Center for Molecular Medicine Cologne

Prof. Dr. Jay Gopalakrishnan - Curriculum Vitae

Education and professional career

From July 2018: Univ.-Prof., Institute for Human Genetics, Division: Cellular models of genetic disorders, University Hospital, Düsseldorf Heinrich-Heine-University, Düsseldorf Head, Human organoids for aging and environmental medicine, IUF – Leibniz Research Institute for Environmental Medicine
2018: Steering committee member, Stem Cell Network North Rhine Westphalia
2013-2018: Principal Investigator, Laboratory for Centrosome and Cytoskeleton Biology, Center for molecular medicine (CMMC), University of Cologne
2013-2018: Lecturing duties, Institute of Biochemistry I, Medical Faculty, University of Cologne
2013-2018: In-charge: Light microscopy facility of CMMC
2006-2012: Post-doctoral fellow, Harvard Medical School, Harvard University, USA
2001-2004: Ph.D. student, Technical University of Berlin, Germany (Advisor: Prof. Lorenz Adrian)
1998-2000: M. S (by research) Indian Institute of Technology, Chennai, India* (*Founded by Germany in 1958)
1994-1998: Bachelor in Pharmacy, Madras Medical College Chennai, India

Awards, distinctions and professional activities

2015: HFSP young investigator award (30th rank from 1022 applications)
2015: Short listed as one of the top 3 candidates for W2 / W3 professor positions (Universities of Dusseldorf, Cologne, Mainz and Stuttgart)
2008-2009: Post-Doctoral grant by Milton Foundation
2008: First Prize for best work, EMBO Conference on Centrosomes and Spindle Pole Bodies, Heidelberg, Germany
2001-2004: Awarded DAAD Scholarship for pursuing Ph.D. in Germany
1999-2001: Awarded Junior Research Fellowship at IIT-Madras by Ministry of Human Resource Development, Government of India
1999-2001: Awarded Teaching Assistantship at IIT-Madras, India
1998: Qualified GATE (Graduate Aptitude Test of Engineering, an entrance examination conducted at the national level, for selecting students eligible for pursuing Masters at the Indian Institute of Technology)

 

Selected publications

Anand Ramani et al., Gopalakrishnan J*. Plk1/Polo phosphorylates Sas-4 at the onset of mitosis for an efficient recruitment of pericentriolar material to centrosomes. Cell Reports(in press)

Arul Mariappan et al., Gopalakrishnan J*. Inhibition of CPAP-Tubulin interaction preventsthe proliferation of centrosome amplified cancer cells. EMBO Journal (in press)

Goranci-Buzhala G, Gabriel E, Mariappan A, Gopalakrishnan J* Losers of Primary Cilia Gain the Benefit of survival. Cancer Discovery 12, 1374-1375 (2017).

Gabriel E, Gopalakrishnan J* Generation of iPSC-derived human brain organoids to model early neurodevelopmental disorders. J Vis Exp. 14;(122) (2017).

Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J*. Recent Zika virus isolates induce premature differentiation of neural progenitors in human brain organoids. Cell Stem Cell 20, 1-10 (2017).

Li Ming Gooi and Gopalakrishnan J* Regulation of stem cells in their niche. Current Stem Cell Reports, 3, 3, 282-289 (2016).

Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J*, Li H*. Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length. Nat Commun 7, 11874 (2016).

Gabriel E, Wason A, Ramani A, Gooi LM, Keller P, Pozniakovsky A, Poser I, Noack F, Telugu NS, Calegari F, Šaric T, Hescheler J, Hyman AA, Gottardo M, Callaini G, Alkuraya FS, Gopalakrishnan J*. CPAP promotes timely cilium disassembly to maintain neural progenitor pool. EMBO Journal. Apr 15;35(8):803-19. (Cover article) (2016).

Wike CL et al., Jay Gopalakrishnan and Tyler JK. Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans. Cell Cycle. 2016 Jun 1:0 (2016).

Brenke et al., and Jay Gopalakrishnan Identification of Small Molecule Frequent Hitters of GST–Glutathione interaction. J Biomol Screen. 6 Apr 4 (2016).

Persefoni Thomopoulou et al., Jay Gopalakrishnan and Hans-Günther Schmalz (2015). New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology. ACS Med. Chem. Lett. ACS Med Chem Lett. Dec 29;7(2):188-91, (2015).

Zheng X, Gooi LM, Wason A, Gabriel E, Mehrjardi NZ, Yang Q, Zhang X, Debec A, Basiri ML, Avidor-Reiss T, Pozniakovsky A, Poser I, Saric T, Hyman AA, Li H*, Gopalakrishnan J* Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. PNAS, Volume 111, Number 3. (2014).

Pannu V, Rida PC, Celik B, Turaga RC, Ogden A, Cantuaria G, Jay Gopalakrishnan, Aneja R. Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells. Cell Death Dis. Nov 20;5:e1538. doi: 10.1038/cddis.2014.505 (2014).

Anand Ramani, Li Ming Gooi and Gopalakrishnan J*. Building the meat of pericentriolar material surrounding the skeleton of a centriole. Cell News 2/2015, German Society for Cell Biology (DGZ) (2015).

Avidor-Reiss T, and Jay Gopalakrishnan. Cell Cycle Regulation of the Centrosome and Cilium. Drug Discov Today Dis Mech. Dec 1;10(3-4):e119-e124 (2013).

Avidor-Reiss T, and Gopalakrishnan J Building a centriole. Curr Opin Cell Biol; S0955-0674(12)00180-9. (2013).

Schorpp K, Rothenaigner I, Salmina E, Reinshagen J, Low T, Brenke JK, Jay Gopalakrishnan, Tetko IV, Gul S, Hadian K. Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens. J Biomol Screen. Dec 26, (2013).

Gopalakrishnan J, Chim YC, Ha A, Basiri ML, Lerit DA, Rusan NM, and Avidor-Reiss T (2012). Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. Nat Cell Biol 14, 865-873.

Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, and Avidor-Reiss T (2011). Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun 2, 359.

Gopalakrishnan J, Guichard P, Smith AH, Schwarz H, Agard DA, Marco S, and Avidor-Reiss T (2010). Self-assembling SAS-6 Multimer Is a Core Centriole Building Block. Journal of Biological Chemistry 285, 8759-8770.

Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, and Avidor-Reiss T (2008). Drosophila asterless and Vertebrate Cep152 Are Orthologs Essential for Centriole Duplication. Genetics 180, 2081-2094.

Gopalakrishnan J, Görisch H, Adrian L. Studies on hydrogenase activity and chlorobenzene respiration in Dehalococcoides sp. strain CBDB1. Arch Microbiol. 2004 Dec;182(6):498-504.

Gopalakrishnan J, Görisch H, Adrian L. Dehalorespiration with hexachlorobenzene and pentachlorobenzene by Dehalococcoides sp. strain CBDB1. Arch Microbiol. 2003 Dec;180(6):411-6.