Center for Molecular Medicine Cologne

Mario Fabri - assoc. RG

Glucocorticoid regulation of cutaneous Th17 host responses

Abstract

Although Th17 cells are critical to host protection at epithelial barriers, such as the skin, they also play a pathogenic role in inflammatory and autoimmune diseases. Glucocorticoids (GC) are frequently used to suppress undesired inflammation in such conditions. Interestingly, Th17 persistence under GC therapy is not uncommon, which is often explained by a GC-refractory character of these cells. Several studies reported however increased serum levels of IL-17 and circulating Th17 cells in GC-treated compared to GC-untreated patients, which cannot be explained by GC insensitivity, but rather implies a stimulatory effect of GCs on Th17 responses. In this project, we are investigating whether GC are able to induce human Th17 cells and the potential mechanisms involved.

Clinical/medical relevance and sustainability in disease understanding

GC are extensively used to treat allergies, auto-immunity and auto-inflammation, in which Th17 cells play an important pathogenic role. Moreover, long term use of GC compromises host defense at barrier sites and thereby increase the risk for infections. Knowledge of the molecular mechanisms underlying the GC regulation of Th17 cells is important for advancing immunosuppressive therapies to balance inhibition of T-cell-driven inflammation and preservation of Th17-mediated host defense in inflammatory diseases.

Batinica M, Stephan A, Steiger J, Tantcheva-Poor I,Eming SA, and Fabri M (2017). Stimulus-dependent NETosis by neutrophils from a Papillon-Lefevre Syndrome patient. J Eur Acad Dermatol Venereol 31, e239-e41.

 

Former Funding Period 01/2017 - 12/2019

Information from this funding period will not be updated anymore. New research related information is available here.

Prof. Dr. Mario Fabri CMMC Cologne
Prof. Dr. Mario Fabri

Dept. of Dermatology / RG location - LFI Building

CMMC - assoc. Research Group

 

+49 221 478 82269

+49 221 478 5949

Dept. of Dermatology / RG location - LFI Building

Kerpener Str. 62

50931 Cologne

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Curriculum Vitae (CV)

Publications on PubMed

Publications - Mario Fabri

Link to PubMed