Center for Molecular Medicine Cologne

Funding Period 01/2020 - 12/2022

Research Area A: Mechanisms of tumor development: intrinsic and extrinsic control of cell proliferation and tissue invasion

A 01 - Reinhard Büttner | Maria Anokhina | Margarete Odenthal

Institute for Pathology
Epigenetic impact on reprogramming of alternative splicing in cancer

A 02 - Mafalda Escobar-Henriques1 | Margarete Odenthal2

1Institute for Genetics - 2Institute for Pathology
The role of MFN2 in CMT2A neurodegeneration and in NAFLD liver disease

A 03 - Matthias Fischer

Department of Experimental Pediatric Oncology
The role of MAP2K7 inactivation in malignant transformation of neuroblastoma

A 04 - Michael Hallek | Phuong-Hien Nguyen | Rocio Rebollido-Rios

Department I of Internal Medicine
Understanding the impact of the lymphoid microenvironment in B cell malignancies by single-cell analysis

A 05 - Matthias Hammerschmidt

Institute for Zoology
The double faces of ST14, Notch signaling and p53, and the impact of cell competition, entosis and apical cell extrusion during carcinogenesis and tumor suppression

A 06 - Silvia von Karstedt

Department of Translational Genomics
Elucidation of ferroptosis-inducing therapy (FIT) for the treatment of pancreatic cancer

A 07 - Leo Kurian

Institute for Neurophysiology
Early detection and epigenetic rejuvenation strategies for age-associated cardiac dysfunctions in humans

A 08 - Carien M Niessen

Department of Dermatology
Epithelial-stromal crosstalk and cell fate regulation in field cancerization

A 09 - Maria Notara | Claus Cursiefen

Department of Ophthalmology
The role and therapeutic potential of autophagy-related mechanisms in UV-induced blinding ocular stem cell disorders (Pterygium)

A 10 - Ron Jachimowicz

Department I of Internal Medicine
Exploring the efficacy of PARP1 inhibition and anti-PD1 treatment for UBQLN4-overexpressing KRAS-driven lung adenocarcinoma

A 11 - Björn Schumacher

Institute for Genome Stability in Ageing and Disease
Translational control of the p53 response in hair follicle stem cells

A 12 - Michal-Ruth Schweiger1 | Simon Pöpsel2 | Jens Klußmann3

1Department of Epigenetics and Tumor Genetics - 2CMMC - 3Department of Otorhinolaryngology, Head and Neck Surgery
The structure of the BRD4 stress complex and implications in HPV maintenance and therapy response

A 13 - Martin Sos

Institute for Pathology
Exploring epigenetic drivers of EMT during therapeutic stress in lung cancer

 

Reasearch Area B: Principles of immunity, inflammation and infection
 

B 01 - Paul T Brinkkötter | Sebastian Brähler

Department II of Internal Medicine
Metabolic reprogramming of renal immune cells in a model of glomerulonephritis

B 02 - Grit Herter-Sprie1 | Jan Herter2 | Roland Ullrich1

1Department I of Internal Medicine - 2Department of Radiation Oncology
Mechanism of the “Abscopal Effect” upon Radiation Therapy (RT)

B 03 - Sandra Iden

CECAD Research Center
Tissue-scale control of epidermal immunity by polarity networks in homeostasis and disease

B 04 - Hamid Kashkar

Institute for Medical Microbiology, Immunology and Hygiene
The role of caspase-8 in B cell development and lymphomagenesis

B 05 - Thomas Langmann | Khalid Rashid

Department of Ophthalmology
Microglia modulation as target for diabetic retinopathy

B 06 - Berenike Maier1 | Paul Higgins2

1Institute for Biological Physics - 2Institute for Medical Microbiology, Immunology and Hygiene
Correlating biofilm structure with antibiotic tolerance

B 07 - Manolis Pasparakis

Institute for Genetics
The role of FADD and caspase-8 in the regulation of intestinal epithelial cell death and inflammation

B 08 - Esther von Stebut-Borschitz | Nir Yogev

Department of Dermatology
The role of antigen-presenting cell subtypes in anti-Leishmania immunity

 

Research Area C: Molecular mechanisms and metabolic control of tissue degeneration and regeneration
 

C 01 - Miguel A Alejandre Alcazar1 | Manuel Koch2

1Department of Children and Adolescent Medicine - 2Institute for Oral and Musculoskeletal Biology
Netrin-1 as a new target to treat chronic lung disease: Identification of agonists and antagonists by artificial intelligence

C 02 - Thomas Benzing | Matthias Hackl

Department II of Internal Medicine
Cellular crosstalk of endothelial cells and podocytes in glomerular injury and repair

C 03 - Matteo Bergami

CECAD Research Center
The role of metabolic signaling at the glio-vascular interface during brain injury and repair

C 04 - Andreas Beyer

CECAD Research Center
Mechanisms of age-associated decline in splicing fidelity

C 05 - Jens C Brüning

Center for Clinical Endocrinology, Diabetology and Preventive Medicine
The role of prepronociceptin (PNOC)-expressing neurons in the development of obesity

C 06 - Sabine Eming

Department of Dermatology
Metabolic regulation of myeloid cells in tissue repair and regeneration

C 07 - Niels Gehring

Institute for Genetics
Molecular mechanism of X-linked intellectual disability caused by mutations in the UPF3B gene

C 08 - Thorsten Hoppe

Institute for Genetics
The role of UNC45B missense mutations in progressive congenital muscle disease

C 09 - Dirk Isbrandt | Andrea Merseburg

Institute for Molecular and Behavioral Neuroscience
Developmental-stage specific analysis of molecular disease mechanisms in genetic epileptic encephalopathies

C 10 - Tatiana Korotkova

Institute for Vegetative Physiology
Regulation of feeding in health and pathology by glucagon-like peptide-1 receptor-expressing cells in the lateral hypothalamus and the lateral septum

C 11 - Marcus Krüger

Institute for Genetics
Heart failure in pressure overload hypertrophy: The role of 111000E22RIK in ventricular remodeling and signaling

C 12 - Peter Nürnberg1 | Muhammad Sajid Hussain2

1Cologne Center for Genomics - 2Institute for Biochemistry I
Deciphering the role of C1orf131 – a novel nucleolar protein – in the etiology of intellectual disability and microcephaly

C 13 - Elena Rugarli

Institute for Genetics
Mapping hereditary spastic paraplegia: towards common pathogenic and novel rescue pathways

C 14 - Bernhard Schermer1 | Max C Liebau2

1Department II of Internal Medicine - 2Department of Children and Adolescent Medicine
Discovering novel diseases mechanisms of human ciliopathies using proximity labelling technologies

C 15 - Aleksandra Trifunovic | Karolina Szczepanowska

Institute for Mitochondrial Diseases and Ageing
Manipulation of CLPP protease to complement mitochondrial respiratory deficiency

C 16 - David Vilchez

CECAD Research Center
Defining modulators of RNA-binding protein aggregation for intervention of the neurodegenerative disease Amyotrophic Lateral Sclerosis

C 17 - Rudolf J Wiesner | Julia B Tarin

Institute for Vegetative Physiology
Maintenance of mitochondrial DNA integrity in epidermal keratinocytes during aging caused by internal and external insults

C 18 - Brunhilde Wirth

Institute for Human Genetics
Targeting CHP1, an SMN-independent pathway to counteract spinal muscular atrophy in mice and human iPSCs

C 19 - F Thomas Wunderlich

Center for Clinical Endocrinology, Diabetology and Preventive Medicine
Deciphering the crosstalk between Hippo and insulin signaling pathways in intestinal regeneration and maintenance of epithelial integrity during obesity