, Thomas | Wolf, Anne - B 07
Retinal microglia and their immunological effects in AAV-based ocular gene therapy - Maier, Berenike | Higgins, Paul - B 08
Correlating biofilm structure with antibiotic tolerance - Pasparakis, Manolis - B 09
Role of autophagy in the regulation of ZBP1-mediated cell death and inflammation - Rybniker, Jan | Theobald, Sebastian - B 10
Deciphering and modulating innate and adaptive immune crosstalk in SARS-CoV-2 vaccination - Trifunovic, Aleksandra - B 11
Role of mitochondria in the regulation of innate immunity responses - Winkels, Holger | Mollenhauer, Martin - B 12
Olfr2-mediated macrophage activation in obesity induced endothelial dysfunction
Research Area C
- Benzing, Thomas - C 01
Pressure-dependent proteostasis regulation in podocytes at the kidney filtration barrier and the pathogenesis of albuminuria - Beyer, Andreas | Hänsel-Hertsch, Robert - C 02
Detecting transcriptional mistakes of RNA Polymerase-II at the single-cell level - Brüning, Jens C - C 03
Identification and characterization of the specific subpopulation of prepronociceptin (PNOC)-expressing neurons responsible for the development of diet-induced obesity - Eming, Sabine | Fabri, Mario - C 04
Unlocking tissue protective and regenerative functions of myeloid cells by metabolic reprograming - Gehring, Niels - C 05
Function of nonsense-mediated mRNA decay in brain development and neurological disease - Hammerschmidt, Matthias - C 06
Novel pathomechanisms of spine abnormalities and intervertebral disc degeneration caused by mutations in the fatty acid synthase gene - Hoppe, Thorsten - C 07
Understanding the pathomechanism of spinocerebellar ataxia caused by inherited mutations in the ubiquitin ligase CHIP - Kononenko, Natalia - C 08
Dissecting the role of Alzheimer’s disease-associated endocytosis risk factors in regulating cell cycle events in neuronal cells - Korotkova, Tatiana | Schaefer, Anne - C 09
Regulation of neuronal activity, cognitive and social functions by microglia in health and pathology - Lemberg, Marius | Schiavinato, Alvise | Nüchel, Julian - C 10
Triaging of secretory cargo by interplay of TANGO1 and ERAD-R - Liebau, Max C | Schermer, Bernhard - C 11
Understanding the mechanisms underlying early kidney failure in ARPKD - Niessen, Carien M | Hanßen, Ruth - C 12
Skin insulin resistance in type II diabetes and its associated diseases - Rosenkranz, Stephan | Vantler, Marius - C 13
Role of TNF-mediated inflammatory signaling in heart failure with preserved ejection fraction (HFpEF) and associated pulmonary hypertension (PH) - Rugarli, Elena I - C 14
Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways - Schwarz, Günter - C 15
Development of treatments for molybdenum cofactor and sulfite oxidase deficiency - Vilchez, David - C 16
Correction of alterations in the ubiquitinated proteome to prevent age-related neurodegenerative diseases - Vogt, Johannes | Kepser, Lara-Jane - C 17
Bioactive lipid signaling in adult neurogenesis and metabolic modulation - Wirth, Brunhilde | Piano, Valentina - C 18
Vesicular trafficking and axonal local translation in health and motor neuron disease
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